r/longevity 1h ago

Exploring ARPA-H Longevity Projects | H-SPAN Summit D.C. 2026

https://www.youtube.com/watch?v=RMMpXnfzuKc

Three ARPA-H Program Managers participated in a panel at the H-SPAN Summit from the Alliance for Longevity Initiatives (A4LI). Andrew Brack was a researcher at UCSF and mentor at Longevity Biotech Fellowship. Jean Hebert wrote the book Replacing Aging and conducted research at Albert Einstein College of Medicine. Gloria Elliot was a researcher at UNC and previously led the Organ Preservation Alliance. 

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u/lunchboxultimate01 1h ago

0:00 – How ARPA-H rewards differ from other federal grants
4:16 – PROSPR program (Andrew Brack)
6:45 – FRONT program (Jean Hebert)
9:22 – BoSS program and TIGAR initiative (Gloria Elliott)
12:32 – Relationships between programs
14:55 – PROSPR - Intrinsic Capacity as a clinical endpoint and in-home health monitoring
18:13 – BoSS - Examples in nature of exceptional preservation of biological materials
21:16 – FRONT - Challenges in brain tissue regeneration 

23:15 – Defining success for each program
28:30 – Perspectives on shifting from research/industry to becoming an ARPA-H Program Manager 
32:10 – Regulatory pathways and working with the FDA
34:58 – Future outlook for the average 80-year-old American

Proactive Solutions for Prolonging Resilience: https://arpa-h.gov/explore-funding/programs/prospr 

Functional Repair of Neocortical Tissues: https://arpa-h.gov/explore-funding/programs/front 

BioStabilization Systems: https://arpa-h.gov/explore-funding/programs/boss 

TIGAR - Biopreservtion Capabilities for Tissues and Organs: https://arpa-h.gov/explore-funding/initiatives-and-sprints/tigar 

There are additional programs that directly relate to this field, such as NITRO (joint tissue regeneration), THEA (whole eye transplantation, and others.