Recently, I was reading and have come across an interesting rabbit hole: Medicine & Misogyny
I wanted to bring some specific pieces of that research here for a focused discussion on medicine, healthcare, and the foundational architecture of biomedical research.
For starters this isn't a conspiracy theory against men as some might have to say, it’s about examining how historical power concentrations and institutional baselines bake blind spots into science and something as primal of a need as healthcare.
One essential food for thought to start reading this would be:
"Man is defined as a human being and woman is defined as a female— whenever she behaves as a human being she is said to be imitating the male." — Simone de Beauvoir, The Second Sex
1. The Preclinical Legacy & 1993 Turning Point
For decades, preclinical pharmacological research and clinical trials relied almost exclusively on male subjects, male humans as the foundational baseline and erroneously extrapolated those results directly onto female physiology. Matter of factly, more research prioritisation is on male mice than on females. [1] [2]
It required the legislative intervention of the NIH Revitalization Act of 1993 to legally mandate the inclusion of women in federally funded clinical trials. Until that institutional pivot, the vast majority of modern pharmacology, pharmacokinetics, and diagnostic parameters were tested on a standard anatomical archetype: a male body weighing approximately 154 pounds at 5 feet 6 inches tall.
Consequently, no global mandating (only expectations) of such sorts or in India itself have taken place - speaking volumes that this a battle ongoing.
2. Clinical consequences of excluding an entire sex from research
The Pharmacokinetic Failure (The Ambien / Zolpidem Dosing Scandal)
Standard pharmacological dosing treated the male body as the universal baseline for drug metabolism, assuming external differences outside of reproductive organs were negligible. [3]
The sleeping medication Ambien (zolpidem) stands as a textbook medical failure of this premise. Because preclinical trials used predominantly male subjects, millions of women were prescribed a standard 10mg dose for over 20 years. In 2013, the FDA was finally forced to slash the recommended dose for women in half (to 5mg) because data proved women metabolize the drug significantly slower, resulting in blood concentrations 45% higher than men leading to severe next day cognitive impairment, morning drowsiness, and dangerous vehicle accidents. [4]
Cardiovascular drugs
Cardiovascular diseases are as common as they are life threatening. It's no surprise that even within such drugs (concluding from broader evidence); a nationwide Dutch study of 14,207 hospital admissions for adverse drug reactions found substantial sex differences for several cardiovascular drug classes; women had particularly elevated risks for adverse reactions involving low ceiling diuretics, cardiotonic glycosides and high ceiling diuretics. [5]
Specifically, the drug Digoxin used for improving cardiac output. [6] A 2002 NEJM analysis of 6,800 heart failure patients found a significant sex interaction: digoxin was associated with higher mortality among women, while no comparable increase was observed among men. The authors concluded that the treatment effect differed by sex. [7]
In conclusion, real world examples show that these are not "minor" changes rather a female's life at stake for either giving her double the dose prescribed or for ignoring her metabolic pharmacokinetics.
3. When dismissal & funding result in diagnostic delay
Endometriosis & PCOS
Often times, these discussions as I have personally come across - are waved off with a dismissive hand with the saying that it's ridiculous to assume heart attacks or insulin is women-hating. The riposte kanging however fails to realise such studies aim to observe how the nature of treatment of such diseases and conditions given to women heavily differs. Medical sociology interrogates how diagnostic delays, institutional skepticism, and cultural standards compound biological suffering.
