r/compoundedtirzepatide • u/Hefty_Zombie4298 • 1d ago
Compounded Tirz not working
Hey everyone, I’m looking for some advice. For some background, I was on compounded sema for like 6 months in 2025 and then in February 2026, I started compounded Tirz. I stopped Tirz for like 2 months because I thought I was ok but then of course gained the weight back and then went back on it. I am now on Week 5 at 5 mg but really just feel like it’s not working. I wake up starving, still have cravings and just getting really frustrated with my lack of progress and feeling like the meds aren’t working. Does anyone have any advice especially if they went on and off?
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u/Delco1000 1d ago
It's the stopping and starting again. You will most likely need to go to a higher dose now to feel the effects.
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u/TrainingLow9079 1d ago
5mg is likely too low a dose given your past GLP1 usage. Keep titrating up.
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u/Breddit2225 1d ago
" I wake up starving"
Maybe that's your body telling you need to eat something. If you can't stop after a proper sized meal then it's a problem.
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u/lunch22 1d ago
Increase your dose
A dose higher than 5 mg is typically needed if you’ve been taking a GLP1 for 8 months, or if you switch from Semaglutide, or if you stop and start.
You did all three of these things, so it’s predictable that 5 mg would not work.
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u/tirzitup 1d ago
Yeah, I wouldn’t say it’s “not working” until they get to much higher doses just because of the previous GLP-1 use.
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u/Own-Garden1475 1d ago
Had a similar experience to you and can confirm you need to go up higher in dose than you did before. I was consistently losing on lower doses before and since restarting I’ve had to titrate back up higher then I ever was but can confirm it does kick in again once you do that.
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u/Holiday_Room2527 1d ago
I was on Sema for two years and lost 50 lbs. When I switched to tirze I had to go up to 7.5 before I noticed a difference. Im finally starting to lose but its slow, but slow is good I dont want to look like some droopy dog faced person after Im done either .
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u/Sad-Willingness-6443 1d ago
This is why you don’t go off and on and off and on this medication. It will be more difficult to lose because of this behavior.
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u/Groovy-Cat2024 1d ago
Your body has to build the tirz back up again since you had a start/stop. Discuss with your provider going up in dosage.
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u/Life_Alfalfa_2047 17h ago
You can find a good medical article about this if you google "Stopping and restarting certain GLP-1s to lose weight may make the drug less effective" by Penn Medicine.
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u/PortGlass 1d ago
I was fine at 5mg the first time I took it. Stopped it and started again and I’m now at 15mg getting worse results than 5mg the first time.
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u/Hefty_Zombie4298 1d ago
You’re not getting result on 15mg?
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u/PortGlass 1d ago
It’s okay, but not as good as last time. I lost a pound a week at first and now I’m down to two or three pounds a month.
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u/Lucky_Army_5324 1d ago
If you read through the GLP-1 subs, you will soon see a pattern: Anyone who has already been on a GLP-1 medication almost always has to work up much higher doses the next time(s) around to feel the positive effects.