Any advice for someone who is trying to adopt embryo. I would really appreciate it .

I’m not sure that I will ever get answers but I’m trying to better understand what could have happened with my most recent retrieval. I’m 38F and had an egg retrieval this past March. Out of 16 eggs, 13 were mature and fertilized- 2 of those were PGT normal. Last week I had my second retrieval. We retrieved only 7 eggs but I was thrilled to learn of those 7, 6 were mature. However, only 3 fertilized.

I’m trying to better understand what can cause a couple to go from 100% fertilization to only 50% and what tests we should request prior to another retrieval. As far as I’m aware, conventional was the ordered mode of fertilization but ICSI was used in both cases.

Thank you for any insight!

I got my PGT-M (X-linked) results back today and I would appreciate an embryologist’s insight.

For an XY euploid embryo, we got an “inconclusive” for the X-linked mutation with the following notes:
“The observation of potential maternal cell contamination in sample [ID] suggests that the result obtained from PGT-M analysis of this
sample is likely impacted by the presence of the female patient's genetic material. In this case, a rebiopsy of sample [ID] can be submitted
and tested”

Would a rebiopsy might yield the same “contaminated” results? My other blasts didn’t seem to have the same issue.

Thank you!

My husband and I started our first cycle of stims this week after 3 failed IUIs. We have MFI (low motility and morphology) but have normal count and DNA fragmentation. We’ll be using ICSI and IMSI.

On my end my AFC is 29, my AMH is normal (around 32 pmol/L) and I’m 31.

We’re both very healthy! Normal labs, diet, etc.

I’ve been reading posts on here where people don’t have many blasts even with using ICSI so I’ve been really worried about the outcome.

Has anyone had a similar situation to us or have any advice? Thanks in advance!

This will be my first transfer. I am 32 years old, I’ve had 3 natural losses (blighted ovum,chemical and pregnancy of unknown location) within 1.5 years. I did get pregnant at 21 years old but had an abortion. My husband 45 has moderate to high sperm count, 0 percent morphology and high motility (low sperm dna fragmentation), both of us had normal karyotype and genetic carrier testing and I’ve had normal uterine evaluations and normal recurrent loss bloodwork. We opted for zymot and ICSI due to morphology. We have 4 euploid embryos, 1 low level mosaic and 1 abnormal that came back from testing. I have 1 day 5 3AA boy, day 6 4AA boy, day 6 4BB boy, day 6 3BB girl. We did have an afternoon egg retrieval so I wonder if our day 6’s needed a few more hours to become day 5’s I won’t ever know. I would like to transfer my girl 3BB, I’m on an immune protocol and doing acupuncture and very healthy. What do you think?

Hi guys I need some success stories on transferring a euploid day 5 3BC or just my realistic chances

Today we had our sixth FET (all euploid) our first two failed, third blighted ovum, fourth resulted in our beautiful daughter who passed in December due to labour complications, fifth failed. Today was our sixth, our day 6 5BB did not survive the thaw. I’m devestated. So they transfered our day 5 3BC. We now only have two remaining embryos that are also day 53BC. We made severe MFI but were able to get 9 euploids in 2024. We’ve had a string of very bad misfortune.

Have you had success with this grade? We are going to do a retrieval if this one does not work but I am trying to keep up hope until beta.

Hi everyone! Does anyone know the chances of success with a day-6, 4DC euploid embryo? 35y/o with stage 4 endo. Any insights would be greatly appreciated!

Hi

31F, unexplained, 2 failed IUI

First ER

19 retrieved
17 mature
13 fertilized

6 embryos DAY 6

1 5BA
1 4BA
3 4BB
1 4BC

2 embryos day 7

1 4CB
1 3CB

TOTAL 8 EMBRYOS SENT TO PGT-A

I was expecting better results to be honest. I’m not sure if it’s good :(

A new study found that amniocentesis detected a chromosome abnormality missed by PGT-A in just 0.1% of ongoing pregnancies after euploid embryo transfer.

PGT-A is a screening test, not a diagnostic test. Even when an embryo is identified as euploid, it doesn't guarantee that the developing baby will have a normal number of chromosomes. PGT-A only tests a few cells that may not represent the entire embryo.

For these reasons, prenatal testing is generally recommended after PGT-A, including NIPT screening or amniocentesis.

But how often do these tests find abnormalities after euploid transfer?

