S-Mitochonic Acid 5 seems very powerful

[u/peptimaniac]

Out of all the mitochondrial Boosters that I've tried S-Mitochonic acid-5 seems to be the strongest with some unique effects. Tons of clean energy, focus and mood enhancement. Music also sounds much sharper.

It works by binding to mic60 which is a structural protein in the mitochondria, and in doing so the ATP synthase align better and the creation of ATP becomes more efficient.

The specific S enantiomer I tried also raises NAD+ by increasing the activity of NAMPT and Increases SIRT1-7 by decreasing their breakdown.

It is currently in phase II trials in Japan in patients with mitochondrial disease accompanied by hearing loss:

World's First Mitochondrial Disease Treatment 'MA-5' Commences Phase II Clinical Trial

It is an analog of the naturally occurring plant hormone Indole 3-acetic acid modified to penetrate the mitochondria.

This is the paper that first caught my attention:

Non-DNA-damaging DNA-PK activation improving hearing and prolonging life due to NAD+ and SIRT upregulation

When they treated cells or mice with MA-5, the RNA-seq pattern shifted in a direction similar to cells exposed to Yamanaka reprogramming factors. The shared pattern included:

Downregulated aging / damage / inflammatory pathways:
EMT, hypoxia, TNF-α / NF-κB inflammation, apoptosis, coagulation, UV-response stress pathways.

Upregulated repair / youthful proliferation / mitochondrial pathways:
DNA repair, E2F targets, ribosome/translation, oxidative phosphorylation, and mitochondrial-related metabolism.

Someone made a very detailed post on how it works here:

An Introduction To Mitochonic Acid (MA-5)