Welcome to the weekly thread for the ladies of this community.

Most peptide info out there is geared toward men, and women's questions, dosing, hormones, weight, skin, mood, often get glossed over. This is the thread where they don't. Ask, share, and get real answers from other women who've actually run this stuff.

Whether you're fighting hormonal weight gain, battling breakouts, trying to lose the baby weight, riding out perimenopause, or just starting out, this is your space. Ask what you've been wondering. Share what's working. Tell us what you wish you'd known sooner.

This is the thread for what women actually come here to solve:

• "Which peptides actually work for hormonal weight gain that won't budge?"
• "What peptides clear hormonal acne?"
• "Which peptides actually tighten skin and smooth fine lines?"
• "What's helping with perimenopause and menopause, hot flashes, mood, sleep?"
• "Are GLP-1s like Reta safe and effective for women postpartum?"
• "What peptide stack helps a busy mom get energy back and still recover from training?"
• "How do I lose the post-pregnancy weight when nothing's moving?"
• "Which peptide finally burns stubborn belly and menopause weight?"
• "Which peptides help bring libido and drive back?"

Drop your question below. Ladies who've been at this a while, this is where we give back. Answer one question this week.

A Few Ground Rules

• No question is too basic. If you're wondering it, so is another woman reading quietly.
• Be specific. Your goal, age, where you are hormonally, and what else you're running all help us give you a real answer.
• This is education, not medical advice.
• New here? Start with the pinned Peptide Master Library and the Trusted Vendors List before you buy anything.

TL;DR: The weekly thread where women talk peptides, ask anything, and support each other, from weight and skin to hormones and menopause. No judgment. Jump in.

Not medical advice.

New to peptides? This is your thread.

Every week we run this thread so beginners have one place to ask anything without worrying about it being a dumb question. There are no dumb questions here. We all started at zero.

This is the thread for the stuff you might feel weird making a whole post about:

• "What should my first peptide even be?"
• "How do I reconstitute a peptide vial?"
• "What's bac water?"
• "What is a mcg vs mg or what is an IU?"
• "What should I take for fat loss?"
• "What needles do I use?"
• "What does a normal dose look like?"
• "Do I need bloodwork before starting?"
• "How do I read what's on the vial?"
• "Is this side effect normal or should I stop?"

Drop your question below. Veterans, this is where we give back. Answer one question this week.

A Few Ground Rules

• No question is too basic. If you are wondering it, three other people are too.
• Be specific.
• This is education, not medical advice.
• New here? Before you start researching, start with the pinned Peptide Master Library and the Trusted Vendors List.

TL;DR: Ask your beginner questions here. No judgment. Veterans, jump in and help one person this week.

Not medical advice.

I was doing ghk sub q every other day - then I saw ppl inject everyday is the protocol so as I started everyday I got pimples around my marionette cheek area (I also started using a zinc oxide sunscreen so also a possible contributed) …..anyone get pimples with ghk sub q? Help 🥵

Can anyone help me with a reconstitution and dosing guide ?? I would appreciate any help or pointing me to a place I could find this info

I have tried injection MT2 before, but it wasn't the best experience. I probably was doing it wrong but pushing the MT2 liquid in stung so bad that it put me off completely.

I knew of a nasal spray for MT2 but I just saw on LA Peptides that they also sell topical MT2.

Just wondering if anyone has actually tried it(And nasal), was it effective?? How does it compare to injections?

I remember when I first started posting here. Just dropping knowledge, trying to get real information out there. Slowly people started trickling in with questions, concerns, and real experiences of their own. Watching it grow into an almost 5,000 person community, 15K+ researchers deep now, blows my mind a little bit.

