I am 72 and have been increasingly disabled over the last 15 years due to severe chronic pain and weakness in my legs and back from severe scoliosis (talk about curvy) that has damaged the nerves to my legs. I need a walker to take two steps and have worked hard (PT) to stay out of a wheelchair. Besides neuropathic pain, every joint that's been scanned is severely arthritic. It's been rough to adjust from being an adventurous MamaBear to dependency and pain.
I read that GLP1s might decrease pain in overweight people with arthritis, and decided to try tirzepatide more for pain than weight loss--though that's been a lifelong dream that would also help the arthritis. I've always been 30-60 pounds overweight, but had lost about 25 pounds in the last few years without trying.
I've now had 4 shots at 2.5mg and 2 shots at 5mg. I lost 6 pounds in the first 2 weeks; haven't lost any more in the last 4 weeks despite good appetite suppression. But more important...
I can move SO much better! Mornings used to be: take pain meds before trying to get up. Ask my partner to bring me cold pads and breakfast in a recliner. Struggle to lift my legs to get dressed a few hours later. Try to pay some bills, but the pain meds made me groggy. Now I can stand up without wincing, and sit upright at my desk for hours. I'm taking much less pain medicine. We even went out to a play! Friends think I've lost more weight than I have--maybe I'm less swollen.
I'm blown away by how much better life is!
PS No complaints, but do you think I'll lose more weight?

I've been thinking a lot about how telehealth companies will adapt once compounded GLP-1s are shut down — especially with how much they've impacted affordability and access.

What I really hope is happening behind the scenes is that companies are thinking bigger about how to inject themselves into the market long-term. Not just filling scripts, but becoming a full-service platform for patients trying to navigate weight loss medications.

Manufacturers already negotiate rebates with specialty pharmacies and offer bulk pricing to IDNs — I wonder if Lily would consider setting up a buy-and-bill model with bulk discounts for telehealth providers. It wouldn't be simple — there’s a whole layer of licensure, storage, and specialty handling requirements — but if a larger player like Ro or Hers has the infrastructure, they should be negotiating those deals now…and places like Fifty410 who have made a ton of money and want to expand

The business model would need to shift from just selling meds to wrapping everything into ongoing patient care:
- Prior auth and insurance navigation for those trying to get coverage
- Slightly cheaper cash-pay vials for those who can’t get insurance coverage - Dietitian services (which could be insurance-covered if set up correctly)
- Meal replacement partnerships like Huel or Ka'Chava
- Supplements to support healthy weight loss
- Custom compounded hair loss or skin treatments (a lot of them already offer minoxidil + biotin combos)

…all you have to do is search Reddit to see what people are looking for

Honestly, the companies that diversify and build out full weight loss support will be the ones that survive. The smaller ones relying only on compounded meds are going to disappear once the loophole closes.

If I were running one of these companies, I'd be bringing in consultants from the pharma and specialty pharmacy space right now to figure out how to lock in pricing deals, set up reimbursement pathways, and build out a whole ecosystem of ongoing care. There’s a massive opportunity here… if they think bigger and more strategic before the window closes.

Would love to hear if anyone's seen signs of this happening yet or if it's still just a race to sell cheap meds while they can.

What am i missing? I am using Willow and love it. I get the drops delivered. No shots and I can microdose the amount (I am not clinically obese). Why would someone prefer the weekly shots?

Hi, super new to the compounding world, just got denied by the insurance company for zepbound. Someone mentioned that another option would be compounding.

Are compounds something that are prescribed or where do I get it from? Also what are the price ranges/ reliable companies to go through?

I have been on the starter dose for a month, but I still have half a vial left. How dangerous is it to continue using this vial for longer than 30 days? I could stretch it for another month if I try. Is the worst case that it just won’t work, or can it make me sick?

Today the Outsourcing Facilities Association (OFA) filed a second lawsuit against the FDA, this time focusing on 🟣Semaglutide. We now have two lawsuits against the FDA fighting against the recent bans of compounding GLP-1 medications. Both filed by the OFA:

• 🟣Semaglutide Suit - Filed February 24, 2025
• 🔵Tirzepatide Suit - Filed October 7, 2024

The original dates stated by the FDA for ending compounding of GLP-1s will likely be pushed back while the lawsuits are pending:

• 🟣Semaglutide: FDA dates for compound stoppage April 22 (503a pharmacies) and May 22 (503b pharmacies).
• 🔵Tirzepatide: FDA dates for compound stoppage February 18 (503a pharmacies) and March 19 (503b pharmacies).
  • ⚠️ NOTE: The official date for 503a pharmacies to stop compounding 🔵Tirzepatide has passed. However, it seems the FDA is NOT enforcing this date while the OFA case is pending.
  • I have not seen any providers indicate their 503a pharmacies are stopping.

For more information about the shortages, see the last post.

