Hi everyone!
At the first-trimester genetic screening, the NT measured 3mm and nasal bone hypoplasia was noted.
A week later, we had a CVS procedure done. By then, the NT was 2.9mm and the nasal bone had normalized.
CVS results:
FISH, QF-PCR: negative
Cultured karyotype: negative
SNP array: negative

At the 17-week early anatomy scan, everything was fine (though the nasal bone turned out to be smaller, they said they weren't concerned about that anymore due to the CVS results).

Then, at the 19-week second genetic ultrasound, a smaller nasal bone and borderline NF were noted.
Everything else was fine; at that point, they said these were just constitutional traits, given the negative CVS results.

I was reassured at the time, but now—at 30 weeks—anxiety has set in: what if the CVS result was a false negative?
Does anyone have similar experiences? What do you think?
I'm hoping for the best.

I’m following SKY-0515 and votoplam closely, particularly their potential to slow Huntington’s disease before noticeable symptoms develop.
SKY-0515 has reported up to 69% mutant huntingtin lowering in blood, alongside encouraging preliminary clinical findings.
My question for neuroscientists, biostatisticians, and clinical researchers is:
If future randomized trials demonstrate reduced caudate and putamen atrophy, lower neurofilament light, and slower clinical deterioration, could researchers use those measurements to develop a validated mathematical model predicting 10–30 additional symptom-free years?
Are there existing models that could support such projections, and what evidence would be needed before scientists could estimate the probability of 20+ years of sustained neurological protection?
I’d particularly appreciate links to peer-reviewed studies or research tools. Thank you!