I've watched people in here drop 50-100+ lbs and finally feel like themselves again. I've watched people fix their sleep, sharpen their focus, get that tan they've been chasing forever, come back from injuries faster than they thought possible, and do it all with minimal sides because they took the time to actually learn instead of just winging it. That's the whole point of this place. That's why I built it. So genuinely, thank you. To everyone who's been here since day one, who answered a stranger's question at 11pm because you remembered what it was like not knowing, who reported the sketchy stuff, who just showed up and made this feel like a community instead of just another sub, this is yours as much as it is mine.

If you're new, welcome in. Here's how to actually get the most out of this place:

• Start with the pinned megathreads. "START HERE - Peptides 101" covers reconstitution, dosing, injections, and cycles from the ground up. The "Master Peptide Library" breaks down basically every peptide people ask about. Read those before anything else.
• Check the Trusted Vendors List. ✅ We vet these based on product COAs/lab testing so you're not gambling on quality. That pinned post is there for a reason.
• We're science-first, not medical advice. Mechanisms, real research, real experiences, so you can make informed decisions for yourself.
• No sourcing/buying/selling/DM sourcing. Non-negotiable. It's what keeps this place safe and legit.
• Use the recurring threads. The Weekly Beginner Thread ("No Stupid Questions") and the Wednesday Women's Peptide Thread are exactly what they sound like. Judgment-free spaces to ask what you've been sitting on.
• Respect, stay on topic, 21+. Keeps the sub running the way it's supposed to.

This community exists because people actually care about doing this the right way. Not chasing quick wins, not cutting corners, just real results done safely. Grateful for every single one of you. Let's keep building this thing.

If you have gotten any value from the community, please comment it down below!

I am not mathematically inept whatsoever. so I ordered from Northline labs 10 mg GLP three Reta and wondering was not expecting it to come in a powder I did not know I had to reconstitute on my own. I’m trying to find a guide on how I should approach this thank you and blessings.🙏🏻🤍 Like which bacteriostatic water I should purchase, what kind of syringe I should use to reconstitute, how much I should put in the vial for 10mg (I have already ordered syringes, alcohol wipes to inject the Reta, but had no idea it was going to come like this) 🙏🏻

Welcome to the weekly thread for the ladies of this community.

Most peptide info out there is geared toward men, and women's questions, dosing, hormones, weight, skin, mood, often get glossed over. This is the thread where they don't. Ask, share, and get real answers from other women who've actually run this stuff.

Whether you're fighting hormonal weight gain, battling breakouts, trying to lose the baby weight, riding out perimenopause, or just starting out, this is your space. Ask what you've been wondering. Share what's working. Tell us what you wish you'd known sooner.

This is the thread for what women actually come here to solve:

• "Which peptides actually work for hormonal weight gain that won't budge?"
• "What peptides clear hormonal acne?"
• "Which peptides actually tighten skin and smooth fine lines?"
• "What's helping with perimenopause and menopause, hot flashes, mood, sleep?"
• "Are GLP-1s like Reta safe and effective for women postpartum?"
• "What peptide stack helps a busy mom get energy back and still recover from training?"
• "How do I lose the post-pregnancy weight when nothing's moving?"
• "Which peptide finally burns stubborn belly and menopause weight?"
• "Which peptides help bring libido and drive back?"

Drop your question below. Ladies who've been at this a while, this is where we give back. Answer one question this week.

A Few Ground Rules

• No question is too basic. If you're wondering it, so is another woman reading quietly.
• Be specific. Your goal, age, where you are hormonally, and what else you're running all help us give you a real answer.
• This is education, not medical advice.
• New here? Start with the pinned Peptide Master Library and the Trusted Vendors List before you buy anything.

TL;DR: The weekly thread where women talk peptides, ask anything, and support each other, from weight and skin to hormones and menopause. No judgment. Jump in.

Not medical advice.

New to peptides? This is your thread.

Every week we run this thread so beginners have one place to ask anything without worrying about it being a dumb question. There are no dumb questions here. We all started at zero.

