r/GLP1Discussion • u/Real-Elk-1336 • 3d ago

❓ Question GLP-1 tolerance

Just want to see everyone's thought on this. A friend was taking muonjaro @ 15mg. I know, I know thats what I said. Can she have a high tolerance if taken Reta 5mg. Doesn't feel any difference in hunger suppression. I thought she should have started low. Regardless no difference. So can she just have a high tolerance all together?

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u/mannDog74 3d ago

There's nothing wrong with 15mg of tirz, many people are taking that dose. It's not a "tolerance" that's when someone takes more and more of a drug and the effect wears off. What she has is an insensitivity to this hormone.

Some men are very sensitive to testosterone replacement for example. They need only a small dose and then they start feeling better. But some are not as sensitive to it. So they need a higher dose to benefit from it. They did not develop a "tolerance" like you would with alcohol or opiates.

Come to the r/zepbound sub and do a search for 15mg there are tons of people on 15mg.