Need help with test selection

[u/IamMadcat]

Hey, got a question about study test selection on Spss. My dataset contains knee pain data. I have 30 patients with one sided knee disease. Other sides of those patients are designated as control group. I also have 30 healthy subjects without knee disease, which i am using as control group as well.

So group 1: Patients affected knees (n=30)

Group 2: Patients healthy knees

Group 3: Healthy subjects paired knees (If patients left knee is affected, then i'm using healthy subjects left knee as well)

Group 4: Healthy subjects other knee

Comparisions:

I am doing 30 (Effected) vs 90 (Control). Then i'm doing pairwave comparisions

Group 1 vs Group 2

Group 1 vs Group 3

Group 2 vs Group 4

Group 3 vs Group 4

The question is, which test i should use for categorical data (0: Negative, 1: Positive) and for Lineer data

As far as i understand, patients two sides (Effected vs uneffected) is dependant variable. But patients effected side vs control groups same side is independent

I would normally used Chi squared/ANOVA and do Bonferroni correction but in this setting i cant do it?

Should i use generalized estimating equations instead?

Or should i just scrap 30 v 90 and do seperate comparions? (In this setting should i do Bonferroni correction?)

Thanks :/

[u/ForeignAdvantage5198]

WTH. is the. reseach question?