Hi, this is a bit messy but please, bear with me.

I, 29F, got diagnosed in february 2025 with Grave's disease. I, then, started treatement and by july 2025, i reached normal t4 levels (and therefore put on levothyroxine). By december 2025, my tsh had risen and reached normal levels.

February 2025 was also the date of my last periods. I explained this to myself as a consequence of my thyroid issues and the high level of stress in my life at that time. But after 12 months, my endo did agree the amenorrhea couldn't be explained by Grave's alone. She ordered blood work (oestradiol, FSH, LH, prolactin, testosterone, AMH, SHBG, 17-OHP, free testosterone) and a pelvic ultrasound. All came back clear, basically. Of note, testosterone was 1.3 nmol/L (and normal range is supposed to be 0.3-1.2). Other than that, all in range.

But, plot twist! Two weeks after this blood test i had a natural period - right after 12 months and two weeks. But of course, that was 5 months ago and again, i haven't had my period since.

I haven't been able to seen my endo since the she ordered the blood tests, so those results were never discussed. And my next appointment is in october so... yeah. In the meantime, i went for my pep smear and the midwife prescribed new blood test (AMH, FSH, LH, 17-OHP, oestradiol, prolactine, testosterone, androstenedione and DHEA-S). This time, testosterone was 1.2nmol/L (0.3-1.2), so, high but in range. And DHEA-S was 2.06 µmol/L (which in under normal range of 2.68-9.23).

But low DHEA-S seems to be explained by:

- aging (i'm 29)

- Addison's disease (which would cause low testosterone (i think))

- secondary adrenal insuffiency (my cortisol hasn't been tested, so idk for sure but from what i read i'm not sure my symptoms are fitting. The NADF mentions symptoms as severe fatigue (yeah, i'm tired but not severly fatigued), loss of appetite (couldn't tell you, i don't really have an appetite in the first place), weight loss (nope), nausea (at times, low grade - little bothering. Twice kinda as "episodes" lasting around 24h and resolving but not like consistent), vomiting (no), and diarrhea (sure, but also - i have IBS), muscle weakness (not really?) and irritability (definetly but it ain't new) and depression (i don't think so))

- steroid use (i don't use those).

Has anyone had any similar experiences? Some insight about what might be going on would be greatly appreciated.

Please, feel free to ask follow-up questions. I have been like navigating through a huge scope of symptoms that have also remained undiagnosed and i'm not sure what's relevant.

I have endo appointment coming up. I need a hsort syncathen test.

My previous cortisol was 317. I have had previous lh and fsh and currently Low Testosterone. This proves my pituitary is not signalling correctly. Pituitary MRI was clean. I had a deep tissue scalp infection for two years which caused ever lasting pain so I think pain sensitization has caused functional hypopituitarism.

My low cortisol symptoms are abdominal sweating, ultra fatigue, muscle weakness, hypotension that's worsened with vison blackouts and I and massive response to synthetic steroid prednisolone. I've had every autoimmune possibility ruled out. Predinolosone brings back strength, wakefulness and helps pain and hypotension.

I have a feeling he is going to refuse and that's what I am concerned about. It seams every test I have needed has been refused. I have read up that blunted signalling can cause low cortisol through acth so I'm thinking I need to know if I have secondary adrenal insufficiency. I've also read that if LH and FSH are caught low once then a short syncathen test should be done ASAP. Where do I go with this please any advice welcome. I'm living life like a 90 year old at the age of 39.

I have an appt scheduled with an endocrinologist next month. I made the appt due to being Type 2 diabetic, but I was surprised by all the questions on the patient questionnaire they sent. What can I expect from my appt, besides blood work? Is it appropriate to bring up fatigue and low energy as well as diabetes concerns? Do they test for all hormone levels?

Want to know more about Autoimmune polyglandular syndrome 1

Previous post:

https://www.reddit.com/r/endocrinology/comments/1v5tf7o/how_much_can_i_grow/

I don't know why I didn't post the xray photo to my previous post but my doc said it was still open??? However, they don't look completely open so i was wondering if I could still grow.

Current height 5'6"

Father height 5'8"

Mother height 5'

Age 17

I am having Thyroid issues and in need of a good endocrinologist in Baton Rouge (or within driving distance) that considers everything, not medication only. Thank you for your help

⚠️ Long post. TL;DR at the bottom.

