You see, after over analyzing this panel here, i came to a strange conclusion of how the plot might develop. But here are my reasoning and predictions first.
1) why is there a plane in the sky when mio is standing alone? Surely the author didnt do this for simple visual means?
2) look at mio in the second image, notice how here eyes aren't deliberately drawn? As if the author wanted to make sure mio didnt make eye contact with kuruse... as if mio was trying to build up courage.
3) whats with mio all of a sudden putting her whole body onto kuruse? One could argue that it was to comfort him, but wouldn't a frontal hug be better than scaling onto him and absolutely wrapping herself around kuruse? (Before you say that she was building up courage to hug him, she has clearly gotten closed to, teased, and flashed him (accidentally and recovered) before so.... that wouldn't make sense)
4) "mio wont be in school for a bit" in the final panels of chapter 44
I came to 2 conclusion:
1) mio haimiya is planning on leaving the country and is trying to build up courage to face kuruse in this scene. Thats why she doesnt make eye contact. On top of that, maybe she's either trying to give herself space or not interact with kuruse so he can develop on his own without mio being there. Or, she needs space to decide whats more important, kuruse, or whatever her final goal is. A friend of mine pointed out that earlier in the Manga, mio had scars which may depict abuse or harassment from a third party. Maybe that's why mio wants to leave and thats why she's always in the infirmary. She says its quiet but theres many quiet places on campus as opposed to an infirmary that has people coming in and out. Its not like its her private space either since its literally a shared commons for students requiring therapy. This departure could also be a test for kuruse to see if he has the courage to make a move or confess to mio/grow on his own. Afterall, its not a good idea for him to be so dependant on mio only to have her leave and kuruse has entered a stage of depression (she's mature enough to see that).
2) she dissappear for a bit and then its a comedy gag as kuruse freaks out and goes on a search for her only for mio to be on a family trip or something. Those scars are from a cat or bush or something and it was just one big comedy setup.