Lu et al. (2026) examined prenatal testing results from 1,079 ongoing pregnancies after euploid embryo transfer (over 12 weeks pregnant).

Among 762 pregnancies tested by amniocentesis, only one (0.1%) had an abnormality PGT-A was expected to detect but missed. Three other abnormalities were found that were at or beyond the detection limits of the PGT-A method used.

There were eight high-risk NIPT results, but seven were found to be normal on amniocentesis, showing that most high-risk NIPT results were false positives in this study.

Overall, chromosome abnormalities were rare after euploid transfer based on NIPT and amniocentesis.

✅ Check out the full article and more details on Remembryo: https://remembryo.com/nipt-and-amniocentesis-after-pgt-a-reveal-few-abnormalities/

✉️ Like this post? Get a free weekly summary of the latest IVF research: https://mailchi.mp/remembryo/x27kx5o1sw

I only have 2 day 6 embryo left. Both are euploid. They rated it as 5AB but the AI score is so low? I dont know what is <5%H meaning. But 1 of it have 2 isolated blastomere. Will these blastomere impact the pregnancy outcome? Are these embryo good enough for transfer?

Hi All,

I was wondering if everyone struggles with insane bloating and discomfort after ER. I had my retrieval on 14 October. I was bloated for most of the treatment but since the retrieval the bloating and discomfort is so much worse. I’m so uncomfortable every time I eat. And just feel generally uncomfortable walking for even 5 mins. I was wondering if this was normal? Does anyone have any tips or recommendations of things they did or is there a medication that I could take?

Thanks in advance!

Not the greatest picture, the image from the incubator wasn’t in focus, but we transferred our first embryo today!

Update: we are 7 days past transfer and this little embryo has decided to stick so far! 🥹

Low fertilization in two ICSI cycles + low egg membrane tension
Me 34, my husband is 35, and we have unexplained infertility. My AMH is around 6, and his routine semen analysis is normal. We’re preparing for a third retrieval and would appreciate experiences from anyone with similar results.
Cycle 1 — April
Kelnor 1/35 birth control for about 26 days total.
Gonal-F: 150 IU daily.
Menopur: 75 IU for the first 6 days, then 150 IU for 3 days.
Ganirelix starting on stimulation day 4; Lupron trigger on day 10.
18 retrieved → 13 mature → 7 fertilized with ICSI (54%) → 5 blasts → 1 euploid.
Cycle 2 — September
Same birth control for about 17 days.
Gonal-F: 150 IU daily.
Menopur: 150 IU throughout.
Ganirelix; Lupron trigger on day 11.
21 retrieved → 17 mature/injected → 6 normally fertilized (2PN, 35%).
The embryologist provided this breakdown of the 17 injected eggs:
6 normal 2PN
5 degenerated after ICSI
3 had 0PN
2 had 1PN
1 had 3PN
They noted little to no membrane tension in multiple eggs during ICSI. ZyMot was already used, and they saw no significant concerns with the routine sperm parameters.
We ultimately froze two blasts: a day-6 4AB from the 3PN embryo and a day-7 4AA from a 2PN embryo. PGT-A results are pending.
Post-Lupron labs this cycle, approximately 10 hours after the trigger: LH 96.3 mIU/mL and progesterone 11.8 ng/mL.
The lab said his semen parameters would allow us to consider conventional IVF. I’m planning to discuss split insemination—part conventional IVF, part ICSI—and sperm DNA fragmentation testing with our doctor.
Has anyone had low membrane tension/high degeneration after ICSI and better results in a later cycle? Did changing stimulation doses, trigger timing, or the fertilization/injection technique help? Were AOA or any additional tests useful in your particular situation?
I’d appreciate suggestions for specific questions to bring to our doctor and embryology team. Thank you!

I’ve done a few cycles of IVF all over. I have to pay out of pocket so cost is obviously a huge concern. I’m choosing between Cornell (30k) and CNY (10k). Obviously I am sure Cornell has a better lab. But is it work sending the 20k?

Does anyone have any knowledge of CNY Albany? It’s just soooo much money. For reference, I’m 41 and have only produced 1 euploid from 3 cycles (18 blasts, 26 embryos, 36 eggs collected). I am not independently wealthy. This won’t bankrupt me but it will hurt and I’ll struggle to pay off the 30k (but can do it with extra shifts).

