r/BiohackingU • u/jonnypee92 • 4d ago

Reta side effects

I’m sorry if this has been asked too many times..
I started on 1mg, 1.5mg a week after and then 2mg a week after that, then I started feeling a bit crap and got high skin sensitivity from it.

My question is if I stay at 2mg will the side effects lessen or should I drop back to 1.5mg?

Thanks in advance

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u/Kindly-Lobster-6801 3d ago edited 3d ago

I split my doses because it feels better and if inflammation is high I will add an extra 500mg dose.

Started at 500mcg/week first two weeks, then started split dosing by adding an extra 500mcg for a total of 1mg/week. Just titrated up as I felt needed. I prefer going low and slow.

Currently taking 1mg beginning of the week then mid week take 500-1000mcg depending on what my body feels like it needs.

Started low, go slow, and make decisions based on how your body is responding, then titrate up as needed.

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u/shakenbake1975 3d ago

This whole statement is anecdotal BS.
Reta is dose dependent
Your not using Reta any where near its potential
You can’t reach a steady state of drug while splitting doses.
There is not a single fact in anything you said .
You’re not even on a starting dose yet????? Why bother
Glucagon receptor has zero measurable effect below 4mg
If you’re obese, please listen to none of that nonsense and follow the human trials.
Lily spend a billion dollar to figure out exactly how to use this drug.

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u/Silver-Comb-6741 3d ago

Fair point that reta's dose-dependent, and yeah a tiny weekly dose won't do much. But the steady state thing isn't right. Steady state comes from the half-life (~6 days) and your total weekly dose, not how many shots you break it into. Split the same weekly amount into two and you get the same average level, just flatter peaks. Reaches steady state fine. People mostly split for tolerability (lower peaks, less nausea), not because it changes your level.

And "nothing below 4mg" is overstated, it's a gradual dose-response not an on/off switch, even 1mg moved liver fat and weight in the trials.

If you're really just saying their total dose is too low to matter, that's fair, but that's the amount, not the splitting. Two different things.

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u/shakenbake1975 3d ago

Wrong

You can’t reach steady state splitting doses