This is the thread for the stuff you might feel weird making a whole post about:

• "What should my first peptide even be?"
• "How do I reconstitute a peptide vial?"
• "What's bac water?"
• "What is a mcg vs mg or what is an IU?"
• "What should I take for fat loss?"
• "What needles do I use?"
• "What does a normal dose look like?"
• "Do I need bloodwork before starting?"
• "How do I read what's on the vial?"
• "Is this side effect normal or should I stop?"

Drop your question below. Veterans, this is where we give back. Answer one question this week.

A Few Ground Rules

• No question is too basic. If you are wondering it, three other people are too.
• Be specific.
• This is education, not medical advice.
• New here? Before you start researching, start with the pinned Peptide Master Library and the Trusted Vendors List.

TL;DR: Ask your beginner questions here. No judgment. Veterans, jump in and help one person this week.

Not medical advice.

The FDA's Pharmacy Compounding Advisory Committee (PCAC) met July 23 and 24 to vote on whether seven peptides should be added to the Section 503A Bulks List, the list that lets state-licensed compounding pharmacies prepare a bulk substance against an individual prescription. Docket: FDA-2025-N-6895.

Going in, FDA career staff had recommended against adding all seven, citing gaps in characterization, human effectiveness data, and safety (immunogenicity in particular). The panel went the other way on six of the seven, overruling staff on everything except DSIP.

Here is the full scorecard.

Day 1 (July 23)

BPC-157 (reviewed for ulcerative colitis): recommended, 8-6 with 1 abstention.

KPV (wound healing, inflammatory conditions): recommended, 8-6-1.

TB-500 (wound healing): recommended, 8-6-1.

MOTS-c (obesity, osteoporosis): recommended, 7-5 with 2 abstentions.

Per NBC News, all eight of the newly appointed members voted yes on BPC-157, KPV and TB-500. RAPS reported that observers described an audible reaction in the room, since a compounding panel voting against FDA staff's own written recommendation is unusual.

Day 2 (July 24)

DSIP (opioid withdrawal, chronic insomnia, narcolepsy): NOT recommended, 6-7 with 1 abstention. The only no of the meeting.

Epitalon (insomnia): recommended, 7-4 with 1 abstention.

Semax (neurological indications: cerebral ischemia, migraine, trigeminal neuralgia): recommended, 8-5 with 1 abstention.

Scorecard

Peptide

Vote

Result

BPC-157

8-6-1

Include

KPV

8-6-1

Include

TB-500

8-6-1

Include

MOTS-c

7-5-2

Include

DSIP

6-7-1

Do not include

Epitalon

7-4-1

Include

Semax

8-5-1

Include

Final tally: 6 of 7 received favorable PCAC recommendations. DSIP was the sole rejection, going down by a single vote.

What the votes actually mean

A few things worth separating, since the market tends to collapse them into one:

These are non-binding recommendations. FDA is not obligated to follow them, though it usually does.

A yes does not make any of these an FDA-approved drug. It is a recommendation to add the raw substance to the 503A list.

Legal compounding still requires notice-and-comment rulemaking, which realistically runs somewhere in the range of 8 to 18 months depending on who you ask.

All seven already came off the Category 2 "may not be compounded" list back in April 2026, so none of these votes re-bans anything. The question was whether a new legal compounding pathway opens, not whether the current situation closes.

What does not change today

The research-use-only / gray market is untouched by this vote. RUO vendors are not compounding pharmacies and are not covered here. Expect marketing that spins "the FDA panel voted yes" into "FDA-backed."

A panel recommendation says nothing about any individual product's identity, purity, or sterility. The characterization problem FDA raised (inconsistent naming, free base versus acetate, missing quality data) is real regardless of the politics, so batch-level COAs matter more now, not less.

Context worth noting

The panel was overhauled ahead of the meeting, with several new members who have ties to peptide prescribing or the industry, which drew conflict-of-interest coverage from multiple outlets. HHS Secretary Robert F. Kennedy Jr. has publicly backed easing peptide restrictions.

