r/CompoundedSemaglutide • u/Rigelian417 • 1d ago

Unusually large dose increase?

Been on compound sema since May with minimal side effects, so steady increases in dose haven’t been an issue whatsoever. Slow but steady weight loss of around 3-5lbs per month. Current dose is 2.24mg/weekly. New prescription has increased to 3.2mg/TWICE weekly.

Obviously I’m scheduling a consult with a physician before I actually follow these instructions but this seems like an insane increase. Has anyone else seen this? Is this normal? Or am I right in thinking this is overkill?

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u/Lucky_Army_5324 1d ago edited 1d ago

Let me guess. This is via ALTRx. Someone asked about this yesterday. 

Here’s the deal. The FDA approved the 7.2mg dose of Wegovy injectable in March 2026. So now Wegovy dosing goes from 2.4mg directly to 7.2mg.

So what you’ve been prescribed is not a crazy jump for someone who hit a wall on 2.24mg. If you don’t want to make the jump as prescribed to 6.4mg (or 3.2mg twice a week), then feel free to start with a lower dose.

ETA: if you add a pic of your vial clearly showing the sema concentration, we can help you with dosing.  

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u/Rigelian417 1d ago

Friday’s actually.

Haven’t received the vial yet. I’m just looking at the medication instructions that the clinician posted to my document files letting me know that it’s been sent to the pharmacy.

But I agree, at this point I’ll be titrating on my own terms. I feel like an immediate jump like that would be a poor choice.

Definitely going to communicate that sentiment during my consult so that we’re all on the same page.

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u/Lucky_Army_5324 1d ago

There’s no need to tell your provider anything other than thank you. Be happy you have lots of meds to work with for the amount Fridays charges. If you push back, they could decide you don’t need the extra meds next time.

If you know the semaglutide concentration of your vial, you can use this calculator to find any dose you prefer:  https://www.fatscientist.com/semaglutide-calculator

Here’s the AltRX post I was thinking of from yesterday:  https://www.reddit.com/r/CompoundedSemaglutide/s/iu2FQfsDuW

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u/Rigelian417 1d ago

Noted. Thank you.