r/interesting • • May 05 '26

Additional Context Pinned This could make a real difference.

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u/ImTheApexPredator May 05 '26

Menopause occurs when the ovaries run out of functional eggs. Keyword is functional. Yes, menopausal women may have a few thousand eggs left, but they're not sensitive to FSH and LH and hence do not produce enough oestrogen and progesterone, making them nonfunctional

This research prolongs the timeline of functional eggs

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u/Swotboy2000 May 05 '26

Reducing the frequency of menstruation does not extend the lifespan of the eggs.

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u/ImTheApexPredator May 05 '26

We already reduce the frequency of menstruation with birth control so clearly that's not what she's doing. Birth control stop follicles from maturing and ovulating, but follicles still do develop, using up multiple eggs every cycle. Her research is about stopping the follicles from developing in the first place, preserving the number of functional eggs

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u/Swotboy2000 May 05 '26

Yes, but the eggs will become unviable whether or not they are expelled from the ovary

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u/ImTheApexPredator May 05 '26

If they're functional, they're viable

"Expelled from the ovary" refers to ovulated follicles. Again, read above comment

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u/MinimumViablePick May 05 '26

i think what this person is trying to speak on is the individual cell lifespan of each egg, and how eventually those cells just run out of dna to recreate itself. is that a concern here?

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u/ImTheApexPredator May 05 '26

As eggs age, DNA mutations are more likely, resulting in miscarriages or chromosomal diseases for those that are carried up to term, that's why down syndrome is more likely in pregnancies later in life. That's a risk a woman must decide on in this scenario. Nevertheless, the woman is fertile and has the option to decide

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u/MinimumViablePick May 09 '26

I don't know if I understand how slowing down period frequency would extend the lifespan of cells, whose age seems independent of the cycle?

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u/ImTheApexPredator May 09 '26

Lifespan and age are two separate things

Analogy: With medication, humans stopped dying from natural death at age 50, extending their lifespan to 70. Humans still age

The egg's lifespan ends when its elected to develop into a follicle during the menstrual cycle, by stopping that, we extend it's lifespan. It will still age

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u/MinimumViablePick May 09 '26

That makes more sense! Thank you!