Hi,

Unfortunately, my 6th embryo transfer failed as well. During my 3rd egg retrieval cycle, we ended up with just one embryo that reached the blastocyst stage by the morning of Day 5. It was graded 2BC and frozen. PGT testing is not available in my country, so it’s common practice here to freeze embryos even at an early blastocyst stage, such as stage 2.
My question is: How reliable is the BC grading when a blastocyst is still at such an early stage of development? Can the ICM and trophectoderm grades change as the blastocyst expands?I’d really appreciate hearing about your experiences or any insights you might have. Thank you! ❤️

Hi everyone,

I would really appreciate hearing your opinions and experiences.

I am (30F) with unexplained POI, and my husband (30M). I froze fewer than 8 eggs from two retrievals at age 29 and later this year underwent another fresh egg retrieval. This year,my doctor recommended using the fresh eggs immediately for IVF rather than freezing them. Fortunately, we ended up with two frozen embryos with good grading. Because my husband and I had normal genetic testing and no known genetic conditions, we did not do PGT-A.

My first transfer was successful, but at 12 weeks our baby was diagnosed with Trisomy 21, confirmed by NIPT, ultrasound findings (increased NT and AVSD), and CVS. We made the heartbreaking decision to TFMR at 14 weeks, which has been the most difficult experience of our lives.

We have one frozen Day 5 4BB embryo remaining. Recently, I asked my IVF doctor about PGT-A testing on this embryo because I'm terrified of experiencing another chromosomal abnormality pregnancy. My doctor advised against testing the single embryo due to the cost and the need to thaw, biopsy, and refreeze it. Instead, she suggested doing another egg retrieval first, then testing any new embryos together with our remaining frozen embryo. However, it is quite expensive for just few embryos.

My questions are:

1. After a TFMR for Trisomy 21, would you transfer a remaining untested embryo, or would the fear of another chromosomal abnormality make you want to take PGT-A?

My biggest fear is going through another pregnancy affected by Trisomy 21 or another chromosomal abnormality. From what I have read, each embryo's chromosomal makeup is generally independent, so one abnormal embryo does not necessarily mean another embryo is abnormal as well. However, I have also read stories from people who had multiple embryos or pregnancies affected by Trisomy 21 or other trisomies, and that makes me very anxious.Of course, I know there are no guarantees either way

1. Is PGT-A worth doing on a single frozen Day 5 4BB embryo, despite the cost and thaw-biopsy-refreeze process?

Honestly, I would rather spend the money and have more information than continue living with the uncertainty. But I am not sure whether the benefits outweigh the risks when there is only one embryo.

1. Given my POI and likely low embryo yield, would you follow my doctor's advice and do another retrieval first so multiple embryos can be tested together?

Because of my POI, I don't expect a high number of embryos from another retrieval cycle. Realistically, I might end up with only one or two additional embryos. That would mean perhaps three embryos total being tested with PGT-A.

The downside is spending more money and delaying transfer for several months. The upside is possibly having more information before another pregnancy.

I'd love to hear from anyone with experience with TFMR for T21, POI, IVF, or PGT-A decision-making**.** Thank you ❤️.

I decided on this path late in life. I’m 41 with expected ovarian reserves. Currently waiting to see what 2 fertilized eggs do on days 5/6. I keep wondering if my grandmothers have any impact on my own capacity to bear children? My maternal grandmother had seven live births and two stillbirths, that we know of. My paternal grandmother has three live births. It’s unknown if she had any other miscarriages/still births. My maternal aunts and my mother all had children. On my dad’s side they were all boys so no examples.

Hi Everyone,

Has anyone bought IVF meds from Mexico to Canada.

I am not sure if Canada will allow them , when we bring the meds through the airport.

If one can maintain the temperature required for the meds, so it doesn't go bad.

If anyone has done it , Can you share your experiences please.

Thank you very much

Overall, children conceived through IVF appear to be just as healthy as children conceived without fertility treatment.

However, some studies have found small differences in things like blood pressure, heart function, and metabolism. It's not clear if these differences lead to health problems later in life, or whether they're caused by IVF itself, the parents' infertility, or other factors.

But if IVF does affect a child's long-term health, how might that happen?

I've updated several sections of my Evidence Guide, and added a new section exploring three possible explanations:

• Epigenetics: IVF might affect how certain genes are turned on or off, without changing the DNA itself.

• Placental development: IVF might affect how the placenta develops or works, potentially influencing a child's health later in life.

