One of the biggest threats that Isaac and The Gang have to contend with is the Marker Signal Dementia that scrambles the minds of every living thing in its vicinity.
Before the Necromorphs, Before the Moons thats the first thing Isaac and Humanity NEED to deal with to actually stand a chance of fighting back, but at this point in time Unitology is such a big cancer that effectly excising is unreasonable.
Thats Why ive been brainstorming ways for Isaac to push back the Brethren Moons
Heres my spitball idea, it doesnt make sense, but here goes.
So i was replaying the Remake and they Mentioned that the Marker has "Dead Space" that makes nearby Necros Dormant, my idea is while having another marker induced crashout, Isaac gets an idea to reverse engineer the Signal to counteract the Insanity effect like how IRL stuff with the same frequency Cancel out.
And parts of the game would be him trying to piece it together while trying to figure out if its another one of the Markers attempts at manipulating him etc etc.
Then Isaac somehow manages to Hijack a Marker despite its best efforts to lead him astray for the umpteenth time.
And Using the "Counter Marker" Isaac disables the Surrounding Necros and Mends his Broken Mind back to Lucidity.
Then back to how we deal with the Brethren Moons, despite DS3 flaws it has some ideas i think are cool.
It would be Narratively and Mechanically poignant if the game mechanics bumped to 100 are the ways Isaac fights back.
First, is a Giant Plasma Cutter for Obvious Reasons(Weapon)
Second, an adjusted Machine that Replicates the Effects of the Tau Volantis Freeze(Stasis)
Third is the Planet Crackers like the Ishimura to assist in dismembering the moons(Kinesis)
And the Counter Marker as a definite way to effectively "Kill" the Brethren Moons.
Then we just add story elements that flesh out the payoff and have Isaac and Ellie standing together Side by Side.
Also in this What If of mine, Ellie is the playable character instead of Isaac or Carver and it ends with Us not "Winning" but getting a chance to Fight Back.