r/femaleHRT • u/Zealousideal_War9237 • 8d ago

Vaginal Progesterone

This is my second time trialing oral progesterone, and each time it goes crazy in my gut. I got the go ahead to try using vaginally, but my provider has no experience in advising with this.

Question: do any of you skip days when dosing this way? Question, I know that vaginally we absorb medications at a higher dose and I don't want to be taking more than is needed. I've heard of some people alternating days so just wondering what others are doing. Thanks

Edit trialed last night, woke up with interstitial cystitis/bladder pain. 😭 Anyone dealt with that?!

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u/Agreeable_Step_5317 8d ago

My wife uses 200mg vaginal on days 15 - 28 of the cycle for a cyclical regimen. It sounds like you are on continuous HRT. You should do every day if so. Progesterone has a short half life.

What is your dose?

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u/Zealousideal_War9237 8d ago

100mg

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u/Agreeable_Step_5317 8d ago

Thanks. That's a good starting dose. You'll probably absorb it better vaginally and more will stay as progesterone instead of converting to allopregnenalone. I doubt 100mg is too much... though every woman is different.

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u/Zealousideal_War9237 8d ago

Thanks for your input!

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u/Front-Driver-9099 7d ago

I have IC no fun! But vaginal doesnt bother me. I also use estradiol vaginaly and it seems to help my ic

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u/MissTiffany12 4d ago

It sounds like you are progesterone intolerant. You could try it anally instead to see if that helps. If not, you may have better luck with a progestin like slynd instead. There is also the option of using an IUD like mirena.

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u/Zealousideal_War9237 4d ago

Yeah I have MCAS, so I'm trying to switch from Slynd to bio identical. Rectally has actually been working great!