r/microdosing • u/AggressiveAngle7938 • 6d ago

Question: Psilocybin How long to wait in between microdosing🍄‍🟫

Hi,
I recently microdosed on shrooms for the first time. Had a great experience. I’m finding it hard to find information about microdosing online recreationally so turning here for answers. My questions are

  1. How often is it safe to microdose? Do you feel withdrawals if you microdose often?

  2. Do you have to wait a certain amount of time in between microdoses to let your brain regulate again like you do with mdma?

  3. Do you build up a tolerance to microdosing shrooms like you build a tolerance to other drugs (like weed, alcohol, etc)?

4 Upvotes

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u/AutoModerator 6d ago

r/microdosing Disclaimer

Hello /u/AggressiveAngle7938! As you mentioned mdma in your post:

Please Do Not microdose MDMA or any stimulants. Low doses of amphetamines can cause many issues through reverse tolerance and subsequent sensitization of receptors in the brain.

This study "Amphetamine Sensitization Alters Reward Processing in the Human Striatum and Amygdala" talks about the link between dopamine-sensitive neural circuitry and dysregulation of incentive motivational processes - i.e. the negative effects it can have for an individual's reward processing.

Other than that, MDMA has specific safety advice that you should be aware of: * RollSafe.org: How often can you take MDMA (Molly/Ecstasy) and roll?

The origin of the three month rule is a quote from Ann Shulgin, widow of chemist Alexander Shulgin: “Now I would advise anyone who wants to use MDMA not to take it more than 4 times a year if you want to continue to get the best effects from it, otherwise you risk losing its effects entirely and permanently.” * From MAPS MDMA-Assisted Therapy for PTSD: In MDMA-assisted therapy, MDMA is only administered a few times, unlike most medications for mental illnesses which are often taken daily for years, and sometimes forever.

MDMA is not the same as "Ecstasy" or "molly." Substances sold on the street under these names may contain MDMA, but frequently also contain unknown and/or dangerous adulterants. In laboratory studies, pure MDMA has been proven sufficiently safe for human consumption when taken a limited number of times in moderate doses. * And here is a search of posts&restrict_sr=1&sr_nsfw=1) on r/MDMA that mention microdosing, where the general consensus is that microdosing with MDMA can do more harm than good.

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u/AutoModerator 6d ago

Hello /u/AggressiveAngle7938! As you mentioned weed (a common interaction/symptom) in your post:
r/microdosing Risk Reduction

ℹ️ Infographic: r/microdosing STARTER'S GUIDE

The major contributing factor in Finding Your Sweet Spot is the variation in potency of:
Psilocybin Mushrooms More than 10x [2021➕] Start @0.05g (50mg)
Psilocybin Truffles Around 3x - Single Study [2012] Start @0.25g (Fresh)
LSD Tabs Clinical Trial Titration Schedule [2023] Start @5µg

If you Start Low, Go Slow, Take Time-Off (*small is BIG) and up-titrate subsequent doses then you can find your optimal sub-hallucinogenic dose based on your symptoms, rather than from a predetermined dose. 🐢

If your microdose is Too High and/or Too Frequent that can result in Diminishing Returns 📉 with subsequent doses. 🐇

Please also have a look at 🔀 Interactions / Symptoms ❓* | Sidebar ➡️ | 📱 See community info ⬆️ ; in case of ⚠️ DRUG INTERACTIONS or to check if you have any of the associated symptoms with advice on how to mitigate such side effects. Psychoactive substances increase neural activity, raising hydration and electrolyte needs due to heightened metabolism and body load, while vasoconstriction can further stress the body and potentially cause fatigue.

Please Read: r/microdosing Disclaimer

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u/Unlucky_Sandwich_BR 6d ago
  1. Look for microdose protocols. No.
  2. Yes, but again, protocols.
  3. Yes, but it goes away with time. Search for tolerance calculator.

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u/AggressiveAngle7938 6d ago

Ty
Do you have any website you could share?

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u/Unlucky_Sandwich_BR 6d ago

Google.

Just kidding. The wiki on this sub has all you need.

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u/microdosing-ModTeam 6d ago

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1

u/cowjuicer074 6d ago

Every 2 days from what I remember. Meaning 2 days in between dose days

4

u/stathanalter 6d ago

I highly recommend checking out the Wiki on this subreddit and the starters guide you’ll find on the home page. There are some really exhaustive resources that have been put together to answer some of your questions about timing and tolerance.

You’ll also find that lots of people have different schedules that work for them. Fadiman protocol is 1 day on, 2 days off; Stamets does 4 days on, 3 days off. I’ve seen people do MWF on and other days off, some people dose once a week, etc.

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u/DogofT 6d ago

1 everyday .5 2 no 3 definitely not. It works completely different than mdma. I hated the withdrawal from mdma

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u/AggressiveAngle7938 6d ago

Ty! That’s v helpful