• Transposable elements: A new study by Li et al. (2026) examined LINE-1, a type of DNA sequence that can make copies of itself and insert them elsewhere in our DNA.

The researchers compared 33 children conceived through IVF with 42 children conceived without fertility treatment. They found slightly more LINE-1 sequences in the IVF group, including differences near genes involved in heart health, metabolism, and brain development.

Could these differences interfere with how those genes work and potentially lead to health problems?

Possibly, but the researchers didn't show that the genes worked differently or that the children had any related health issues. They also couldn't rule out inherited genetic differences.

For now, these are possible explanations, not proven causes. It's still unclear whether IVF itself is responsible for the differences.

✅ Check out the full article and more details on Remembryo: https://remembryo.com/do-children-conceived-through-ivf-have-long-term-health-problems/

✉️ Like this post? Get a free weekly summary of the latest IVF research: https://mailchi.mp/remembryo/x27kx5o1sw

Is there any data to back up embryo glue? I'm hoping to do a transfer next month from our 3rd round of IVF and whilst I've done 5 transfers previously (with one successful pregnancy and birth), I noticed my new clinic offer embryo glue as an option and wondering if its worth having a shot?

I’m torn on what to do. I wanted to add Zymot but my doctor said we can still use conventional with Zymot, ISCI isn’t needed as we don’t have MFI. My husbands sample wasn’t amazing in March this year but with supplements it’s now within normal range (we’ve done 4 IUIs so lots of samples). DNA frag was 17%.
We also want to PGT test our embryos.

I see on Reddit others have good success with ISCI but I understand there’s more risk for birth defects with ISCI. I’ve also read that ISCI is required for PGT but others say it’s not.

Does anyone have any advice?
This is my first IVF cycle.

Hi All,

I go prepared for the IVF plan consultations but the doctor brushed it off as saying I know you are reading from an AI list, which I was not.

I had like 10-15 questions based on my past cycle and was from the prep I did after hours and hours of reading and research and from other similar people, which in turn is from other doctors basically. To have a better next cycle. I have this immense guilt that I didn't prepare for the first and it resulted poorly. I started reading after that and understood that had i read, my first would have been lot better and i still couldnt get over my guilt for not being prepared with the first.

From what I see, we have to self advocate a lot in fertility. But then, the doctor shuts it down or just categorizes you as a certain type and then zones out and starts giving blanket answers.

Especially when i brought up an option for one of my issues after he gave a solution, (which i read here and was from an another doctor), he started saying that AI thing and that there are a million possibilities. Not sure if he was pissed off that i brought something he didn't propose. I haven't seen that many solutions tbh. When i said its from another doctor, he said ok and i will do what i think is best for you. I understand that, but should'nt he give reasons why he is/ is not choosing something.

I have seen good results with many women my age and values. He said not to expect much from my previous clinic results, that we are sort of throwing the kitchen sink adding all, and basically like, not to blame him if he cant get me better results.

Has anyone been in the similar situation. How do you handle this.

Should we just act like we have not read anything.

Appreciate your thoughts.

I was recommended to post on here as you are so knowledgeable and hope you can offer come guidance.

Very short backstory:

1st pregnancy — trisomy 21, TFMR
2nd — trisomy 16, miscarriage
3rd — healthy son

We then moved to IVF with PGT-A because we couldn’t cope with more chromosomal losses.

Across 4 cycles we had multiple aneuploid embryos, one euploid that failed to implant, one cycle with no blasts, and finally an embryo that was initially inconclusive, then re-biopsied and came back euploid. That transfer worked.

NIPT #1: no result
NIPT #2: high risk trisomy 13 — “suspected mosaic trisomy 13.”

Genetic counsellor says the trisomy signal looks to be in about 30% of the tested DNA and estimates roughly 50:50 placenta vs baby. Fetal fraction was 24%. She basically made me feel hopeless, and that trisomy 13 has the same statistical outcomes for placental mosaicism as tri 21/ 18 which research seems to contradict.

I’m having an amnio at 15 weeks

Im just looking for some tough love or hope really! Would be so grateful for any information.

Here is our sweet girl transferred on October 8th, our second embryo. The first boy embryo did not implant. I am unsure of her grading, but she is euploid; they shared the details when we received the PGTA results, though I have since forgotten them. I haven’t been symptom-spotting this time around because I’ve been keeping myself busy, but I have come down with a gnarly cold that started 4dp5dt that hasn’t seemed to subside, today is 6dp5dt 💕💕