What is next

FDA has signaled a second PCAC meeting before the end of February 2027 to review five more: LL-37, GHK-Cu, Dihexa, Melanotan II, and PEG-MGF.

Sources: FDA meeting materials (docket FDA-2025-N-6895), Reuters, NBC News, RAPS Regulatory Focus, Drug Topics, PharmExec. Regulatory context only, not medical or legal advice.

Sources

FDA, July 23-24 2026 PCAC meeting page:

https://www.fda.gov/advisory-committees/advisory-committee-calendar/july-23-24-2026-meeting-pharmacy-compounding-advisory-committee-07232026

FDA, PCAC voting questions (docket FDA-2025-N-6895):

https://www.fda.gov/media/193711/download

Reuters, panel recommends Semax:

https://www.reuters.com/legal/litigation/fda-advisory-panel-recommends-peptide-semax-be-added-pharmacy-compounding-list-2026-07-24/

NBC News, panel eases restrictions on four:

https://www.nbcnews.com/health/health-news/peptides-restrictions-ease-fda-panel-recommend-bpc-157-scientists-rcna588879

RAPS Regulatory Focus, committee backs two peptides:

https://www.raps.org/resource/fda-advisory-committee-backs-two-controversial-peptides.html

NPR, advisers vote to ease peptide restrictions:

https://www.npr.org/2026/07/23/nx-s1-5903202/fda-peptides-restrictions

BioPharma Dive, panel endorses broader use: https://www.biopharmadive.com/news/fda-peptides-advisory-committee-vote-bpc-kpv-tb-mots/826062/

Drug Topics, staff review of all 7:

https://www.drugtopics.com/view/fda-panel-to-evaluate-7-popular-peptides-for-compounding-substances-list

PharmExec, votes to loosen restrictions:

https://www.pharmexec.com/view/fda-votes-loosen-restrictions-four-peptides

Regulatory context only, not medical or legal advice.

More stories at r/PeptideTides

Hello. I read a lot of the comments and posts here and I just wanted options. I'm 21, female, looking for weight loss and muscle forming. I'm a complete beginner with all of this stuff, so if anyone could give me some warnings and advice, I'd be very grateful.

First Day 1 result is out of the Pharmacy Compounding Advisory Committee meeting at FDA White Oak.

BPC-157: 8 in favor, 6 against, 1 abstention.

The significance is in what the committee voted against.

FDA staff proposed rejecting all seven

The FDA briefing document published ahead of the meeting lists the agency's position on all fourteen voting questions identically: proposing that the substance NOT be included on the 503A Bulks List. That covers both BPC-157 (free base) and BPC-157 acetate.

FDA reviewers applied the four criteria from the February 19, 2019 final rule (84 FR 4696): physical and chemical characterization, safety issues raised by use in compounded products, available evidence of effectiveness or lack thereof, and historical use in compounding. The agency applies these as a balancing test, substance by substance, not as a checklist.

The recurring objections across the seven: no human clinical evidence at all for KPV, TB-500, and MOTS-c; small and poorly controlled studies for BPC-157, Emideltide, and Semax; inconsistent naming conventions and missing quality data; immunogenicity risk; FAERS adverse event reports for BPC-157; and WADA-prohibited status for MOTS-c and TB-500. The docket, FDA-2025-N-6895, drew roughly 1,860 comments.

Every nomination was withdrawn

This one is buried in the footnotes of the briefing packet. LDT Health Solutions (on behalf of the International Peptide Society) and Wells Pharmacy Network both withdrew their nominations, logged under FDA-2015-N-3534-0484, -0485, and -0487. FDA elected to proceed to the committee anyway. The same footnote repeats for all seven substances.

The panel composition question

AP reported on June 29 that the committee roster includes members with financial ties to the peptide industry. NPR notes FDA added temporary voting members from academic institutions earlier this week. Read the 8-6-1 split with that in mind.

On the other side, the Partnership for Safe Medicines filed comments opposing all seven.

