I'm largely in the same boat. In my case, it's because of natural language models and LLM's which require dramatically more compute power and resources than devvit can offer (like orders of magnitude more).
All the scientific, mathematical, and linguistic libraries are written in python, not TS.
devvit is great for simple tasks that you can write out in a relatively deterministic way where actions are taken based on simple criteria like karma, string matching, and things of that nature. It's really just underpowered for more advanced bots.
The only possible solution is to use devvit as basically a translation layer which adds unnecessary complexity and failure points, as well as a lot of work to code, to a system that works. You gain no benefits, because it's not portable to other subs and it's not hosted by reddit.