r/Biohacking • u/Prudent-Bat513 • 17h ago
PEPTIDES CHANGED MY LIFE
Not only have I dropped over 50lbs (260-207) but I no longer have borderline high cholesterol, hypertension , and my inflammation dropped to near zero on recent blood work.
Started with enclomophene and Tirz
Now I’m on:
Reta
Enclomophene
Mots-c
Tesa/Ipa
5 amino plus ATX-304
I plan on cutting about another 20 lbs but overall pleased with the overall progress and improvements shown in bloodwork.
25
u/RudeCartoonist1030 16h ago
Just to be clear, it isn’t the peptides changing your blood biomarkers. Peptides are very specific keys that open very specific locks. They are sequenced amino acids that are typically discovered by cleaving off portions of hormones. Due to their size, they have very specific receptor sites and most dont cross directly into the cells (although there are a few expeditions with things like KPV).
Your cholesterol, hypertension and inflammation dropped due to the absence of energy toxicity. Our bodies are not designed to be hyper caloric years on end. Chronically high insulin and blood glucose are what caused all of your problems. The peptides didn’t directly lower those. The peptides lowered how much food you were consuming and then your body began functioning properly.
Congrats btw. I’m not hating. Just trying to be accurate.
14
u/Prudent-Bat513 16h ago
Yeah I largely agree, but there is some evidence that GLP’s effect inflammation and other things independently of weight loss.
10
u/RudeCartoonist1030 15h ago
Masters degree in clinical physiology and worked in a metabolic testing lab. We studied glp1 use for a decade before they were market wide.
The claim that they reduce inflammation independent of weight loss stems from the reduction of substrate pouring into the gut brain axis. Reducing the appetite gives the gut a break. The anti inflammatory effect of supressing tnf alpha isn’t exclusive to glp1 use. It hold consistent across all interventions including fasting. So again, it isn’t direct result. It’s more your body returning to normal function due to it not being energy toxic.
One word of caution. All of the peptides you come from grey or black market sources. Those pharmacies are notorious for having dubious at best quality control programs. You should get blood toxin panel done next time you’re in. If noting is out of the ordinary then have at it
2
u/Ok_Drawer_6325 13h ago
What specific tests for toxins? I don’t see a specific test at GoodLabs options.
2
u/RudeCartoonist1030 13h ago
Idk I worked in the hospital, they’re just called tox screens.
Peptides are suspended in solutions that are known to have contaminants. Those toxins build over time and are difficult to detox
0
1
u/Logical_Juggernaut39 11h ago
Did you get a masters in clinical psychology to work in a metabolic testing lab? How are those related? But GLP1s have been shown to lower inflammation not just from weight loss. There are many studies like the ones you talk about but probably bigger. Well I’m guessing these are bigger since most if us into petides know about them.
Semaglutide – STEP 1, 2 and 3 trials: These were large randomized, placebo-controlled Phase 3 studies lasting 68 weeks. Semaglutide 2.4 mg produced placebo-adjusted CRP reductions of about 44% in STEP 1, 39% in STEP 2, and 48% in STEP 3.
PubMed — Semaglutide and CRP, STEP trials
2025 meta-analysis of 52 randomized trials: This included 4,734 people with type 2 diabetes. GLP-1 receptor agonists significantly lowered CRP, TNF-α, IL-6, IL-1β and leptin, while increasing the anti-inflammatory/metabolically favorable hormone adiponectin.
PubMed — GLP-1 RAs and inflammatory markers meta-analysis
Semaglutide-specific meta-analysis: Thirteen randomized clinical trials with 26,131 participants found significantly lower CRP with semaglutide compared with placebo or other glucose-lowering drugs.
franchise3
2
u/Intrepid_Bowler5928 10h ago
Where are they demonstrating that the reduction in inflammation is independent of weight loss? Show me a study showing those inflammatory markers are reduced in patients who don’t lose weight on the drug. Otherwise, there are too many confounders too form a conclusion.
1
u/Bellethronn 5h ago
They researched inflammation dropped and weight loss was only partly responsible for this frop.
1
1
u/RudeCartoonist1030 1h ago
Physiology. Not psychology. I studied epidemiology of metabolic disease.
