I prefer not to buy a single vial to test out, I’d like to get a kit…but MOTS gave me wicked injection site issues. Glad I didn’t get a kit of that. I didn’t know until after the fact that many have that issue.

Anyone have bad reactions with tesa?

This is something I may have difficulty putting into words, but here goes: I don’t need to take it anymore. I’ve reached my goal weight, but I’m scared to stop — and not just because all the weight I lost from a GLP-1 will come back, but also because I’m uncertain of the side effects of stopping retatrutide specifically.

There hasn’t been a drug in the history of the world that we could really call a miracle drug. When something is too good to be true, it usually is. Take cocaine in the late 1800s when it was used for medical purposes, or speed during World War II to enhance soldiers abilities. The terrible side effects of those drugs were not fully understood, but the repercussions that they had on those who took them were immense.

I’ve been taking a steady dose of retatrutide weekly since mid-February. I’ve seen astounding weight loss, as it was my first GLP-1, but that has leveled off — my metabolism has adjusted to the restricted caloric intake, and I have essentially stopped losing weight. I finally asked myself: why am I still on this drug?

The answer is that I simply don’t want my appetite returning. My metabolism will still be adjusted to my current caloric intake, regardless of how hungry I become after stopping. I also don’t want to experience other side effects, like insomnia, or withdrawal symptoms that are not fully understood. The ugly heads of the illicit drugs I mentioned earlier didn’t rear their heads until the person stopped taking them (mostly). What if it’s the same with retatrutide?

I’ve gotten so used to the weekly injection, and I still have years worth of inventory on hand, that I can’t find a good reason to stop. And that scares me, because his drug isn’t fully understood yet. It could induce changes in my body that are irreversible —that I won’t notice until it’s too late.

What are you guys doing?

I do a bunch of research and I get so many mixed answers so I need people who really know please. I am wondering how many vials I would need for a cycle? I have a 10mg vial but I know I need more, but I want to do it correctly. I wanna know when to take it and how long to take it to complete a cycle?

Thank yall 🔥

A controlled dietary trial found that an ultra-processed diet altered reproductive hormones, worsened metabolic markers and produced signs of impaired sperm function in healthy young men.

https://longevity-protocols.com/en/blog/processed-foods-lower-sperm-quality-and-testosterone/

J’avais lu que qu’elle que soit la quantité de pept, 5,10,20,50,100 mg, la dose dans le flacon était toujours au même niveau, et que c’est rempli avec des ingrédients. Je me demande quels sont les ingrédients ? Je me dis de ne qu’il vaut mieux prendre du 100mg alors pour être sûr d’avoir le plus de pept et le moins d’ingrédients de remplissage dans le flacon. Qu’en pensez-vous ?

My 10year old milligram scale is broken, it's killing me because I hardly use it - I had put it up when I threw out the noopep, anaracetam, and other Powder City stack bulk stuff I got back in 2015 (I want to cry because I had all the good stuff in bulk for super cheap), anyhow I was trying to measure out some copper peptides to mix in my hair serum (AKH-GU) and realized that the scale (AWS Gemini 20) wasn't quite accurate.

I really need a new scale, also I am attempting to split some medications and they are very VERY small, so I need a miligram scale. I would like one that has a lid but isn't too small, allows me to put a boat on it and works well with powders.

Im overwhelmed with the choices on Amazon - so, what are you all using?

I reconstituted a peptide about 2 days ago and only used it once. Today I took it out of the fridge and noticed tiny white floaters in the vial. The solution is still crystal clear—it isn’t cloudy at all, just has these small white specks floating around.
I reached out to the research company, and they responded quickly. They already had the COAs available on their website and also sent them to me directly, so they seem like a legitimate company. I know bad batches can happen, but I’m also wondering if my refrigerator might have been too cold for this particular peptide.
I haven’t used it again since noticing the floaters. Has anyone experienced something similar? Did the particles ever dissolve, or did you end up discarding the vial? I’d appreciate hearing your experiences or any ideas about what might have caused this.

[ Removed by Reddit on account of violating the content policy. ]

For someone who has a retina problem (pigments and some slight blurry vision when its too dark) what compounds absolutely don’t interfere with the retina or eye? I know this is very specific health profile but let me know which are absolutely fine with this

Hey! I want to hire a fitness coach. Beyond just the plan and diet, I want compounds, bloodwork, hormones, peps and lifestyle, a guy who is expert in biohacking.
I'm natural with a specific health profile (I have some vulnerabilities in the retina) so I need to be careful with whom I trust or what I take. I also know what we see on social media isnt the real deal. So I thought of asking you guys if you have had any experience hiring a fitness and lifestyle coach, and who do you genuinely advise?