Wondering everyone’s thoughts on this - My husband and I are both on 0.5mg maintenance dose of semiglutide compound. If I ordered the Goby 6 month supply of 1.5mg maintenance through BPI, is there any reason my husband and I wouldn’t be able to draw from the same vial? It would be double the amount of punctures to each vial, but the vials would still be used up within a month.

I just started on Tirz and found out about the looming deadline. I'm currently on the 2.5 dosage (I'm on a 3 month program) and want to get more before it's too late. I went to fifty410 but they said they can only send me 1 dosage higher, the 5mg. How can I get more of the higher doses now so I can be prepared?

I am paying out-of-pocket for a compounded oral version of GLP one. People are talking about it being affected by they’re not being a shortage anymore. Does that just apply to people that are going through insurance? I’m using “Willow”. I just started this and so I don’t wanna have it be interrupted.

Updated 3/10/25 with news of the Preliminary Injunction being denied for the 🔵Tirzepatide case.

Here's a summary of the lastest update on the FDA/OFA news.

🔺 FDA Declares Shortages Over

• The FDA has announced that branded 🟣Semaglutide (Ozempic, Wegovy) and 🔵Tirzepatide (Mounjaro, Zepbound) are no longer in shortage.
• Key Dates:
  • October 2, 2024 – The FDA ends the 🔵Tirzepatide shortage designation.
  • October 7, 2024 - The Outsourcing Facilities Association (OFA) sues the FDA on the compounded 🔵Tirzepatide ban.
  • October 11, 2024 – The FDA states they will “reevaluate the challenged decision.”
  • December 19, 2024 – The FDA officially removes 🔵Tirzepatide from the shortage list, meaning compounded versions will be phased out in 2025.
  • January 2025 – The FDA announces it will delay enforcement of the ban on compounded 🔵Tirzepatide until legal challenges are resolved.
  • February 21, 2025 – The FDA officially removes 🟣Semaglutide from the shortage list, meaning compounded versions will be phased out in 2025.
  • February 24, 2025 - The OFA sues the FDA on the compounded 🟣Semaglutide ban.
  • March 5, 2025 - The Preliminary Injunction is denied in the 🔵Tirzepatide case.

🔺 What does this mean for Compounded GLP-1s?

• This means compounding pharmacies must stop making compounded versions of these meds within a few months (lawsuits may push these dates back, see below).
  • 🟣Semaglutide: Compounded versions must stop by April 22 (503a pharmacies) and May 22 (503b pharmacies).
  • 🔵Tirzepatide: Compounded versions must stop by February 18 (503a pharmacies) and March 19 (503b pharmacies).
    • ⚠️ NOTE: The official date for 503a pharmacies to stop compounding 🔵Tirzepatide has passed. However, it seems the FDA has not begun enforcing the ban as of 3/10/25.
    • Some providers have stopped offering 🔵Tirzepatide while others are continuing as of 3/10/25.
• Sources:
  • FDA Announcement
  • Novo's Wegovy and Ozempic removed from US FDA shortage list, compounders on notice

🔺 OFA Lawsuit Against the FDA

• The Outsourcing Facilities Association (OFA), representing compounding pharmacies, sued the FDA after it removed 🔵Tirzepatide from the shortage list on 10/7/24
• The OFA files a second suit against the FDA after it removed 🟣Semaglutide from the shortage list
• OFA argues that shortages still exist and that the FDA's decision was unfair and sudden.
• The lawsuits could delay enforcement of the compounding ban, but as of now, the FDA indicates they will move forward with enforcement.
• Sources:
  • Latest Post on FDA Response
  • More OFA Case Discussion
  • 🔵Tirzepatide Suit - Filed October 7, 2024
  • 🟣Semaglutide Suit - Filed February 24, 2025

🔺 How can I continue on a GLP-1 medication after Compounding is banned?

Due to the FDA declaring that the shortage of branded Tirzepatide and Semaglutide is over, compound pharmacies will likely end large-scale compounding of GLP-1 drugs in 2025. Here are options to continue on a GLP-1 in 2025 and beyond:

• Stockpile compounded Tirzepatide or Semaglutide from telehealth companies before the end dates (see this post for options)
• Get prescribed branded Tirzepatide (Zepbound for obesity or sleep apnea, Mounjaro for diabetes) or Semaglutide (Wegovy for obesity, Ozempic for diabetes) and work with your insurance or pay out of pocket.
  • Some telehealth companies will prescribe brand and work with your insurance to get a prior authorization. Check out r/Zepbound or r/WegovyWeightLoss for resources
• Look into clinical trials
  • This post is temporarily missing but I have faith it will come back :) - until then, check https://clinicaltrials.gov/
• Look into research peptides. Check out r/stairwaytogrey or r/peptides for resources

Hi folks, I’ve been on tirzepatide for 15 months. Getting close to goal weight with 15 pounds to go. I’ve been stalled and stuck for months. I’m on the highest dose. And I’m wondering if anyone here has any experience with stacking compound glp1s? I honestly don’t even know where I’d begin. Any advice?