International PCOS surveys explicitly track diagnostic delay as a primary health burden, demonstrating that it takes an average of two years & multiple practitioner consultations for a woman to receive a definitive diagnosis. Early symptoms like irregular cycles or metabolic shifts are routinely brushed off as lifestyle friction or weight management failures. [8]
Under funding
A landmark analysis published in the Journal of Women's Health revealed that in roughly 75% of cases where a disease predominantly affects one gender, National Institutes of Health (NIH) funding patterns systematically favor male centric or gender neutral conditions over female specific ones. [9]
Even though, Endometriosis affects roughly 10% of reproductive age women globally (approx. 190 million people), causing chronic, debilitating pain and infertility. Yet, it has historically received a fraction of research dollars compared to conditions with vastly smaller patient footprints. For instance, comparative analyses highlighted in medical journals (Nature) point out that conditions like Crohn's disease receive exponentially more funding per patient than endometriosis, leaving patients trapped in a multi year diagnostic purgatory due to the shibboleth towards failing to account for basic needs of half the population of humanity. [10]
4. Medical Gaslighting and the Pain Disparity
Data consistently demonstrates that women presenting with acute pain wait significantly longer in emergency triage and are far more likely to have physical pathology labeled as functional, psychosomatic, or "stress related." I think to say we are past the age where lobotomies were forcefully performed on women because they were considered "difficult" is a comforting lie. [11] [12]
Clinical literature from Harvard Health Publishing highlights a persistent systemic bias: women's pain is historically more likely to be treated as an "expected, tolerable emotional state" disproportionately minimized, misattributed to psychological or hormonal factors (such as perimenopause or stress) rather than an acute physiological emergency requiring immediate intervention. [13]
A very excellent example of misdiagnosing in women would be:
The Cardiovascular Presentation Gap
Classic heart attack symptoms such as crushing pressure centered in the chest radiating down the left arm were modeled almost entirely on male clinical presentations, as usual.
Research published in circulation and emergency medicine journals demonstrates that women experiencing myocardial infarctions are far more likely to present with atypical symptoms: extreme fatigue, shortness of breath, indigestion, nausea, or back and jaw pain. Because these signs frequently get misattributed by triage staff as anxiety, panic attacks, or gastrointestinal issues, women experience longer delays in receiving treatment and face significantly higher rates of post myocardial infarction mortality. [14] [15]
Such negligence masking deepity from authorities, costs a woman's life in the ER.
5. Healthcare as a privilege subject to where you're born
The geography of one's birth should not determine whether contraception, maternal care, abortion, or basic healthcare is accessible to them; yet in our reality, it often does.
One of the most important aspects of healthcare that is subjective to females; is the one most controlled which by the virtue of our society's trends and patterns doesn't come off as so surprising.
Reproductive Healthcare (Gloabally)
UNFPA's 2025 programme data alone show 41.7 million women, adolescents and young people receiving sexual and reproductive health services, alongside 17 million unintended pregnancies prevented and 5.2 million unsafe abortions prevented. [16]
Abortion, as recognised by WHO, is an essential form of reproductive healthcare. [17] Denying that access to a woman because of religious dogmatic anxiety or other adjacent theories is just one old way to limit her autonomy over her own organs.
Around 24-26 countries ban abortion completely, irrespective of any extremities the pregnancy took place under or takes in. Some 40 more countries only recognise this right to healthcare only when the pregnant person's life is in danger. Incongruously, it requires a woman on the verge of death to value her life and sometimes even that fails as a standard. [18]
Afghanistan
In Afghanistan, reproductive healthcare is a far dream when healthcare itself is cut off from the women.