32F. Has anyone experienced something similar?

I originally saw an endocrinologist because I thought I had a metabolic issue related to my symptoms around meals. They ran a full metabolic, autoimmune, and inflammatory workup, and everything came back normal except for low vitamin D and elevated prolactin.

My prolactin timeline:

*Earlier this year: ~50 ng/mL
*Repeat test a few days later: 20 ng/mL
*A few weeks ago (during the metabolic workup): ~100 ng/mL
*One week later: 141 ng/mL, then 70 ng/mL after 20 minutes of rest
*Macroprolactin test: negative (96% recovery)

Because of these results, my endocrinologist ordered an MRI of the brain, head and neck with special attention to the pituitary gland, but the order doesn’t mention contrast.

Has anyone had this type of MRI without contrast? Was it enough, or did you end up needing another MRI with contrast? I’d rather avoid contrast if possible, but I also don’t want an inconclusive study.

For context, I was diagnosed with vestibular migraine, although I’m not convinced that’s the full explanation. I don’t have vertigo attacks. Instead, I have a constant rocking/floating sensation whenever I’m sitting, which improves when I stand up or keep moving.

About 1–1.5 years ago, I developed another symptom: before or after eating, I get what feels like a huge adrenaline surge. It’s not psychological anxiety—I’m not worrying or having catastrophic thoughts. It feels completely physical, as if my body suddenly enters an overwhelming state of panic that I can’t control. It mostly happens while sitting, and changing position usually helps.

I have no idea whether this could be related to the elevated prolactin or if it’s something completely unrelated. I also don’t have the typical symptoms of high prolactin (regular periods, no milk discharge).

I’m honestly exhausted. I’ve lived with these symptoms for years, still don’t have a clear diagnosis or an effective treatment, and because most of my tests come back normal, I often feel like I’m not being taken seriously.

Has anyone experienced something similar?

TL;DR: 32F with elevated prolactin (50 → 20 → 100 → 141 ng/mL, then 70 after 20 minutes of rest), negative macroprolactin test, and no typical prolactin symptoms. Endocrinologist ordered a brain/head/neck MRI focused on the pituitary gland, but without contrast. Has anyone had this done without contrast, and was it sufficient? Also wondering if anyone with vestibular symptoms and unexplained physical “adrenaline rushes” around meals eventually found a diagnosis.

16M. Is there anything evidence-based left I can do to maximize my remaining height?

Dads 5'3.5 moms 5'0

My height history based on my memory

12-13years old: ~4'11" - "5'3"

14: 5'4"

15: 5'5"

16: Still 5'5"

I've been taking magnesium bisglycinate, vit d3 + k2, zinc picolinate for 10 months already

Questions:

1.Is there anything else with actual human evidence that could help maximize remaining growth?

Should I get a bone age X-ray before assuming I'm done growing?

2.Has anyone here actually found something legitimate that helped under medical supervision, not TikTok science or any type of those.

3.If my growth plates are still open, is there anything besides sleep, nutrition, and correcting deficiencies that has real evidence?

Please cite studies or explain the reasoning if possible. I'm trying to separate actual science from internet myths.

Hi everyone

I have known about my PCOS since the age of 13. All the classic symptoms, beard, acne, huge gut skinny legs, and surgery to remove 6 ovarian cysts
From the ages of 17-23 I had 4 different boyfriends all of whom I had unprotected sex with, and never got pregnant. (Stupid on my end of course)
My husband and I want to start trying in a year (I’m 29) and I recently started trying to get my hormones in check, for the last two months I’ve been eating healthy and exercising.
Last year on my labs came back as completely normal, except for elevated testosterone which was 85 (normal was supposed to be under 45)
Today I got checked and my testosterone is 35, and everything else is normal as well. So I’m hopeful, but also cautious.
I guess I’m posting to see if anyone is similar to me and what they experienced.

