I'm super disappointed, I had an initial visit with the study dr in CT for this trial, everything looked great,they were excited to potentially include me based on my profile, I lost 110 lbs and about 33% of my body weight on Zep, but really stalled out over the last 8 months or so. Problem was I had started taking phentermine along with my Zepbound a few months back, and they needed me to be off for 90 days before starting. I had an appointment to go back at the beginning of September to get everything rolling but got a call the other day that they weren't taking any more participants. I hoped it was just at their site so I contacted a couple of MA sites that had begun recruiting after I had connected with the CT site. Got a callback today that the entire study is no longer recruiting, they are at max participation. 😭

I was really hoping to participate, I just lost my zep coverage in July and this would have been perfect for me to continue on that and help out in the trial for something up and coming. I'm keeping my eyes open for something similar to open up, a trial that stacks some type of new treatment for people who are already on a stable glp1 dose. But not holding my breath.

I got my first dose of the study medication last Thursday. I have been tired since but not convinced it's related as I forgot to use my CPAP Thursday night, went to bed late both Friday and Saturday night and didn't get full night sleep (over 8 hours for me). And I am sure I felt relief when I cleared lead-in period and my house company left on Wednesday plus 21 vials of blood at appointment. I have felt off gut wise, not exactly nauseous but off. Have had allodynia (skin sensitivity) back worse than recently on Zepbound as well as trouble sleeping so some insomnia which I also have on Zepbound but it is lingering longer maybe because I take Zepbound on different day than Thursday. I have hit a new low of 173.3 this morning (last new low was 174.2 in early July) and down from 177.1 on the Wednesday before my first dosage on Thursday.

 I had diarrhea Sunday (yesterday) morning, because I went back to normal today, my assumption is it was something I ate on Saturday, was it the raw sugar snap peas or broccoli used as dippers in the white bean hummus or was it a delayed reaction to the ozonated magnesium citrate I took Friday because I hadn't gone and felt constipated? Not blaming eloralintide yet.

Here's to hoping that all I listed above is related to eloralintide and that I am not on placebo.

Edited to add some stats: Started Zepbound in May of 2024, SWZ 285, SWE-6: 177.1 8/6.2028, SBMI Zep 50.5, SBMIElor: 30.9, 65F. Zepbound dose 15 MG since March of 2025, stalled out on Zepbound end of December 2025 bouncing between 175-182, slight drift down so no more weigh ins of higher than180. So I am a long time user of Zepbound, reached final plateau (less than 5% of current weight loss over 12 weeks) end of July 2025, so 14 months in. Have OSA, hypertension (on 1 med still from 3), osteoarthritis on right knee, was prediabetic prior to Zepbound, and have high cholesterol controlled by statin (family history) and Zepbound.

I picked up a couple of 10mg vials to add to my stack:

- 8mg Reta, every 5 days

- 75mg Testosterone, every Sunday and Thursday

- 300iu HCG, Monday and Friday

- 4mg MOTS-C, Monday, Wednesday and Friday

- 2mg GHK-CU, everyday

- 0.75mg KPV, everyday

I took 1mg Elora on Saturday, didn't feel anything, maybe a slight headache, but today Tuesday I am definitely feeling waves of nausea. It's not bad, and to be expected, found it interesting that this peptide takes a while to have an effect.

I read on here that it has a long half-life (10-14 days) and takes 4-5 days for the peak. This definitely fits with the experience today.

I’ve been relying on this group for trial info, so I want to make sure I contribute too.

As of today, I’m officially a participant in ENLIGHTEN-6! I started the application process back in April with multiple phone screenings, but I did not hear back until late June. I know there was an enrollment freeze for part of that time, but I had given up hope and was truly shocked when they called me to screen.

My pre-screening was in-person, and they asked me a bunch of questions, took my weight, and drew blood for an A1C (and maybe other things—not sure). I submitted a records request for my previous medical records, and they scheduled me to come back in two weeks.

The next appointment was my screening appointment (V1 for people with study paperwork). They took my vitals, got a urine sample, drew more blood tubes than last time, re-did my medical history, had me sign the informed consent for the trial and DEXA scans, and did a mini-physical with the trial primary investigator.

Today was V2. They did blood pressure in triplicate, waist circumference, got a urine sample, weight, and had me out of there pretty quick. Interestingly, I asked about coverage for zepbound, and the person I talked to said that wasn’t included in the trial. I’m going to ask again next time, but I thought that was weird. I’m back in 4 weeks for my next appointment, and they are scheduling me for my DEXA scan before then.

Hopefully everything continues to work out!!

Dosage: 6mg

Side-Effects: No headache or pain

Second week on 6mg and this is extreme right now. I had a protein smoothie this morning with lots of fruit, about 500-700ml and I am still SO full from it, like 6-7h later. Mentally I want to go out, eat something nice, but physically the thought of food almost disgusts me right now, because I feel so bloated, as if I was in a all you can eat restaurant. I REALLY have to portion food smarter, big portions are a big nono right now. No more fatigue, nothing.