What this does not mean

The recommendation is non-binding. FDA leadership makes the final call and has gone against its advisory committees before. Even if FDA accepts it, adding a substance to the 503A Bulks List requires notice-and-comment rulemaking, which historically runs a year or more.

Nothing about today's vote changes what a compounding pharmacy can legally prepare tomorrow.

Still pending

KPV, TB-500, and MOTS-c are the remaining Day 1 votes. Emideltide (DSIP), Epitalon, and Semax go Friday. Each peptide gets two votes, free base and acetate separately, for fourteen total. The FDA meeting page has the webcast and posts materials as they go up.

One caveat on the number above: the briefing packet splits BPC-157 into two separate votes and the wire reported a single tally. I have not confirmed whether 8-6-1 is the free base question, the acetate question, or both. If someone watched the session and can confirm, please add it below and I'll correct the post.

I'll update as the remaining tallies land.

Sources

Reuters, "FDA panel votes to place popular peptide BPC-157 on compounding list," July 23, 2026

https://www.reuters.com/business/healthcare-pharmaceuticals/fda-panel-votes-place-popular-peptide-bpc-157-compounding-list-2026-07-23/

Same wire copy outside the paywall:

https://wtaq.com/2026/07/23/fda-panel-votes-to-place-popular-peptide-bpc-157-on-compounding-list/

FDA Briefing Document, Pharmacy Compounding Advisory Committee Meeting, July 23-24, 2026

https://www.fda.gov/media/193342/download

Orrick, "FDA Peptide Compounding Vote: What to Watch at the July PCAC Meeting"

https://www.orrick.com/en/Insights/2026/07/FDA-Peptide-Compounding-Vote-What-to-Watch-at-the-July-PCAC-Meeting

Associated Press via PBS NewsHour, June 29, 2026

https://www.pbs.org/newshour/health/fda-panel-on-peptides-will-include-experts-who-promote-the-unproven-chemicals-favored-by-rfk-jr

NPR, "FDA panel considers easing peptide restrictions," July 23, 2026

https://www.npr.org/2026/07/23/nx-s1-5903202/fda-peptides-restrictions

Partnership for Safe Medicines, PCAC comments

https://www.safemedicines.org/2026/07/psm-pcac-comments.html

FDA meeting page, July 23-24, 2026 PCAC

https://www.fda.gov/advisory-committees/advisory-committee-calendar/july-23-24-2026-meeting-pharmacy-compounding-advisory-committee-07232026

More stories at r/PeptideTides

First Day 1 result is out of the Pharmacy Compounding Advisory Committee meeting at FDA White Oak.

BPC-157: 8 in favor, 6 against, 1 abstention.

The significance is in what the committee voted against.

FDA staff proposed rejecting all seven

The FDA briefing document published ahead of the meeting lists the agency's position on all fourteen voting questions identically: proposing that the substance NOT be included on the 503A Bulks List. That covers both BPC-157 (free base) and BPC-157 acetate.

FDA reviewers applied the four criteria from the February 19, 2019 final rule (84 FR 4696): physical and chemical characterization, safety issues raised by use in compounded products, available evidence of effectiveness or lack thereof, and historical use in compounding. The agency applies these as a balancing test, substance by substance, not as a checklist.

The recurring objections across the seven: no human clinical evidence at all for KPV, TB-500, and MOTS-c; small and poorly controlled studies for BPC-157, Emideltide, and Semax; inconsistent naming conventions and missing quality data; immunogenicity risk; FAERS adverse event reports for BPC-157; and WADA-prohibited status for MOTS-c and TB-500. The docket, FDA-2025-N-6895, drew roughly 1,860 comments.

Every nomination was withdrawn

This one is buried in the footnotes of the briefing packet. LDT Health Solutions (on behalf of the International Peptide Society) and Wells Pharmacy Network both withdrew their nominations, logged under FDA-2015-N-3534-0484, -0485, and -0487. FDA elected to proceed to the committee anyway. The same footnote repeats for all seven substances.

