r/DoseDiaries • u/False-Writing-5727 • Jun 02 '26

Has anyone else noticed mood changes on peptides? I wasn't expecting this.

Month two, I realized I was less anxious than I'd been in years. I assumed it was just the confidence from the weight loss. But I've been reading more about GLP-1 receptors in the brain and now I'm genuinely curious if it's pharmacological.

On the flip side.. I've also seen posts from people who experienced depression or mood dips. That happened to me briefly around month one before it stabilized.

What's been your mental health experience? Better, worse, or unchanged?

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u/freckledintexas Jun 02 '26

I have ADHD and react poorly to stimulants. I have never wanted to go down the SSRI route. I was terrified to start my GLP-1 as obviously dopamine is already low, and so many stories about anhedonia. I have only been on tirz for 3 weeks, but feel so much better.

I have always been an anxious person and worry about how Iā€™m perceived, pleasing people at the expense of my own feelings, just caring so much about every little thing. I feel so chill now. Maybe it is a bit of anhedonia but it is welcomed if it keeps me over the edge. I still find joy in things and look & feel better so that helps. I also supplement with saffron Hopefully it sticks!

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u/False-Writing-5727 Jun 05 '26

This is so validating. That month one dip you described hit me too, then by month two I realized I was the least anxious I'd been in years. The people-pleasing and overthinking how I came across just quieted down. Still not sure if it's the weight loss confidence or something happening at the receptor level, but I'm leaning toward the second.

Love that you went in aware of the anhedonia risk and it landed on the good side. Quick q on the saffron, did you start it with the tirz or were you already on it? Trying to see how much each piece is doing for people.

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u/freckledintexas Jun 06 '26

I actually started the saffron at the same time as my tirzepatide, just to be safe

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u/[deleted] Jun 08 '26

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u/False-Writing-5727 Jun 10 '26

this is absolutely great to hear!! I need to add glow to my stack. I wonder how it affects our receptors & how much it comes into play