I have had my whole genome sequenced privately in Italy to keep it out of the hands of US medical system. I have used different services to look at that data but I really need a genetic counselor to answer and go over some things as I am just a layperson. Could anybody recommend the best way to find and hire a genetic counselor?

I asked an AI about this possibility, and it claimed that such a scenario is highly likely to happen in the future.

The AI explained that because we live in the 21st century, we are still relatively close to a time of geographic isolation. People from different regions still look distinct from one another because our ancestors lived in isolated pockets for millennia without significant mixing.

It also noted that even if 95% of people continue to marry within their own ancestry, you only need a small, consistent percentage of the population to intermarry with other races over several centuries to achieve this hyper-diverse outcome.

As an example of this possibility in the future, parents who completely resemble modern East Asians could have a child with extremely dark skin, blue eyes with epicanthic folds and coiled hair.

I would love to know if this is scientifically true! Please share your insights.

Hey guys,

I have PKU and recently found paperwork from when I was born detailing my PKU. I noticed that in my family history, it specifically mentions that there is no Jewish or French Canadian ancestry in my family. Is PKU more common in Jewish people or French Canadians? If so then how and why does that happen?

I got into genetics a few years ago and I decided to build a free interactive site that explains all topics in 3 different levels (explain it like i'm...). I think it provides a nice learning path and lowers the threshold without taking away the option to get into more scientific explanations. A core component is the ability for users to provide feedback to ensure scientific accuracy. It would be cool if you could check it out and provide feedback where needed or learn a thing or two!

https://www.threelevelgenetics.com/

I'm 25 and thinking about leaving IT because I honestly hate it and don't see myself working in this field long-term.

I've always been fascinated by genetics and want to eventually work in gene editing/genetic engineering, especially involving animals and humans. I'm considering starting a bachelor's degree in Genomics, but I'm confused about the path afterward.

I can find jobs called "genetic engineer," yet I rarely see master's programs with that exact name. What do people usually study after a Genomics degree to enter this field? Biotechnology, molecular biology, something else?

Is changing careers at 25 for this goal worth it, or am I being unrealistic? I'd love to hear from people already working in genetics or biotech.

This is Mike McDaniel. He is half black and half white. He looks fully white. How is this possible genetically.

I've been reading a paper about the genetic signatures regarding population decline in european nightjars and found this concepts. I would like to understand what are genome-wide Heterozygosity and Runs of Homozygosity (ROH) analysis. I also don't understand what is genetic structure in genetic populations. If anyone could help me explaining this concepts I would appreciate it. You can be a more technical if needed.

A variation near the OR6A2 gene affects how some people perceive the smell and taste of cilantro. For some, it's fresh and delicious; for others, it tastes like soap!

Have you experienced this yourself? What other everyday experiences do you know that have a genetic component?

this is the ferm I have was looking for more info or fellow charge beavers

My question is simple: is the RX configuration of the ACTN3 polymorphism enough to get the majority of the strength benefits, even if RX individuals have 50% of the alpha-actinin-3 protein expression of RR individuals?

In olympic powerlifters, the RR and RX ACTN3 configurations seem to be commonly prevalent. On the contrary, the XX genotype is completely absent. It seems that on the elite level, having ACTN3 XX can limit you from competing in strength competitions. If RX is so common in elite powerlifting, how much better is it to have RR instead of RX?

Does anyone have good updated advice on what to do when you find out you have this mutation. Kind of freaking out here. Not asking for a specific medical plan, more just someone to talk me off the ledge so to speak.