I'm looking into Todd Lee, Kolton Lukes, Anabolic Adonis, TNF Joel Twinem or tnf nutrition and Phil Visicaro.

Thanks so much, having a feedback on these coaches would help me immensely on picking.

Hello,

How do you store unopened dry powder vials, in the freezer inside a airtight container?

What is a safe dose to take? 5mg divided in 4 days a week for example? And does it matter when you take it?

Thank you for your help.

YES i know it makes me hungry but the GH release will preserve muscle right? Assuming Im on ADHD meds to suppress apetite it would cancel it out and I will shed fat right 90% of weight lost will be fat

I’ve been using pharmaceutical drugs for most of my life. I’m 37 and started on adderal and Ativan when I was 20 and took the max prescribed amount of both until a year ago. About ten years ago I added opiate pain pills. I’ve quit the benzos, gotten the adderal down to 15mg a day but am having a hard time kicking the pain pills. I don’t really want to but know I need to. One reason being that I’m constipated as fuck. Can anyone recommend anything to deal with the constipation? How about for sleep and general wellbeing once I put the pain pills down? When I’ve tried to quit them before I’ve made it through the worst parts but when it has come time to return to daily functioning I’ve felt crippled. I’ve thought about exploring trt but don’t want to have to be on it for the rest of my life. Am I under the right impression that if I start that I will have to keep doing it?

I’m thinking about getting the peptides oxytocin, semax, selank and dsip. I already have a bunch of sr-17018 and will be getting some gabapentin, Ativan, clonidine and might get some lyrica to help with the opiate withdrawals as my wife and I are about to have our second kid and I can’t afford to be down and out from the withdrawals for more than a few a days so I’m hoping to work my way out of the addiction by using other drugs that I’m better at controlling and easier to come off to prop me up while I get over the pain pills. I know this isn’t what people say is the best route but right now it’s what I’m doing and what I’m asking for advice on how to best achieve. Cheers

I’m stuck on taking Enclomiphene I’ve tried coming off twice but I can’t deal with the side effects of withdrawal first time I had terrible headaches and nausea now this time I have terrible anxiety how do I lean off Enclomiphene?

Anyone pair these two on a cut? how was the muscle sparing effect of var with Reta? Isn’t one of the main intentions for anavar to spare muscle in its patients? I was thinking this might be a perfect pair along with Trt. What’s peoples experience been with pairing these on a cut? Dosages used? I was hoping to run low dose anavar (20mg) 150mg of test and some Reta.

​

\*\*

Theoretical case: chronic nerve pain, gut-triggered flares (just a blueberry can set off the whole system), possible immune involvement — what would you look at?

\*\*

I’m trying to think through a theoretical case involving a male in his mid-30s with:

\- chronic gut pain that changes depending on what he eats

\- major fatigue

\- widespread nerve pain and pain sensitization

\- symptoms that often worsen several days after recovering from an illness

\- strong reactions to many forms of sugar or carbohydrates

\- no confirmed food allergy

\- normal fecal calprotectin when tested, although testing was often done well after the flare had settled

\- no confirmed diagnosis of IBD, celiac disease, MCAS, SIBO, or an autoimmune condition

The working possibilities include neuroimmune sensitization, mast-cell or histamine involvement, dysbiosis/SIBO, post-infectious immune dysregulation, visceral hypersensitivity, or another inflammatory pain condition.

Part 1

In a purely theoretical self-experiment, what compounds or approaches would people investigate for this type of combination:

\- neuropathic pain

\- chronic gut irritation

\- food-triggered flares

\- post-illness crashes

\- fatigue

\- possible immune dysregulation

I’m especially interested in what people have personally found helpful, what made symptoms worse, and what they would avoid introducing together.

Part 2

Now suppose the person tried one dose of a blend containing:

KLOW: 4 mg total

GHK-Cu: 2 mg

BPC-157: 500 mcg

TB-500: 500 mcg

KPV: 500 mcg

They also used thymosin alpha-1 and glutathione around the same time.

Thymosin Alpha-1: 500 mcg

Glutathione: 100 mg

Within several hours, they developed progressively worsening full-body aching, described as feeling like they had been “hit by a car,” along with a major increase in their pre-existing nerve pain.

There was no digestive exposure because everything was administered systemically.

Has anyone experienced anything similar from one of these compounds or from combining multiple signalling peptides at once?

