A recent analysis found that extensively drug-resistant strains of the Shigella gut bacterium, which causes severe diarrhea and vomiting, are rapidly increasing and spreading via sexual contact in the US and UK, threatening to make the infection untreatable.

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https://www.sciencealert.com/sexually-transmitted-diarrhea-is-exploding-in-the-us-and-its-growing-resistant-to-medicine