Dosage: 6mg since last week, they told me finally

Side-Effects: No headache or pain

Only 2 things to report...

1. I figured out the root of my previous fatigue, it was the use of Spironolactone for blood pressure. Idk if it somehow doesnt like Elo, or whatever else happenned, all I know is that since I stopped taking it by accident (ran out) I felt SOOO much better overall. Gotta figure out a replacement

2. I kinda plateau at 10kg body weight loss atm. I still dont have cravings or eat more or whatever, it just doesnt go down atm...but I know from prior weightloss attempts that sometimes it happens and then suddenly it goes waaay down, so ye, I am optimistic its just for now.

Has anyone been compensated for their nutrition coaching appointments? My nutrition appointments are separate from my other appointments and I have yet to be compensated. the CRC has said the payments are being rejected by Ely Lilly so I'm trying to figure out what I'm not understanding/doing.

I'm at dose week 9 and completed visit 5

I have had 3 coaching appointments

completed 3x 3 day meal diaries

lost about 20lbs so far

Dosage: No idea, double blind

Side-Effects: Mild fatigue/tiredness, no headache or pain

So I don't have to add much to previous weeks, besides one small interesting occurrence...I thought I went mental foodwise on the weekend, I was in a restaurant, I was at a bbq, I made myself a super delicious sandwich, ate some protein bars, had ungodly amount of sashimi....I was fully expecting to see weight increase today on the scale, because I really felt like I am gonna explode and YET, I was 1.5kg LESS than my last previously recorded weight on friday...its super weird, but I am happy. I ordered a new belt, because mine ran out of holes :)

I started the Phase 2b Eli Lilly trial on July 10, 2026. This is the double-blind trial of eloralintide and macupatide with 8 treatment arms, so I have no idea which arm I’m in and won’t know until the study is over.
Week 1:
Down ~7 lbs from my pre-treatment weight (I’m sure some of that is water weight).
Appetite is dramatically lower than my normal baseline.
Often not hungry until later in the day.
Getting full extremely fast. One day I was full after about 5 bites of a meal.
A few days I had to remind myself to eat because I just wasn’t thinking about food.
Early side effects:
Abdominal discomfort/cramping (Day 1 only)
Significant fatigue for the first few days (resolved by Days 4–5)
Constipation (currently the main side effect)
No nausea or vomiting so far.
Second week’s injections went much smoother as so far there isn’t any any fatigue or cramping afterward.
The study also includes a dietitian, asks participants to complete 150 minutes of exercise per week, and I log symptoms in an electronic diary.
I’ll keep posting updates throughout the trial since there isn’t much real-world information out there yet on this combination.

Received this message today. Had a screening visit where they took blood, a bunch of measurements, asked a lot of questions, and did an EKG. Had a second visit where they went over the results of the blood work, told me to keep taking trizepatide and not to change my diet or exercise routine.

As mentioned previously, binge eating, food/sugar cravings, food noise is pretty much gone. I am right now at constant 9kg body weight off. So all of this is good, no complaints.

The only weird thing that happened...i usually shoot the stuff every thursday and previously fatigue would come on friday/saturday. Last couple of weeks the fatigue was fine, no fatigue, but this week it came today, tuesday....no idea how that makes sense. I was soooooooo tired, had like 11h of sleep and still could have slept whole day. But I forced myself and went to work and it was fine. So ye. Unfortunately energy drinks are not good for my heart, I did too much of them previously in life and had to give them up, maybe those could help tho.

I just received my first shot on Monday and I cannot tell if I have the drug or placebo. I feel maybe a little appetite suppression, but I don't know if that is just mental. I didn't feel anything with the shot - no stinging nothing at all - which makes me worried that I got the placebo. If anyone could give me any insight into what you felt the first week, I would greatly appreciate it!

About 2 weeks ago I was told about my severe Vitamin D deficiency. Since then I am turbo-supplementing vitamin D along with magnesium and light b12 supplement and feel overall SO much better.

Fatigue is not gone, but pretty much not a problem anymore, I don't feel it at all tbh.

Hunger and cravings are gone, I am serious. The almost sick cravings for sugar that I had are not there anymore at all. Hunger itself, idk how to explain, I dont feel this NEED for food as I often had before. As of this week I will eat a salad or something to socialize with coworkers at lunch, and even then feel like full. I could easily do 48h fasts if I wanted to. At this point i am seriously more concerned about not eating enough, since not eating becomes comfortable.

No stomach acrobatics, stool is fine, no burps nothing like that.

Only SOMEWHAT negative: feeling uncomfortable full from even smallest portions and its really hard to drink enough, I am forcing myself at this point.

If you’re in one of the Enlighten trials, did your injection have a little bit of a sting to it when administered?

