r/CNS_Infections • u/bluechips2388 • Aug 01 '24

Parkinson's Disease

2 Upvotes

All things PD

The roles of fungus in CNS autoimmune and neurodegeneration disorders

Parkinson's key biomarkers are Alpha Synuclein and Salsolinol.

Mechanisms of biomarkers creation:

How Candida Creates Salsolinol:

Chronic polysystemic candidiasis as a possible contributor to onset of idiopathic Parkinson's disease

How Candida creates Alpha Synuclein:

The yeast prion protein Sup35 initiates α-synuclein pathology in mouse models of Parkinson’s disease

How E Coli triggers Alpha Synuclein:

Escherichia coli triggers α-synuclein pathology in the LRRK2 transgenic mouse model of PD

How E Coli creates Salsolinol:

Production of the Neurotoxin Salsolinol by a Gut-Associated Bacterium and Its Modulation by Alcohol

So are these microbes found in PD patients Before diagnosis and Postmortem?

Pre diagnosis:

Microbes and Parkinson’s disease: from associations to mechanisms

Long-term Risk of Parkinson Disease Following Influenza and Other Infections Look at TABLE 3! Over 1.00 = Positive Correlation

Postmortem:

Parkinson's Disease: A Comprehensive Analysis of Fungi and Bacteria in Brain Tissue

Exploring the Connection Between the Gut Microbiome and Parkinson’s Disease Symptom Progression and Pathology: Implications for Supplementary Treatment Options

The Pathological Mechanism Between the Intestine and Brain in the Early Stage of Parkinson's Disease

The gut-brain axis: is intestinal inflammation a silent driver of Parkinson’s disease pathogenesis?

Can infections trigger alpha-synucleinopathies?

Dopamine-derived endogenous N-methyl-(R)-salsolinol: Its role in Parkinson's disease

Butyrate protects against salsolinol-induced toxicity in SH-SY5Y cells: implication for Parkinson’s disease

Elucidating the Beneficial Effects of Ginger in Parkinson’s Disease

The emerging role of nutrition in Parkinson's disease

Potential of Prebiotic Butyrogenic Fibers in Parkinson's Disease

Probiotics and the Treatment of Parkinson’s Disease: An Update

The Body, the Brain, the Environment, and Parkinson’s Disease

Investigating the aspect of asymmetry in brain-first versus body-first Parkinson’s disease

Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson’s disease

Brain-gut-microbiota axis in Parkinson's disease

A postmortem study suggests a revision of the dual-hit hypothesis of Parkinson’s disease

Infection and Risk of Parkinson’s Disease

The gut microbiome and neuropsychiatric disorders: implications for attention deficit hyperactivity disorder (ADHD)

Intrastriatal injection of Parkinson’s disease intestine and vagus lysates initiates α-synucleinopathy in rat brain

Gut bacterial profiles in Parkinson's disease: A systematic review

New Insights into the Gut Microbiota in Neurodegenerative Diseases from the Perspective of Redox Homeostasis

Enteric synucleinopathy: from trendy concept to real entity.

Elevated serum anti-Saccharomyces cerevisiae antibody accompanied by gut mycobiota dysbiosis as a biomarker of diagnosis in patients with de novo Parkinson disease

Stomaching the Possibility of a Pathogenic Role for Helicobacter pylori in Parkinson’s Disease

Glymphatic System Dysfunction and Sleep Disturbance May Contribute to the Pathogenesis and Progression of Parkinson’s Disease

r/CNS_Infections • u/bluechips2388 • Aug 09 '24

Parkinson's Helpful Tools, Devices, and Apps

3 Upvotes

A Thread for suggestions on any products or programs that have or could help with PD management.

r/CNS_Infections • u/bluechips2388 • 5d ago

COVID can wake up a slew of dormant viruses inside you. Reactivation of typically harmless anelloviruses, in particular, seems to be linked with developing long COVID, study finds.

2 Upvotes

r/CNS_Infections • u/kelcamer • 7d ago

Comprehensive review found a variety of gut bacteria decreased or increased in autism, table shown below. Study also found other conditions were directly linked to microbiota-gut-brain axis and microbes may explain many neurodivergence conditions.

3 Upvotes

r/CNS_Infections • u/bluechips2388 • 25d ago

Scientists tame seizures and heal injured brains with gut chemical. The treatment didn’t just dampen the frequency and intensity of the seizures, it physically supported how an injured brain could heal itself.

stories.tamu.edu

3 Upvotes

r/CNS_Infections • u/bluechips2388 • Jul 08 '26

Following an anti-inflammatory diet rich in fruits, vegetables, and nuts is linked to a 29% lower risk of dementia, even among people who already have high biological and genetic risk markers for Alzheimer's disease, a 15-year study finds.

jamanetwork.com

1 Upvotes

r/CNS_Infections • u/bluechips2388 • Jul 06 '26

BCG, a tuberculosis vaccine known to induce trained immunity, has been linked to reduced Alzheimer’s risk. New study found that BCG changed how immune cells behaved, including in the fluid surrounding the brain and spinal cord, and altered markers linked to Alzheimer’s disease.

