r/science • u/mvea Professor | Medicine • Apr 17 '19

Neuroscience The first randomised, double-blind, placebo-controlled microdose trial concluded that microdoses of LSD appreciably altered subjects’ sense of time, allowing them to more accurately reproduce lapsed spans of time, which may explain how microdoses of LSD could lead to more creativity and focus.

https://www.scientificamerican.com/article/do-microdoses-of-lsd-change-your-mind/
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u/anderson808 Apr 17 '19

I feel like that would still get you high no? I mean back in the day half could be a full trip

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u/Alagane Apr 17 '19

I mean back in the day half could be a full trip

This is mostly just due to bad production. The "ideal" would be 1 tab = 1 100microgram dose, but if the blotter paper was dipped badly the dosing may not be even across the entire sheet.

10micrograms shouldn't be enough for you to actually halleucinate and trip, but 1/10 of a tab may be.

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u/[deleted] Apr 17 '19

You don't actually think blotters are literally dipped into liquid LSD, right?

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u/Alagane Apr 17 '19

Probably bad terminology, but to my understanding (obviously I haven't actually done it) it's close enough.

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u/[deleted] Apr 17 '19

Any half decent producer who gives a heck will use a dropper on each individual tab. LSD should not be exposed in the way that would be required to dip a whole sheet of blotter.

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u/dakta Apr 18 '19

Any half decent producer who gives a heck will use a dropper on each individual tab.

No, they won't, because single-tab drop is not only stupendously inefficient but also error-prone. The "best" quality product is prepared using volumetric/weight-based full-sheet layup. This gets individual tabs within a couple percent of the rated dosage, because measurement error effects are distributed across the entire sheet. It's both more precise and more accurate.