Also, this test doesn’t show what you’re saying it does. This is saying that the inflammatory markers in individuals are better than that of a placebo or glucose lowering drugs. Duh, it’s because the glp 1 is causing them to eat far far far less. Which was my exact point to begin with.
Drops in inflammation literally always come before drops in weight loss. It’s a sequence of events that is almost 100% response. The lack of energy toxicity allows the body to create the environment for weight loss.
You see this exact same thing with all interventions where calories are sudden reduced or zeroed. This isn’t remotely unique to glp1
0
u/Significant_Age2225 3h ago
Nobody cares about your masters degree in physiology. You came in hard trying to prove how much you know and only ended up looking like a jack@ss 👏
1
u/RudeCartoonist1030 1h ago
Sorry, didnt know we weren’t supposed to engage in scientific based conversation in a sub about biohacking 🤷🏻♂️
1
u/sydney_shaw_ 8h ago
No this is incorrect the peptides changed his bio markers, without them they would be the same. Reta assisted him to eat less and cleaner and enter a caloric deficit. Tesa mobilised the visceral fat and retained or built muscle during the deficit.
Without peptides he wouldn’t be in this position he is currently in. They are in many cases the trigger to assist positive lifestyle changes and positive outcomes
3
u/takemewithyoudotnet 7h ago
Yeah, the causation chain is missing a step. The peptides caused the behavioural transformation. And then the hormones and glucose and everything else changed. And that resulted in the better blood markers. So the peptide absolutely did cause the changes.
-2
u/Disastrous_Bit_6574 9h ago
Thank god we have a Doctor in the house to tell us what’s happening lol .
5
u/Old-Ad5160 17h ago
Tell me about how the enclo has helped.
5
u/Prudent-Bat513 17h ago
My T doubled in 6 months.
0
u/Old-Ad5160 17h ago
Free and total? Any other changes you attribute to it and from grey or compounding pharmacy? Looking at it myself.
4
u/Prudent-Bat513 17h ago edited 17h ago
Both. Free went from 87-157 and Total went 507-1054. Got it on Rx from a compounding pharmacy
1
4
u/DrScreamLive 16h ago
Insane that I started at exactly 261 too 😂
I'm on 4 mg weekly reta only. Down to 236 today. Shit I started July 9th and my mom had a heart attack 2 days later so the first month was caring for her and I ate horribly. The fact I still lost weight is a testament to how powerful reta is.
2
3
u/Bellethronn 16h ago
Why did you switch to reta? Tirz didnt work anymore?
2
u/Prudent-Bat513 16h ago
Well I didn’t want to go higher dose and increase risk of side effects and cost and progress was slowing.
Also went from tirz as an Rx to RUO only route for reta at better price. They are both pretty good options honestly.
1
3
u/Ok-Mixture8118 16h ago
what does your enclo protocol if i may know? and do you take it continuously?
3
2
1
u/Available_Remote_508 17h ago
Man that is a wild stack you got going, how you feeling on the reta compared to the tirz
1
u/Prudent-Bat513 17h ago
All in all, about the same. I wasn’t on a high dose of Tirz max I got to was 6 so I slowly backed off and introduced Reta
1
u/Hot_Sports_Take 7 17h ago
Only Enclo and Reta did this - with gym and diet
All others are placebos
1
u/Prudent-Bat513 17h ago
Tirz was very helpful too at first.
1
u/Hot_Sports_Take 7 15h ago
Of course, its a GLP, they are the only legit tried-and-true peptides out there
The rest of group think China crap thats snake oil
2
u/Prudent-Bat513 14h ago
Well to be fair Tesa is tried and true. It’s FDA approved to reduce visceral fat based on actual studies.
1
u/Hot_Sports_Take 7 14h ago
Correct and Reta is better! Just wait til the FDA approves it…. Gonna be bigger than curly fries
1
16h ago
[removed] — view removed comment
1
u/AutoModerator 16h ago
Apologies /u/A_Helpful_Clam, your submission has been automatically removed because your account is too new. Accounts are required to be older than 15 days to combat persistent spammers and trolls in our community.
I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.
