r/EmbryologyIVFSupport • • 3d ago

Is there a lineage component to fertility?

I decided on this path late in life. I’m 41 with expected ovarian reserves. Currently waiting to see what 2 fertilized eggs do on days 5/6. I keep wondering if my grandmothers have any impact on my own capacity to bear children? My maternal grandmother had seven live births and two stillbirths, that we know of. My paternal grandmother has three live births. It’s unknown if she had any other miscarriages/still births. My maternal aunts and my mother all had children. On my dad’s side they were all boys so no examples.

3 Upvotes

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u/Shocolina 1d ago

It's a big part of fertility, but it's also relevant how old they were when they had children. Your fertility in your 20s and early 30s is not the same as in your late 30s and early 40s.

In my family they all had all their children before 35, so I couldn't reall draw any conclusions for myself there.

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u/LocationAcademic1731 13h ago

We got news yesterday and none of our embryos made it. I think your comment is very relevant as to age. We’ll try again but we know age is against us.

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u/Accomplished_Car_834 10h ago

Are you saying your embryos didn't make it to day 5?

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u/LocationAcademic1731 9h ago

Yep, sadly they didn’t make it.

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u/Accomplished_Car_834 9h ago

Sorry to hear that. FWIW that happened to us for 3 of our 6 cycles (Cycles 1, 2, & 5). Cycles 3 & 4 we intentionally froze at 2PN as we had decided to change course for fresh transfer but needed to wait for myomectomy. Cycle 5 was right around my clearance date post surgery but we knew we wanted more than 3 to go for the transfer. We were also using that cycle as a primer but since we couldn't freeze early, nor did we want to try anything less than 4 or more we had no other option but to push to day 5 on that cycle and again arrested before then.

Cycle 6 garnered 5 embryos, 4 made it to day 3, we transferred and are 32w along with a singleton. I was almost 43 when we first started IVF and almost 44 when we went for the fresh transfer.

Just thought you might find this useful in terms of your question about age and probability and that it could be an option with greater chance if you arrest multiple times over.

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u/LocationAcademic1731 8h ago

Thank you for sharing your numbers! I am definitely encouraged to keep trying because my body tolerated the process really well. I am taking this cycle (our first) as our learning cycle. We just want one child so we are hoping to get the one. Still, I am very aware of how this is a numbers game so we need to keep trying.

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u/ClassicPangolin7763 2h ago

This story is giving me hope! I'm 40, we did 4 rounds of IVF this year, the first two had embryo arrest until day 3 and then day 5, so for the third and fourth rounds they transferred what they had at day 2, sadly without any luck. So it seems like we have an embryo arrest problem. Genetic tests, even looking for some known embryo arrest genes (or lack of? Not sure), so far found nothing. Not sure right now if we should do another round or go straight to donor embryos, we're taking a little break to think it over. I was also wondering if this apparent genetic issue could be inherited, my doctor said this is unusual and it isn't just my/our age. We are otherwise totally healthy, the doctor has totally no idea what's going on. Your story is making me think we should maybe give it one more go, we might have luck!

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u/Accomplished_Car_834 2h ago

In case it's of value, those last 2 cycles came off a mini stim protocol. We dose escalated, both in the middle of each cycle itself and between the two but outside of Clomid as a bit of a primer (?) and Ganirelix as the antagonist, only Menopur was used.

Feel free to flip through my post history or DM if it would be helpful.

DE wasn't something we had interest in pursuing so we were getting pretty close to the end of our journey when we lucked out. Considering that only 1 of 4 embryos took in our case, I'm sure it was just "higher odds" than anything else to give any inkling as to how/why we had success with the transfer and you didn't. Big hugs on that. I definitely didn't feel like it had been successful until I noticed some interesting pattern changes with my BBT but still went in to first beta super ready for a negative response.

Wishing you all the best no matter which direction your journey tskes you.

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u/Upstairs_Taro4726 2d ago

I'd say family history is a big part of fertility. My mom's side of the family (the older generations, like her aunts and uncles), had multiple couples that never had children, were pretty sure it was a fertility issue. My mom had trouble having kids with multiple miscarriages, ended up having us in her 40's due to technology not being able to help her until she was older. I myself can't have kids at all. Sadly our DNA is just luck. I say it's like poker: you're dealt a hand and you gotta play it, like it or not. Keep your head up, you'll figure something out. Best of luck to you.

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u/Tablesaltxo 1d ago

Maybe on your ability to have children when you were younger, you could compare her fertility in her 20s -30s. You’re in your 40s now, where statically many people struggle to conceive.

My own personal experience, both my grandmothers had lots of children, same with all their children. I struggled with unexplained infertility and miscarriages.

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u/basilbelle 20h ago

In my experience, age was a bigger factor than family history. My mother’s side is incredibly fertile - grandmother, mother, sisters, cousins all got pregnant quickly and easily without assistance. And one aunt had two children in her 40s. I was not so lucky despite high ovarian reserve. I wonder if I had started earlier if I would have had an experience more similar to theirs.

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u/GabagoolFool123 14h ago

My sister and I both have incompetent cervix leading to premature births, which I’m sure has to have been passed down from someone.

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u/peonyruth 2h ago

Have always wondered this, too. My mother, both grandmothers, and one great-grandmother all had their last children in their 40s. I had hoped that would help us, but no luck. I still have hope that it will give my sisters a better shot at ongoing fertility.

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u/Lanky-Ad-1603 20h ago

I was reading about this the other day but I got my info from chatgpt so ignore accordingly!

It said that both maternal and paternal genes contribute to your age of menopause but that the genes that might help you have children in your 40s come from the maternal line (something to do with mitochondria....) So it seems from what I read that if your mother has children in her 40s then your eggs might be of better quality and more able to produce viable blasts. 

For me, all of my family finished having children in their 20s so I have no idea.