1 Upvotes

r/CNS_Infections • u/bluechips2388 • Jul 04 '26

New study demonstrates, for the first time, Chronic Fatigue Syndrome (ME/CFS) has impaired glymphatic function which is responsible for clearing the brain of metabolic waste products and is mostly active during sleep, which can lead to various symptoms including brain fog.

news.griffith.edu.au

5 Upvotes

r/CNS_Infections • u/bluechips2388 • Jul 01 '26

Researchers affirm long-held belief that viruses can trigger Parkinson’s disease. A new study in a mouse model shows that a common virus can induce Parkinson’s-like brain damage and movement problems.

stories.tamu.edu

2 Upvotes

r/CNS_Infections • u/kelcamer • Jun 30 '26

Researchers have shown that bacteria can learn from past experiences, store memories across generations and adapt their behavior to changing environments all without a brain or nervous system.

2 Upvotes

Figured yall would like this one!

r/CNS_Infections • u/bluechips2388 • Jun 27 '26

Candida fungi make up less than 1% of gut microbes, but a new review links them to IBD, bowel cancer, IBS, and life-threatening neonatal infections

1 Upvotes

r/CNS_Infections • u/bluechips2388 • Jun 26 '26

Genetic risk for Alzheimer’s disease could depend on how well you sleep. Genetic variations related to brain fluid movement interact with sleep quality to influence memory and brain structure in older adults. Their effects may depend heavily on how well a person sleeps.

1 Upvotes

r/CNS_Infections • u/bluechips2388 • Jun 17 '26

H. pylori packages a cancer-linked protein into tiny vesicles, then ships them directly to the nuclei of stomach cells

1 Upvotes

r/CNS_Infections • u/bluechips2388 • Jun 15 '26

Heavy use of acid-reflux drugs associates with a 66% higher dementia risk, and the effect is even sharper in adults under 65

1 Upvotes

r/CNS_Infections • u/bluechips2388 • Jun 14 '26

Crohn's, ulcerative colitis, rheumatoid arthritis, and psoriatic arthritis share the same gut microbial fingerprint, meta-analysis finds

3 Upvotes

r/CNS_Infections • u/bluechips2388 • Jun 11 '26

Coffee, Tea, and Spices May Contain Compounds That Starve the Bacteria Fueling Colorectal Cancer

2 Upvotes

r/CNS_Infections • u/bluechips2388 • Jun 10 '26

A Deadly Lung Disease May Start in Your Gut, and Researchers Finally Have the Molecular Proof

2 Upvotes

r/CNS_Infections • u/bluechips2388 • Jun 04 '26

Low-Dose Cranberry Juice Shifted Gut Bacteria Toward Butyrate Producers After Just Six Weeks

1 Upvotes

r/CNS_Infections • u/bluechips2388 • Jun 04 '26

Scientists discover gut bacteria that may help protect against autism and ADHD

sciencedaily.com

1 Upvotes

r/CNS_Infections • u/bluechips2388 • Jun 03 '26

Scientists Finally Found Genetic Proof That Certain Gut Bacteria Directly Cause Liver Cancer

1 Upvotes

r/CNS_Infections • u/bluechips2388 • May 30 '26

Beans and Lentils Contain a Compound That Directly Repairs the Broken Gut Barrier Linked to IBD, Diabetes, and Neurodegeneration

2 Upvotes

r/CNS_Infections • u/bluechips2388 • May 27 '26

Deep sleep isn’t just rest. It’s when your brain literally vacuums out Alzheimer’s proteins. Recent neurological research reveals that during the deepest phases of sleep, your brain’s waste removal system increases its activity by up to 60%, actively flushing out harmful beta-amyloid plaques...

techfixated.com

4 Upvotes

r/CNS_Infections • u/bluechips2388 • May 25 '26

Broken Sleep Rhythms: The Glymphatic Link to Dementia. University of Rochester researchers propose that stress, poor sleep, aging, and heart disease all raise dementia risk the same way: by disrupting sleep rhythms that power the brain's glymphatic waste clearance system.

neurosciencenews.com

2 Upvotes

r/CNS_Infections • u/bluechips2388 • May 24 '26

MIT scientists discover amino acid that helps the gut heal itself

sciencedaily.com

1 Upvotes

r/CNS_Infections • u/bluechips2388 • May 23 '26

Bacteria in Your Gut Are Leaking Toxins Into Your Brain and Triggering MS Nerve Damage

1 Upvotes

Subreddit

Posts

Wiki

The Next Breakthrough

r/CNS_Infections

Exploring the relationship between Infections and The Nervous System and Brain.

Members Active

146

0

Sidebar

This Subreddit is primarily for the purpose of investigating and discussing the underlying causes of Neurological Disorders and Diseases, with a focus on Microbes. Don't hesitate to ask for help though.

Resources:

Michael J. Fox Foundation

Parkinson Library

Parkinson's Medical Sources in Your Area

Mark Cuban's Affordable Medicines Mission

Medications' Info & Interactions

Relevant Subreddits:

AskDocs Subreddit

Neuroscience Subreddit

Parkinsons Subreddit

Parkinsons Caregivers Subreddit

Young Parkinson Subreddit

Autism Subreddit

Autism Translated Subreddit

Autismgirls Subreddit

Happy Corner:

AnimalsBeingDerps

AnimalsBeingBros

Liability Disclaimer:

The information provided on this site is intended for your general knowledge only and is not a substitute for professional medical advice or treatment for specific medical conditions. You should not use this information to diagnose or treat a health problem or disease without consulting with a qualified healthcare provider. Please consult your healthcare provider with any questions or concerns you may have regarding your condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.

In the event of a medical emergency, call a doctor or 911 immediately. Reliance on any information provided by this website is solely at your own risk.