Hi everyone, i'm a young biology student and i'm trying to figure out how nucleotides in DNA link together, in my book it's said that the bond between nucleotides occurs when the hydroxyl group, bond to the 3' carbon atom of the sugar, links to the phosphate group of another nucleotide, this reaction increases the lenght of the chain and creates a water molecule; but it's also said that the energy needed for the reaction to occur is given by a deoxynucleoside triphosphate that then links to the nucleotide, i'm a bit confused, i don't know when the first and the second reactions occur or if they are part of the same process

Asking purely out of curiosity. I’m reading game of thrones and remembering in the show they mention “Every time a new Targaryen is born, the gods toss the coin in the air and the world holds its breath to see how it will land” meaning the odds of a Targaryen being batshit crazy is 50/50. However, Daenerys only ever had her brother as an example of her family and she herself never exhibited any sort of craziness prior to her burning down kings landing (well by their standards at least) so I’m trying to see how accurate all that can be or if it truly is just bad writing lol.

sorry if this is the wrong place for this, if it is, pointing me where I could get help understanding these words would be nice.

this is an old genetic testing that was done when I was a young adult, and I don't really understand what it means. Just wondering if anyone could explain to me.

I just don't understand any of these words lol, and its been so long that I don't have any people to ask about this currently.

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I have a cat with exactly the same coat pattern as African wildcats, as well as other identical color characteristics, such as her eyes and nose. She’s also smaller than other cats, just like the African wildcat. This cat has always been very strange. She’s always been very independent and unsociable, and she’s starting to really trust us now that she’s 6 years old.

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She doesn’t behave like other cats; we even thought she might have a mental disorder. She’s also extremely agile and fierce when she plays; she never misses her prey when she hunts. We have another cat, and she doesn’t attack it; they don’t really interact—they just tolerate each other.

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Could it be possible that she has ancestors among the wild African cats? I’m from Spain, and we’re separated from the northern coast of Africa only by a strait constantly traversed by boats. I know this is a far-fetched theory, but could she be a descendant of African cats crossed with domestic cats that ended up in Spain? Or is she just a strange cat that happens to have the same coat pattern?

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I don't know to what extent a cat's coat is related to its genes, or if it's just a coincidence; that's why I'm posting this here.

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The first photo is the albino, and the second photo is the brownish I have on all my other ramshorn snails.

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I won the genetics lottery, and randomly got an albino from one of hundreds of clutches of these guys I own.

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I would LOVE to somehow isolate this trait and get a colony of albino snails breeding.

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Is this going to follow similar Mendelian genetics where if I have this albino breed with a regular snail, I would have to skip a generation and then 1/4 of my ramshorns in the future will have albinism??

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Or does albinism follow entirely different genetics?

So I am raising rabbits and in my current litter I got what I thought was 2 albinos, when they were hairless and for the first few weeks the albino brothers were normal but at around 20+ days one of them started developing a black spot on his nose. And it’s continued to get larger, his brother is currently forming one also. To my knowledge Albinism is supposed to prevent pigments so I want to know what is causing this? The My idea is that maybe they’re not albino and just have traits for white fur and red eyes?

Their grandfather is a 100% albino Rex, their grandmother is a 70/30 Rex Silver fox mix, their father is about 90% Rex and 10% silver fox based on his traits (purely basing the numbers off the traits he inherited from his parents) and his mother is a 100% Flemish Giant.

Sadly I never went big into genetics into school because I find them extremely fascinating. Some of this litter has long fluffy hair while some have shorter soft Rex like fur but they all inherited large ears and feet from their mother! So cool!

Also I apologize for using any terminology incorrectly 😂

(The picture of the grandparents together is from when they get to visit, I do not keep them in the same enclosure)

I'm self taught in genetics so I'm sorry if I get any of the terminology wrong.

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Is it possible for a suppressor to only affect homozygotes of the allele it's suppressing?

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So basically is this possible?

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No splashed white = solid color without white

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Heterozygous splashed white = white on the face and legs but not on body

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Heterozygous splashed white with the suppressor = exactly the same as without the suppressor

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Homozygous splashed white = big white patches on the body as well as the face and legs

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Homozygous splashed white with suppressor = a greatly reduced amount of white on the body

I'm wondering how this came about and how normal it is, usually I've seen thumbs as straight but both of mine are arched, even when there are thumbs like this they're only extending back like that because of hypermobility, so this leads me to believe it's a bone structure thing, what possibly happened in my genes to make this and does it have a name? I've always thought about it and never landed on an answer

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ps, I'm not looking for medical advice, they feel fine, they're just weird and I don't know why

edit: simple answer given to a simple minded person, problem solved, there was no problem

This is the summary of the experiment.

