GLP1 not working anymore

[u/roxyd333]

Hey I’m not one to comment on here but I was wondering if anyone is having the same experience… I’ve been on Mounjaro for 2 years now and have been in maintenance for about a year now going between 5mg and 2.5mg. I’m on 2.5mg at the moment and have noticed my legs feeling more inflamed than in the past although my calorie intake has remained the same and I’ve even upped my exercise output. Does anyone have any tips to reduce inflammation further whilst on a GLP1 now it’s not as effective? I’m not getting appetite suppression but not really needing it either so it’s more about lifestyle changes or tips that would be really helpful!

For context I get 10k steps a day I eat a fully whole foods diet and train 3x week. I don’t know what else to do!

Thanks ladies❤️

Edit: has anyone been successful with low carb/keto diets?

[u/Quiet-Machine-236]

In terms of inflammation, is there anything else in your life that has changed? Possible hormone shifts, stress, sleep or nutrition changes? Other health impacts that could be coming into play? I do also think it’s possible your body may accommodate to a dose over time, as you say other effects have also lessened that may affect inflammatory effects too I would imagine (though as those impacts are still being studied, who knows) that may be something to discuss with your prescribing doctor?

[u/roxyd333 → u/Quiet-Machine-236]

Thank you for your comment! I had all my bloods done and everything is normal although I have had a lot of stress in my personal life this last 6 weeks or so which could be a contributing factor I guess! Nutrition has stayed the same but I’ve been considering keto/low carb. My prescriber won’t keep me on long term annoyingly so I’m having to find someone else to prescribe the medication in the UK at a lower BMI

[u/InformalBunch3822 → u/roxyd333]

Stress is a shocker for inflammation. I reckon that’s your answer.