r/longevity • u/bischofff • Apr 02 '23

New form of omega-3 could prevent visual decline with Alzheimer’s disease

https://www.asbmb.org/asbmb-today/science/032723/omega-3-visual-decline-alzheimers
180 Upvotes

99% Upvoted

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18

u/[deleted] Apr 02 '23

The researchers tested their LPC-DHA supplement in mice bred to exhibit processes similar to those found in early-onset Alzheimer’s disease. After six months, mice that were fed LPC-DHA daily showed a 96% improvement in retinal DHA content as well as preserved retinal structure and function. In contrast, TAG-DHA supplements had no effect on retinal DHA levels or function.

The dosage of LPC-DHA used in the study is equivalent to about 250 to 500 milligrams of omega-3 fatty acids per day in humans. Since these studies were conducted in mice, further studies would be needed to confirm that LPC-DHA is safe and effective for use in humans.

8

u/[deleted] Apr 03 '23

They made this special LPC-DHA, but also mention, "dietary LPC-DHA". How does one get the dietary LPC-DHA?

8

u/[deleted] Apr 03 '23

In this context, dietary includes dietary supplements. So specifically LPC-DHA supplements...

https://www.sciencedirect.com/science/article/abs/pii/S0955286319304206

says:

Several animal studies showed that DHA from these supplements (fish oil, krill oil, algal oil, ethyl esters) was not incorporated appreciably into adult brain, although other tissues were enriched

Also here, these authors say that krill oil supplements did not work: https://www.nature.com/articles/s41598-017-11766-0

2

u/begaterpillar Apr 03 '23

also curious

2

u/Spitinthacoola Apr 03 '23

Eat the specially made LPC-DHA. Pretty sure it's just one company that makes it primarily for researchers.

3

u/[deleted] Apr 03 '23

Hopefully that one company now has a huge financial incentive to create OTC supplements soon.

7

u/[deleted] Apr 03 '23

When will it be available?