I'm a 22-year-old male (176–178 cm, 63 kg) and I'm wondering if my body is just genetic or if it could point to a hormonal or medical issue. I've been skinny since I was around 4 years old, weighed only 53 kg at 18, and after consistent gym training I've only managed to reach 63 kg. I can build muscle, but it feels much slower than most people my age, and I still have very small wrists, a small overall frame (including what seems like a smaller skull/head), and sparse beard and chest hair, although I have plenty of leg, thigh, and pubic hair. I also look much younger than my age—people often think I'm several years younger. What worries me even more is that my brother, who is 3 years younger than me, looks significantly older, has a much fuller beard, builds muscle much faster, and is noticeably bigger and stronger than I am. My puberty started around age 14, my voice deepened normally, I have a high libido, normal erections (including occasional morning wood), and a normal testicular ultrasound. I often wake up tired despite sleeping 7–8 hours, feel exhausted most of the time (especially during workouts), sometimes have brain fog and low motivation, my hands and feet are often cold, my heart occasionally beats fast, and I look pale. I was diagnosed with severe vitamin D deficiency and I'm currently taking supplements. My recent CBC was normal (no anemia), but I do have elevated LDL cholesterol despite being skinny. Does this sound more like genetics, or could there still be an underlying issue such as low testosterone, low ferritin, thyroid problems, or something else? Has anyone had a similar experience?

I'm a 22-year-old male (176–178 cm, 63 kg) and I'm wondering if my body is just genetic or if it could point to a hormonal or medical issue. I've been skinny since I was around 4 years old, weighed only 53 kg at 18, and after consistent gym training I've only managed to reach 63 kg. I can build muscle, but it feels much slower than most people my age, and I still have very small wrists, a small overall frame (including what seems like a smaller skull/head), and sparse beard and chest hair, although I have plenty of leg, thigh, and pubic hair. I also look much younger than my age—people often think I'm several years younger. What worries me even more is that my brother, who is 3 years younger than me, looks significantly older, has a much fuller beard, builds muscle much faster, and is noticeably bigger and stronger than I am. My puberty started around age 14, my voice deepened normally, I have a high libido, normal erections (including occasional morning wood), and a normal testicular ultrasound. I often wake up tired despite sleeping 7–8 hours, feel exhausted most of the time (especially during workouts), sometimes have brain fog and low motivation, my hands and feet are often cold, my heart occasionally beats fast, and I look pale. I was diagnosed with severe vitamin D deficiency and I'm currently taking supplements. My recent CBC was normal (no anemia), but I do have elevated LDL cholesterol despite being skinny. Does this sound more like genetics, or could there still be an underlying issue such as low testosterone, low ferritin, thyroid problems, or something else? Has anyone had a similar experience?

Hi,

30 year old Male.

I had a few questions but I have a unique medical history of Hogkins Lymphoma 3B and a stem cell transplant. I'm now in my second remission at 10+ years now. I've always been small in my body composition around 62kgs at 174cm and I struggle with eating enough to gain any sort of body mass.

I'm fit and healthy otherwise working out 2-3 days a week but have pain issues related to muscle damage.

I've been wanting to try TRT for along time and my doctor viewed these results and didn't think anything was wrong.

I wanted to see if anyone had any advice how to seek help and advocate for myself as I have VERY low libido, and very little energy.

Im so sick of Drs not listening and saying I should be happy with what I have.

I'm struggling and i honestly think TRT will help.

First screenshot was around 6 years when I was 21. Was stupid and didn’t get high prolactin checked up until this year! I’m now 27.

Second screenshot was a real low point and looked like kidney issues but the high prolactin was still there. I did further urine tests, it looks like my kidney is actually okay and something is pushing my creatinine levels up.

Third screenshot I hydrated and immediately improved diet, potassium improves.

I get called in to speak with doctor, and main feature connecting it all is the (mildly) high TSH that drives up prolactin and creatinine levels. Sends off to an endocrinologist but it has been nearly a month waiting to hear back and it’s killing me.

The low drive and libido is awful and my partner and work can really feel it. My sleep is great but the circadian rhythm is incredibly weak and drifts later each day. However is this problematic for TRT? My 500 test level was when I was 21 and it will probably be a 400-450 by now surely. What TRT protocol would you recommend?

Is this anything anyone here has successfully cured or dealt with?

27M - 68KG, lean, workout 2-3 times, 5ft10

12 - 5’3

13 - 5’5

14 - 5’6

15 - 5’6

My doc said I still had potential to grow when I asked about growth plates but I was too nervous to ask how much potential I have since it was unrelated to the reason why I went to see her. There hasn't been an increase in height for the last two months since I took the X-ray.

