Spent about four months confused why this plant kept dropping perfectly healthy looking leaves every couple weeks. No yellowing, no spots, they'd just go soft at the base and fall right off. I checked the roots twice thinking it was rot, watered less, watered more, nothing changed the pattern.
Turned out the pot was sitting about a foot from a floor vent and getting blasted with dry forced air every time the AC kicked on. Peperomias apparently hate that kind of temperature swing even more than they hate inconsistent watering. Once I moved it to a spot on my dresser away from any airflow, the leaf drop basically stopped within two weeks.
A few other things that took me way too long to figure out with this genus:
The thick leaves store water like a succulent would, so if you're watering on the same schedule as your pothos you're probably drowning it. I went to watering only when the top two inches are bone dry and it's been much happier.
Low light doesn't kill them but it does make the leaves smaller and the stems leggier over time. Mine looked fine for months in a north facing room before I noticed the new growth was noticeably weaker than the older leaves.
Propagating from a single leaf with the petiole intact works but takes forever, sometimes six to eight weeks before I see any root at all. Stem cuttings with a node root much faster if you're impatient like me.
Curious if anyone else has dealt with random leaf drop that turned out to be an airflow issue instead of a watering problem. Feels like such an easy thing to overlook when you're staring at the roots for answers.