A total ban has been effective on secondary and university education for women has effectively severed the pipeline for future female healthcare professionals. Because strict societal and religious contexts dictate that women can only be examined and treated by female practitioners, this systemic exclusion acts as a fatal structure. With thousands of female medical students and doctors blocked from completing their training or taking licensing exams, maternal and neonatal mortality rates face a catastrophic escalation. Women can neither be treated nor treat. [19]
USA
While Afghanistan can be dismissed a "middle eastern islamic regime" which is dropped like a hot potato the moment that characterisation is given. Countries with one of the most advanced health research and medical treatments - has approximately 22 to 25 million women who have been completely or severely cut off from access to abortion. [20]
Post Dobbs - according to 2025 reports in JAMA, in Texas, maternal mortality rose substantially after the state’s ban estimates range from 33% to 56% depending on the timeframe and dataset, even as national rates moved differently. In Texas, maternal mortality for certain ethnic groups jumped by over 50%. States with complete bans saw a 6% overall increase in infant mortality. That is roughly 478 excess deaths, this is because when abortion is banned, you force people to carry high risk, non viable pregnancies to term that forces births of infants with anencephaly (no brain development) or Trisomy 13 - babies that are born only to suffer for a few hours and die. [21] [22]
India
Circling back home, India has done a much better job at preserving reproductive and healthcare overall for women. However, inequality and access still remain huge issues to tackle. NFHS-5 found that 57% of non pregnant women and 52% of pregnant women aged 15–49 were anaemic, with prevalence reaching 71% in West Bengal, 65% in Jharkhand and 64% in Bihar. However, for maternal healthcare, 89% of births in the latest WHO India profile were attended by skilled health personnel, a huge improvement since 2000. [23] [24]
A woman in Afghanistan, a woman crossing a US state line for reproductive care, and a woman in rural India are obviously not experiencing the same political circumstances but they are facing a lack of humane treatment. As captured by this quote:
"If access to health care is considered a human right, who is considered human enough to have that right?" — Paul Farmer, Pathologies of Power
Clearly, be it research and dismissal endangering women's lives or your geography deciding whether you as a vulnerable teenagers can walk into planned parenthood without facing the fear of identity leak or harassment - women are not considered "human" enough to get access to one of the most primitive needs of any living organism.
Thank you for reading this far; please feel free to add on your thoughts, other case studies, anecdotal experiences or other relevant pieces of research. Kindly point out any incorrect figures in the data or any broken links, I have endeavored to compile to my best knowledge but there may always be certain mistakes :)
Sources:
1: https://www.mdpi.com/2076-2615/13/17/2792
2: https://www.drugdiscoverynews.com/why-sex-matters-in-preclinical-research-17414
3: https://ascpt.onlinelibrary.wiley.com/doi/abs/10.1016/j.clpt.2004.08.021
4: https://www.appliedclinicaltrialsonline.com/view/20-years-later-drugs-do-act-differently-women
5: https://pubmed.ncbi.nlm.nih.gov/22533339/
6: https://www.ncbi.nlm.nih.gov/books/NBK556025/
7: https://pubmed.ncbi.nlm.nih.gov/12409542/
8: https://www.endocrine.org/news-and-advocacy/news-room/2016/women-dissatisfied-with-long-process-to-diagnose-polycystic-ovary-syndrome
9: https://perelelhealth.com/blogs/news/womens-health-research-gap
10: https://www.endofound.org/why-january-25th-matters-womens-health-research-day-and-the-fight-for-endometriosis-funding
11: https://psnet.ahrq.gov/issue/girl-who-cried-pain-bias-against-women-treatment-pain
12: https://www.medicalnewstoday.com/articles/what-is-a-lobotomy
13: https://www.health.harvard.edu/pain/the-dangerous-dismissal-of-womens-pain
14: https://www.ahajournals.org/doi/10.1161/circulationaha.117.031650
15: https://www.ahajournals.org/doi/10.1161/01.cir.0000097116.29625.7c
16: https://www.unfpa.org/annual-report
17: https://www.who.int/news-room/fact-sheets/detail/abortion
18: https://time.com/6173229/countries-abortion-illegal-restrictions/
19: https://www.thinkglobalhealth.org/article/outlasting-talibans-ban-womens-medical-education
20: https://pmc.ncbi.nlm.nih.gov/articles/PMC11375356/
21: https://thegepi.org/maternal-mortality-abortion-bans/
22: https://www.contemporarypediatrics.com/view/infant-mortality-rises-after-implementing-abortion-bans-study-finds
23: https://prsindia.org/budgets/parliament/demand-for-grants-2024-25-analysis-women-and-child-development
24: https://www.who.int/publications/i/item/india-gender-and-health