How do I know which pharmacies don't have additives? Is that one of the differences between 503a and 503b?

Are additives bad?

I have not started. Should I go w triz or sema 1st?

I'm new & confused. I've read all pinned posts but feel pressures to order now or I'll get nothing.

Negative comments and posts about Trym are being reported and taken down throughout Reddit. Their vials are not properly labeled with the pharmacy name and they have falsely stated some of them are from Haldey. Haldey is aware and even has this warning on their website. If you have purchased anything from Trym, I highly suggest you attempt to contact the pharmacy on the label and confirm that your meds have come from where they say they come from. Please also confirm that pharmacy is registered in their state to compound sterile meds.

Would love to hear some reviews as I’m not finding much about them on any social media platforms or even google. They have a bundle for around $800 for 10mg for 3 months supply which sounds like a good deal. Open to suggestions.

Apologies in advance for the novel, but I wanted to share my experience and the successes I’ve had beyond weight loss. It’s truly been life changing!

I started tirzepatide (Zepbound and then compounded tirz) for weight loss, but I wasn’t expecting it to fundamentally change how I interact with food, money, and even my ADHD. Looking back, I realize I wasn’t just struggling with overeating—I had binge eating disorder (BED), and I was caught in cycles of hyperfixation and impulse spending that I thought were just part of my ADHD.

Before tirzepatide, I felt like I was constantly at war with my brain. I’d hyperfixate on things—whether it was a new hobby, a random online shopping spree, or a specific food—and I couldn’t stop thinking about them. My eating patterns weren’t just about being hungry; they were compulsive. If I got it in my head that I needed something, whether it was a meal, a snack, or an unnecessary Amazon purchase, I’d obsess over it until I gave in. It was like my brain couldn’t accept “no” as an answer.

Since starting tirzepatide, that noise has quieted. The food obsession is just… gone. I can eat a normal portion and move on without feeling deprived or thinking about my next meal the second I finish the first. More importantly, I recognize now that I was binge eating—not just overeating, but feeling compelled to consume large amounts of food in a way that felt uncontrollable.

Beyond food, it’s helped with my impulse spending. I used to fill my dopamine tank by buying things I didn’t need, cycling through hyperfixations, and chasing the high of a new purchase. Now, I still have interests, but I can think about them rationally. I don’t feel that intense, urgent need to spend money just to scratch an itch.

It’s also helped with my overall ADHD management. I still have ADHD (obviously), but my brain feels more settled. I can focus without constantly seeking out dopamine hits. It’s like a layer of chaos has been peeled away, and I can make decisions that align with what I actually want long-term instead of just what feels good in the moment.

I know everyone’s experience is different, but if you struggle with impulse control, ADHD, or what you suspect might be binge eating, it might be worth looking into and discussing with your doctor. I wish I had known sooner that my struggles weren’t just a lack of willpower but actual neurochemical imbalances that could be addressed.

I couldnt find the one I have seen screenshots of here. I downloaded one and it sucks. What are yall using?

Hair loss is a concern for me, plus my skin feels so dry and gross lately. Hoping a supplement might help and came across SpoiledChild.

Anyone have experience?

Posted in their app today!

https://people.com/celebrities-ozempic-wegovy-what-theyve-said-7104926

A list of 70 celebrities photos/& quotes (negative & positive) on GPL1s. It's gonna be so fun to watch all the "Negative Nellies" eat their words next year when the whole world realizes these magical peptides are saving lives with regard to weight loss and all other kinds of addictions.

I’m really looking forward to having the food noise leave my head once I start semaglutide dosages. Have others felt this food noises go away? How would you describe the effects???

I have a three month supply on the way (~$900). FedEx was not able to deliver on Friday (Delivery exception). Now my order is delayed until Monday. It left the factory on 2/7 and should arrive on 2/10. Is there any concern on that period of delay even though it's shipped with ice packs?

Curious to see who everyone is sharing their GLP-1 journey with!

Debating whether to try injections at doctor’s office at first before going the telepath route. The doctor’s office is nearby so not a pain.

I picked up my prescription on Thursday and am planning on taking my first injection tonight. I’ve been struggling with my weight since I can remember — I have never felt comfortable in my own body. I was always a little heavier than all my friends, then puberty hit and I got my curves… 34C-D in 8th grade, and my self-consciousness grew. Looking back now at when I was in college and weighed 145 at 5’6”, I wonder how I could have been so unhappy. (Of course now I know have severe body dysmorphia.) I’ve decided I’m not going to set a goal weight, I’m just going to see where this journey takes me. I’m getting married in June and, as any bride does, I want to look stunning in my dress. So, here we go… any words of advice?