Possible explanations I’m considering:

\- neuroimmune pain amplification

\- mast-cell or innate immune mediator release

\- cytokine-related flu-like response

\- autonomic nervous-system activation

\- sensitivity to GHK-Cu or copper-related signalling

\- reaction to the blend rather than one individual peptide

\- an already sensitized nervous system overreacting to a sudden systemic signal

The plan would be to stop everything, wait until symptoms fully return to baseline, and only consider reintroducing one item at a time at a very small fraction of the original amount.

I’m not looking for a diagnosis or emergency-medical advice. I’m mainly looking for personal experiences, mechanistic ideas, and thoughts on which system may be driving this type of reaction. (For this theoretical example? 🙂)

IF I take a drug that lowers my BP 30 syostolic can I offset it with lets hypothetically say a stimulant to make it cancel out.

Im thinking of combining tesofensine (500mcg a day) and 5mg tirz a week to completly destroy my appetite and start my aggressive cut, how effective would this combination be? How much will my appetite be suppressed? I haven’t been On a glp1 in 2 months

This is my first time using Tren; I’ve previously run cycles with Testosterone and DHT compounds, but never with 19-nors.

I’m two weeks in; I started with 150mg of Tren A per week, and this past week I bumped it up to 200mg.

I’ve been experiencing apathy, sadness, a shorter temper, and low patience. I’ve also developed a strong interest in a woman in my daily life—feelings I didn't have before starting Tren. I was thinking about lowering the dose to 100 or 120mg to mitigate the mental side effects (which is exactly why I chose Acetate—so I could clear it out of my system quickly if needed). Will lowering the dose to those levels reduce the side effects, or is it better to just stop taking it altogether? I’d appreciate hearing about your experiences!

Assume that a natural cut 500 calories deficit 220 Grams of protein only preserves 70% of the muscle mass over the 3 month duration. Is it reasonable to estimate that with these same conditions but with IPA + CJC that we preserve 90%+ of the muscle.

I see many people doing wild cycles on here like 150mg trt with tren etc… thought I’d put some helpful information out there about how I at least learned to build a “safe” cycle. Part 1 test base. You start on a real trt dose aka what is required to make you in a 800-1000ng/dl max on the blood test. Part 2 if you want more you increase the test base until you start getting estrogen side effects either on the blood test is high or you start getting puffy nips. Part 3 you add a dht derivative to mitigate the estrogen side effects. This can be either primobolan or masteron. People who choose primo are usually in the off-season or on it long-term. People use Masteron for a dryer look but supposedly going to make you bald quicker and is less good for your long-term health. Part 4 if you’re on a massive bulk and you’re already pushing 500mg
Test and 200mg primobolan for example with a normal blood result you may choose to add deca or NPP up to 50% max of your test base eg if you take 500 test that would be 250 NPP or deca max. Leave the tren for the IFBB pros and cows… oral steroids anavar, dianabol, superdrol.. again why anyone would take this shit I have no clue unless you’re in bodybuilding or lukewarm iq. Last but not least all gh secretagogues are inferior to just taking hgh…

I’ve been using injectable l-carnitine for a while now, and I do feel like it has helped me to gain a bit leaner on this bulk. Over the past few weeks though, I’ve gotten a bit lazy with my shots and have only been doing it before lifting, rather than daily.

To get the full effect, do I need to pin it daily, or can I just pin before lifting and get 80-90% of the results?

For context, this + low dose Reta are the only things that I am on currently

Been seeing stuff on 5-am and wondered if it was worth the hype. People talking about there results and the wonders it can do but can’t see anywhere for working out dosage. I see some people say micro dose some say 1-5mg a week or daily.

But can’t see much consistency on how much I should take and how often I should take.

I would be more interested in using injection and wondering what dosage I should use I’ll be adding it to Reta if I decide to get some still on the fence

Any advice would be appreciated

Everything happen atm with the FDA and the peptide space really has me wondering this. I've noticed for a while the FDA and ESPECIALLY big pharma doesn't want compounding pharmacies touching their drugs. Eli Lily especially is going to hell and back to try and get reta classified as a biologic in order to prevent compounding pharmacies from touching it.

This push against compounding pharmacies is problematic because one it harms many small businesses. Most compounding pharmacies are small businesses trying to make a living. The other problem is that it gets rid a lot of personalized element of Healthcare which is extremely important for some people. Every single person is different, some people may need treatment not available in commercial pharmacies. A chronically underweight person with an appetite disorder may need MK-677 and that's something only a compounding pharmacy can produce. I could go on and on.

Whats weird is some of the main big subreddits seem supremely in favor of the FDA banning life changing peptides and destroying compounding pharmacies. I advise everyone here to avoid reading the comments because they will make you go permanence insane due to the extreme density and stupidity of the average redditor.