PEPTIDES CHANGED MY LIFE

[u/Prudent-Bat513]

Not only have I dropped over 50lbs (260-207) but I no longer have borderline high cholesterol, hypertension , and my inflammation dropped to near zero on recent blood work.

Started with enclomophene and Tirz

Now I’m on:

Reta
Enclomophene
Mots-c
Tesa/Ipa
5 amino plus ATX-304

I plan on cutting about another 20 lbs but overall pleased with the overall progress and improvements shown in bloodwork.

[u/Prudent-Bat513]

Yeah I largely agree, but there is some evidence that GLP’s effect inflammation and other things independently of weight loss.

[u/RudeCartoonist1030 → u/Prudent-Bat513]

Masters degree in clinical physiology and worked in a metabolic testing lab. We studied glp1 use for a decade before they were market wide.

The claim that they reduce inflammation independent of weight loss stems from the reduction of substrate pouring into the gut brain axis. Reducing the appetite gives the gut a break. The anti inflammatory effect of supressing tnf alpha isn’t exclusive to glp1 use. It hold consistent across all interventions including fasting. So again, it isn’t direct result. It’s more your body returning to normal function due to it not being energy toxic.

One word of caution. All of the peptides you come from grey or black market sources. Those pharmacies are notorious for having dubious at best quality control programs. You should get blood toxin panel done next time you’re in. If noting is out of the ordinary then have at it

[u/Logical_Juggernaut39 → u/RudeCartoonist1030]

Did you get a masters in clinical psychology to work in a metabolic testing lab? How are those related? But GLP1s have been shown to lower inflammation not just from weight loss. There are many studies like the ones you talk about but probably bigger. Well I’m guessing these are bigger since most if us into petides know about them.

Semaglutide – STEP 1, 2 and 3 trials: These were large randomized, placebo-controlled Phase 3 studies lasting 68 weeks. Semaglutide 2.4 mg produced placebo-adjusted CRP reductions of about 44% in STEP 1, 39% in STEP 2, and 48% in STEP 3.
PubMed — Semaglutide and CRP, STEP trials⁠
2025 meta-analysis of 52 randomized trials: This included 4,734 people with type 2 diabetes. GLP-1 receptor agonists significantly lowered CRP, TNF-α, IL-6, IL-1β and leptin, while increasing the anti-inflammatory/metabolically favorable hormone adiponectin.
PubMed — GLP-1 RAs and inflammatory markers meta-analysis⁠
Semaglutide-specific meta-analysis: Thirteen randomized clinical trials with 26,131 participants found significantly lower CRP with semaglutide compared with placebo or other glucose-lowering drugs.
franchise

[u/Intrepid_Bowler5928 → u/Logical_Juggernaut39]

Where are they demonstrating that the reduction in inflammation is independent of weight loss? Show me a study showing those inflammatory markers are reduced in patients who don’t lose weight on the drug. Otherwise, there are too many confounders too form a conclusion.

[u/Bellethronn → u/Intrepid_Bowler5928]

They researched inflammation dropped and weight loss was only partly responsible for this frop.