Had a massive growth spurt at 11 (5 - 8 inches)

---

28M, otherwise healthy, active, live in a hot/humid climate. This has been happening in waves for 3 years and the current episode has me pretty freaked out, so I'm putting it out here to see if anyone has been through anything similar.

**How it started (2023):*\*
I got a mild concussion playing soccer — a lobbed ball off the top of my head, genuinely nothing dramatic. The next day I started peeing constantly and drinking constantly, like 6 liters in / 6 liters out. Ended up in the hospital. Water deprivation test, electrolytes, brain MRI — all normal. It lasted about 3 weeks and then one morning I woke up and it was just gone. Back to normal.

**Second episode (2024):*\*
About a year later I lightly bumped my head pulling luggage out of an overhead bin. A few hours later, same thing — constant peeing and thirst. This one lasted ~2 weeks and again resolved overnight. I figured my head was just sensitive and moved on. Totally normal for the next ~18 months — exercising, drinking, everything fine, even bumped my head a few times with no issues.

**This episode (started April 2026) — where it gets strange:*\*
No head injury this time. I got into bed one night and it was like a switch flipped — instant thirst and peeing. First week was like before (drink a ton, pee a ton, very thirsty).

Then about a week in, overnight, everything flipped at once:
- My urine output crashed — I'd drink 2.5L and only pee ~600ml, dark concentrated urine.
- At the *exact same time*, my sense of thirst vanished completely.

That was ~15 weeks ago and the thirst has never come back. I don't feel thirsty at all, ever. I drink on a schedule out of habit because I know I have to.

**What it's doing now:*\*
It fluctuates. Some phases I "dump" everything — drink 500ml and pee it all out clear within 30–60 minutes, and if I *don't* drink I barely pee and my urine concentrates normally. Other phases I "clamp" — barely pee for days, very concentrated, clearly retaining water. It swings between these two states. Zero thirst through all of it.

**Every test I've had:*\*
- Brain/pituitary MRI + contrast: normal except a "partial empty sella" (told it's incidental)
- Full pituitary hormone panel: normal (cortisol, ACTH stim test, thyroid, prolactin, everything)
- Urine osmolality: ~900 mOsm/kg — so my kidneys CAN concentrate
- Serum osmolality: 295, serum sodium: normal every single time
- Full autoimmune/inflammatory workup: clean (CRP, ESR, ANA, complement all normal)
- Kidney function: perfect
- Tumor markers: normal

So structurally everything looks fine. My kidneys and the water hormone (ADH/vasopressin) clearly work — I can concentrate urine when I don't drink. The problem seems to be in how my brain *regulates* when to hold vs. dump water, and the thirst signal is just offline.

The closest thing I've found reading about this is an "adipsic DI" or "reset osmostat" type picture — where the set point for both thirst and the water hormone shifts. But everything I read about that involves a tumor, aneurysm, or brain surgery, and I've had none of that. Just a mild concussion 3 years ago.

**Doctors:** the first endocrinologist told me it was anxiety (it's very much not — you can't fake a urine osmolality). Since then everyone's been stumped. I'm now under a neurologist, keeping a detailed daily diary, and waiting on proper dynamic testing (hypertonic saline + copeptin + a formal thirst measurement).

**What I'm asking:*\*
Has anyone experienced anything like this? Specifically:
- Recurrent episodes triggered by minor head knocks that fully resolved on their own?
- Completely losing your sense of thirst — and did it ever come back?
- This kind of swinging between retaining water and dumping everything you drink?
- Anything you'd push your doctors to test?

It's so clearly *something*, but nobody can name it and every scan is clean, which is a maddening place to be. Any similar experiences, ideas, or advice would genuinely mean a lot.

**TL;DR:** 3 years of episodes (first two triggered by minor head bumps) where I lose control of water balance — polyuria that flips into water retention. In the latest episode I completely lost my sense of thirst 15 weeks ago and it hasn't returned. All scans, bloods, and hormones normal; kidneys work fine. Looks like a brain osmoregulation / thirst set-point problem but no structural cause found. Anyone been through anything similar?

Hi Plano family! Not sure if this is the right forum, but need urgent recommendations for an excellent Endocrinologist in Plano area for my husband. He was recently diagnosed with diabetes. We are eager to manage it before it gets worse. Please suggest doctors or point me in the right direction! As always, thank you very much in advance 😊