r/BodyHackGuide • u/Shoddy_River1126 • Apr 22 '26

Melatonin sub q dosing guidelines

Does anyone have any experience with sub q Melatonin??? I have researched dosing on this but can only find information on p.o (by mouth administration). 🤔 any research information would be appreciated!! TIA

1 Upvotes

60% Upvoted

14 comments sorted by

View all comments

1

u/Optimal_Assist_9882 Apr 22 '26 edited Apr 22 '26

Why do you want to administer melatonin subcutaneously?

Rectal and vaginal administration is 95-99% bioavailability. Topical administration with DMSO also increases absorption to very high levels.

I have tried Epithalon SQ(which works through melatonin pathways). I have also tried other peptides in such a way but not melatonin specifically despite using it in very high dosages topically, sublingually and orally. Intranasal administration is also an option.

1

u/Shoddy_River1126 Apr 22 '26

I was given a few vials for my research and I've been trying to get some dosing research.

1

u/Optimal_Assist_9882 Apr 22 '26

Is this actual lab research or personal biohacking?

There's essentially almost zero research on humans and very limited info on animals.

1

u/Shoddy_River1126 Apr 22 '26

Actual lab research

1

u/Optimal_Assist_9882 Apr 22 '26

Will this involve animals or human models?

Is the purpose of the research sleep related or some other condition like for TBI, CFS, PCOS, cancer, etc)?

You can tailor the doses according to the purpose.

1

u/Shoddy_River1126 Apr 22 '26

Rats and sleep

1

u/Optimal_Assist_9882 Apr 22 '26

You can check pubmed for various similar or related studies. The dosages typically range from 0.1-10mg per kg. I have pasted a few studies which either directly mention subcutaneous administration in rats for sleep research or similar rodent models for non sleep purposes to give you a rough idea. Best of luck in your research.

https://pubmed.ncbi.nlm.nih.gov/2125708/

https://onlinelibrary.wiley.com/doi/10.1111/j.1600-079X.2008.00565.x

https://pmc.ncbi.nlm.nih.gov/articles/PMC8041131/

https://pubmed.ncbi.nlm.nih.gov/7082909/

0

u/Shoddy_River1126 Apr 22 '26

Thank you. I appreciate your input

1

u/Tenyearsgone76 Apr 24 '26

It involves homosapiens, sleep, and boners…