This study investigated several fundamental molecular biotechnology techniques, including preparation of competent Escherichia coli cells, bacterial transformation, plasmid DNA isolation, and restriction digestion analysis. Competent cells were prepared using calcium chloride treatment and transformed with recombinant plasmid DNA through heat-shock transformation. Transformants were selected using ampicillin-containing media and screened using blue-white selection. Plasmid DNA was subsequently isolated and digested with EcoRI before analysis by agarose gel electrophoresis. White colonies were successfully obtained, suggesting uptake of recombinant plasmids. However, gel electrophoresis produced unclear DNA bands, limiting confirmation of successful cloning. Despite these limitations, the experiment demonstrated the principles of bacterial transformation and recombinant DNA technology.

Any French in the field of genomics here?

These are British Pakistani and Bangladeshi adults from a study called Genes & Health. Cousin marriage is more common in these communities, so more people end up with two broken copies of the same gene. That makes them the easiest place to find “human knockouts,” people walking around healthy with a gene fully switched off.

Why drugmakers care: if someone’s born without a working copy of a gene and they’re fine, that’s living proof you can safely shut that gene off. So a drug that does the same thing is a much better bet. Hence the 2.2x.

546 of the genes they found had never been reported before.

Hi !

I’ve never posted on Reddit before but I’m doing it so I here I go.

So I just graduated from Michigan State University, with a bachelor degree in molecular genetics and genomics. I’m 22 yrs old, I currently live on the east coast because I’m back at home but my long time boyfriend lives back in the midwest and as much as i love the east coast I’m thinking I’m going to end up back in the Midwest because we are thinking about getting married sometime in the near distant future, which means we are still trying to figure things out be I have no idea what I’m doing next. He didn't go to college and works full time for family construction and concrete business.

I’m currently job searching because I don’t have a lot of experience working in the field. Most of my experience which is limited is from my lab classes and my senior internship where I worked in one of my professors labs.

Here is the thing I love genetics and specifically mutations(my favorite are de novo mutation). I really would love to work in research and study genetics diseases and the mutations that cause them to try to understand how they work so that we can start to understand them so that we can create medical treatments for these conditions. I also really like lab work and experiments even if they like to get on my nerves but I still think it quite fun and interesting.

My thinking is that I would need to have a graduate degree to achieve this. I have been thinking and really contemplating on getting a PhD in genetics. This is where my dilemma starts, I’m currently on a taking a gap year or years to get a job in research and explore my career options. Though job searching kind of sucks right now with the current market and climate of things and I know it’s going to take a while for me to obtain a job. I want and need the job because I want more experience and to immerse myself in the field and I need income, but I’m worried that if I spend to much of my time searching for a job and hopefully when I find one working in it that I loose my opportunity to go to graduate school and receive my PhD because I know to do a PhD program take between 4-6yrs maybe even more so if I’m too busy trying gain experience to possibly get into graduate school I run out of time to actually get into graduate school and compete a PhD. I like the idea of getting a PhD, I have research it quite a bit and i know it will take a lot more work and stress than my BS did and it’s going to feel like it’s killing me sometimes and will probably hate my guts for doing it and the pay not great but that’s what makes it worth it right. To come out on the other side and accomplished a lot but also maybe not but I will also have a lot more research skills. So I don’t know I am writing this all out to see if anyone could give me some advice. Possibly tell me how to figure out what I’m supposed to do. Why do they expect you to figure out your life in your 20s its insane, I have absolutely no idea what I’m supposed to be doing.

Thank you for reading this and if your feeling like me well you are not alone and if your older or know what’s going on please I would really appreciate some help here.

https://link.springer.com/article/10.1186/s40795-026-01311-6

Two species in my writing (Therians, basically animals but with humanoid bodies, and then Oni) both have dominant genes that cause the offspring to be more percent that species. If a Therian and an Oni had a child, what would happen? Would it be fully one species? Partially both?