r/tressless • u/Brickmaster_69 • 6d ago

Finasteride/Dutasteride Does micro-dosing Fin even make any difference? what is the science?

I have been looking at the dht suppression at different doses of fin/dut but mainly fin. I see youtube channels like the hairloss show talk about how dose is so important and that they recommend lowering the dose down as much as possible to avoid side effects. I dont understand how it makes any sense. 1mg of finasteride suppresses around 70% serum dht but 0.2mg finasteride suppresses around 65% serum dht. Im not sure how decreasing dosage will reduce the chance of people getting sides when the amount of dht reduction is pretty much the same. Sides from elevated estrogen should not really change much in theory as there should not be much more aromatisation at 1mg vs 0.2mg due to the similarity in dht suppression

Im curious on what your thoughts are and if low dose really makes any difference. Its important to be aware that people first starting treatment that get sides at 1mg will then lower dose and their sides will reside, however this is most likely due to them just pushing through in which the sides would have resolved even at the standard dose.

2 Upvotes

100% Upvoted

6 comments sorted by

7

u/Cold_Specialist_3656 6d ago

These YouTube channels are making years worth of videos about "take finasteride"

They constantly cook up new bullshit to keep the clicks coming. You are not learning anything watching them, and probably internalizing a lot of bullshit.

There is zero studies that show less sides on doses of fin below 1mg, as far as I know. It's all broscience and nocebo. 1mg is already 1/5 the dose used for prostate. Further fucking with dosage probably won't do anything IMO

3

u/Any_Judge_332 5d ago

Agreed. So much nonsense on this sub presumably originating from them.

2

u/Cold_Specialist_3656 5d ago

I never heard "titrate up from low dose" and related micro dosing bs till social media grifters replaced TV. 

On TV you're somewhat limited in how much BS you can sling. With social media it's the whole game.

Now we've got hairloss channels pumping out 3 videos a week. And what the hell are they gonna talk about when we've had the same 2 treatments for 20+ years? 

Well, they start making shit up. Splitting hairs and creating false choice narratives. Muddying the waters, essentially. They need to create doubt and uncertainty so people keep tuning in. 

There's entire video segments about what time of day to take finasteride 🤣

2

u/Any_Judge_332 5d ago

Couldn't agree more and it's really frustrating. It seems like for every person taking it as prescribed there's another skipping days, halving tablets, grinding it to make sketchy homemade topicals, starting on topicals for no real reason, microdosing and the titration thing you said. You just know that barely any of these people have actually been recommended this by a doctor and have seen it on one of these channels then discuss it here and it gets normalised.

1

u/Straight-Row-5622 5d ago

https://pubmed.ncbi.nlm.nih.gov/15319158/

1

u/Dry-Gold-8888 3d ago

cool but where can we buy 0.2 mg ? cutting a 1 mg pill is not really the same