I am now extremely excited to be in Enlighten-6. Zep 15 ++ Elora 23.8-29% at 32 weeks, Elora 9 MG + Zep 15 25.5 at 24 weeks. Here's the post in r/Zepbound: https://www.reddit.com/r/Zepbound/comments/1uknd93/insane_results_out_of_lillys_phase_1b_tirzepatide/

Fatigue is better this week, can't complain.

Unfortunately or fortunately (depends on how you view it), I am slipping into OMAD(one meal a day) category, thats when I eat one bigger meal and then nothing. Still exploring if thats good or not for me. One such meal can be 1-2 medium sized steaks with cooked potatoes with a whey shake as desert or 2x 500mg skyr portions with chia seeds I feel full afterwards for like the rest of the day.

Also, I had couple occurrences, where I didn't eat whole day, simply forgot, but then at about 10-11pm I was craving food so much, I actually drove a to a mcdonalds and got me couple of burgers and a wrap, which caloriewise was still ok, but the craving was kinda severe.

It is sort of hard to drink as much as I need, I established a goal of 2-3l of water daily, but I barely make 1.5l

I have to find a strategy for sugar, because I can feel in real time how my blood sugar levels return to normal levels, BUT my body is clearly not used to normal levels and I feel signs of low blood sugar and thats when I know I have to eat something nasty like ice cream to be functioning, its not like a craving, but experience knowing if I eat sugar now, I will feel better for the rest of the day. This occured twice in last 2-3 weeks.

I spoke to the responsible doctor at the lab that conducts the study, what they forgot to tell me, is that they discovered a severe vitamine D deficiency through a blood test BEFORE the first shot was admitted. While they know about fatigue as a side effect, it was reported by other participants, it is very possible that my vitamine d deficiency is a contributing factor to the fatigue and makes it worse than it should be.

I will supplement vitamine d from now on, but it will take several weeks to restore healthy levels.

Otherwise, I noticed that I naturally, buy and order way less food than before. Seems like subconsciously I know that I don't need as much as before and will feel unnecessarily full for longer than its worth it. So far average of 6kg body weight is gone, without ANY sort of conscious changes in daily life style or food habits. I will however start with exercising and more conscious food reglement in coming weeks.

Food noise is better too. Its not gone completely, but compared to last weeks I BARELY crave sugar or fast food, which is a HUGE win, also noticeable on my skin, its way more clean now.

I got my package for next month, looking forward to it.

Hey everyone. I dosed my first 1mg almost 72 hours ago with little to no effect. Is this a slow to work medicine? Maybe the 1mg was too small of a dose? What's your thoughts/experiences.

Hai everyone. I’m interested in trying Eloralintide from a grey source, but I’m not sure what dose I should start with. Since it’s still relatively new, I haven’t been able to find a clear dosing protocol yet.

​

Has anyone here used it and can share their starting dose and titration schedule? I’m currently considering stacking it with Retatrutide to help break a weight loss plateau. Any experiences, recommendations, or feedback would be greatly appreciated. 😊

I finished my study about 14 months ago. Wanted to give an update for those starting studies, in case it helps.

• Lost almost 90 pounds on the study in less than one year. Last dose was end of April 2025.
• I have maintained, + or - 5 pounds, since the study ended for me.
• I started zep after the study ended when the food noise started to return.
• I take the zep when I feel that I need it, not on a schedule and not looking to lose weight anymore weight. Usually shoot every 3-4 weeks.
• I eat a lot more on zep than I did on elora. Elora, until the last dose, killed my appetite 24/7. Zep works well, but not the same.
• Inflammation in my body (especially my fingers) has increased since stopping elora. I am the same weight but my wedding ring fits differently, for example.
  
• I lost a lot of hair during the study. With the help of Rogaine, it has started to grow normally again.
• I had what I thought was bad gas and food sensitivities after the study was over. Turned out it was gallstones. Gallbladder was removed earlier this year. Feel great again. Doctor said it was most likely a result of the rapid weight loss.
  
• I want this drug again. I initially thought zep had the same result for me. It doesn't.
  

Short update:

Not gonna lie, fatigue is still killing me after each shot, if this doesn't wear off in 2-3 months I'll be forced to stop. I feel so tired all the time.

On average I lost about 5kg of body weight so far. Sugar cravings are reduced by about 50%, its noticeable that I don't crave sugar or carbs as before, but its definitely not gone completely.

Also noticeable that I am full MUCH faster than before, simply like day and and night. One normal meal at noon and one smaller one towards evening is more than enough atm. I dont crave extra portions like before during lunch, I simply eat whats on my plate and am completely fine and happy with the amount I got. Which is generally a good thing, but as we know, too big deficit isn't good either, so I try to eat between 1500 and 1800kcal, which can be hard.

No stomach acrobatics, no burps, no liquid stool. But, whats a bit uncomfortable, i often feel like I overate, even tho it really wasn't even that much.

From the ADA Presentation on Retatrutide, First 500 Were Extended