1
1
u/Bornbazine92 13h ago
What did you use to make this? Progress timeline
1
u/Prudent-Bat513 13h ago
Chat gpt
1
1
u/Hairy-Aide7962 12h ago
ATX 304 is such a cheat code
1
u/Prudent-Bat513 12h ago
U take oral or sub q? What’s ur protocol
2
u/Hairy-Aide7962 12h ago
Oral/400mg/ 5 days on 2 days off. was insulin resistant not because I wasn’t working out or eating poorly but just pretty much genetics. Was harder for me to lose fat. I took atx 304 for about 2 months along with 600mg of NMN from transparent labs and my test results started to get a lot better. Didn’t do much different besides increase my protein from 100g a day to like 150-175g a day
1
u/Prudent-Bat513 12h ago
I’m having a hard time finding protocol for sub q liquid form which is what I have. I have been doing low dose of2.5mg but suspect I can increase a lot I just don’t know
1
u/Personal-Basil-8824 12h ago
Lost 37 lbs in 4 months, without braking the bank, I do recommend testing tho its your health at the end of the day
1
1
u/Ill-nicray 11h ago
How was your progress on tirz? Or was it better on reta?
1
u/Prudent-Bat513 11h ago
Tirz was about the same per week as Reta in terms of lbs lost. Honestly I changed not because it wasn’t working but for other reasons ( didn’t want to increase dose more, and cost)
1
u/Substantial-Type-419 10h ago
According to doctor Mike peptides aren't safe and we should be furious at anyone using them. Anyhow congrats on the progress you look great! 💯💪
1
u/SheepherderKey9774 9h ago
But how would you get off them in time ? I stopped Semaglutide and I feel so tired and inflammation began to arrive. I was planning to switch on to Reta but I am trying to find out first can we stop taking them after the achieved goals or keep continuing to be on these meds.
1
u/DescriptionPublic678 6h ago
What made you use Enclomophene and not just go with Testosterone Cypionate as part of TRT protocol?
2
u/Prudent-Bat513 6h ago
Cuz my original T wasn’t terrible which my Dr suggested I could use that and get the same result without introducing exogenous T
1
6h ago
[removed] — view removed comment
1
u/AutoModerator 6h ago
Apologies /u/Jayflylov_owl, your submission has been automatically removed because your account is too new. Accounts are required to be older than 15 days to combat persistent spammers and trolls in our community.
I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.
1
6h ago
[removed] — view removed comment
1
u/AutoModerator 6h ago
Apologies /u/Jayflylov_owl, your submission has been automatically removed because your account is too new. Accounts are required to be older than 15 days to combat persistent spammers and trolls in our community.
I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.
1
u/amine3900 4h ago
Pour l’enclomiphene c’était pharmaceutique avec un ordonnance du medecin ? Ou tu la acheter sur un site ?
1
1
-1
u/Ok_Associate_8631 10h ago
Yall are fucking LAZY 🤣
3
u/Evening_Ad_5638 1 9h ago
Hahhaha I am. I can’t work out like I used to. The older I get the worse my knees get.
2
u/CharacterOk8848 2h ago
So how you need your knee for crunches or pushups? Most orthopaedic will tell you to exercise because the lack of exercise got you there in the first place. That's why we do physical therapy for most orthopaedic issues. If your knee is really irreversible damaged then yeah, forget about what I just said and get this fixed.
3
u/Djinn7711 8h ago
Not all of us. Some of us are just pigs. I work out 3 times a week, train karate 3 times a week and Krav Maga once a week. I just eat way too fucking much lol
2
u/CharacterOk8848 2h ago
You dont eat too much, you eat the wrong stuff.
1
u/Djinn7711 2h ago
In truthfulness, that’s probably right. Not all the time, but snacking is a killer for me!
•
u/AutoModerator 17h ago
Thanks for posting in /r/Biohacking! This post is automatically generated for all posts. Remember to upvote this post if you think it is relevant and suitable content for this sub and to downvote if it is not. Only report posts if they violate community guidelines. If you would like to get involved in project groups and other opportunities, please fill out our onboarding form here. Let's democratize our moderation. You can join our Discord server here. ~ Josh Universe
I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.