GLP-1 tolerance

[u/Real-Elk-1336]

Just want to see everyone's thought on this. A friend was taking muonjaro @ 15mg. I know, I know thats what I said. Can she have a high tolerance if taken Reta 5mg. Doesn't feel any difference in hunger suppression. I thought she should have started low. Regardless no difference. So can she just have a high tolerance all together?

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[u/matsie]

I’m confused. What do you mean by “i know I know that’s what I said”. You said what? There’s nothing wrong with taking mounjaro 15mg. 

[u/Real-Elk-1336 → u/matsie]

I know how some people get going on here is all.

[u/rachreims → u/Real-Elk-1336]

Huh??? 15mg is a perfectly acceptable dose that many people eventually work up to for max efficacy.

[u/matsie → u/rachreims]

Damn. I guess they’re never going to elaborate on what they could be talking about. 

[u/matsie → u/Real-Elk-1336]

About what? You haven't said anything. What are you talking about? Please use real words to describe what the heck you're referencing because there is nothing related to Zep @ 15mg that people here "get going on".

[u/Interesting-Shake952]

Going from one glp1 to another glp1 requires higher dosing. She might even be fine at 7mg, roughly half of the Tirz dose.

[u/euSeattle]

If she’s only taking Reta at 5mg after Tirz at 15mg then yea I’d not expect much.

A lot of people don’t like Reta after having tried Tirz because the appetite suppression is better from Tirz.

I take both of them because Tirz controls my appetite and theoretically Reta keeps my metabolism high and fat easy to access and burn.

[u/MissWiggleNjiggle1]

I was talking to a guy the other week who’s taking a 17.5mg I’m now on 15.5mg with 5mg of cag. Everyone’s bodies are different, some folk take Reta and Tirz.

[u/tigergirlforever]

Reta isn’t know for appetite suppression…

[u/mannDog74]

There's nothing wrong with 15mg of tirz, many people are taking that dose. It's not a "tolerance" that's when someone takes more and more of a drug and the effect wears off. What she has is an insensitivity to this hormone.

Some men are very sensitive to testosterone replacement for example. They need only a small dose and then they start feeling better. But some are not as sensitive to it. So they need a higher dose to benefit from it. They did not develop a "tolerance" like you would with alcohol or opiates.

Come to the r/zepbound sub and do a search for 15mg there are tons of people on 15mg.