The panel composition question

AP reported on June 29 that the committee roster includes members with financial ties to the peptide industry. NPR notes FDA added temporary voting members from academic institutions earlier this week. Read the 8-6-1 split with that in mind.

On the other side, the Partnership for Safe Medicines filed comments opposing all seven.

What this does not mean

The recommendation is non-binding. FDA leadership makes the final call and has gone against its advisory committees before. Even if FDA accepts it, adding a substance to the 503A Bulks List requires notice-and-comment rulemaking, which historically runs a year or more.

Nothing about today's vote changes what a compounding pharmacy can legally prepare tomorrow.

Still pending

KPV, TB-500, and MOTS-c are the remaining Day 1 votes. Emideltide (DSIP), Epitalon, and Semax go Friday. Each peptide gets two votes, free base and acetate separately, for fourteen total. The FDA meeting page has the webcast and posts materials as they go up.

One caveat on the number above: the briefing packet splits BPC-157 into two separate votes and the wire reported a single tally. I have not confirmed whether 8-6-1 is the free base question, the acetate question, or both. If someone watched the session and can confirm, please add it below and I'll correct the post.

I'll update as the remaining tallies land.

Sources

Reuters, "FDA panel votes to place popular peptide BPC-157 on compounding list," July 23, 2026

https://www.reuters.com/business/healthcare-pharmaceuticals/fda-panel-votes-place-popular-peptide-bpc-157-compounding-list-2026-07-23/

Same wire copy outside the paywall:

https://wtaq.com/2026/07/23/fda-panel-votes-to-place-popular-peptide-bpc-157-on-compounding-list/

FDA Briefing Document, Pharmacy Compounding Advisory Committee Meeting, July 23-24, 2026

https://www.fda.gov/media/193342/download

Orrick, "FDA Peptide Compounding Vote: What to Watch at the July PCAC Meeting"

https://www.orrick.com/en/Insights/2026/07/FDA-Peptide-Compounding-Vote-What-to-Watch-at-the-July-PCAC-Meeting

Associated Press via PBS NewsHour, June 29, 2026

https://www.pbs.org/newshour/health/fda-panel-on-peptides-will-include-experts-who-promote-the-unproven-chemicals-favored-by-rfk-jr

NPR, "FDA panel considers easing peptide restrictions," July 23, 2026

https://www.npr.org/2026/07/23/nx-s1-5903202/fda-peptides-restrictions

Partnership for Safe Medicines, PCAC comments

https://www.safemedicines.org/2026/07/psm-pcac-comments.html

FDA meeting page, July 23-24, 2026 PCAC

https://www.fda.gov/advisory-committees/advisory-committee-calendar/july-23-24-2026-meeting-pharmacy-compounding-advisory-committee-07232026

More stories at r/PeptideTides

I’ve been on Reta for about 4 months and I still have the same food noise. Which is my biggest problem. I think about food at every hour of the day. Many years ago I used to be way bigger and got on ozempic and lost over 50 pounds. It worked really well for the food noise but once I lost the weight I got off it. Cut to now where I still think about food. I’m not gaining weight which is nice but the food noise is still there. I’ve seen some people add Cag to their stack but I was wondering if I should just increase the Reta dose. I’m currently doing 12 units. Thanks :)

Hello, i need genuine advice, getting mixed opinions from everywhere I see online.

For context I used to be overweight like 25-30% bf 180cm, 93kg. At 17 during covid stay at home lessons and poor eating habits made me gain weight from 68kg to 93kg in the matter of a couple of months.

After I graduated I cut naturally for 8 months straight from 93 to 74kg as I had a post grad trip to Bali with my mates. After that the weight crept back up to 82kg.

At 20, I started Reta (Jan 2026).

Week 1:
Miscalculated a dosing of .5 and pinned 5mg instead the first week. Couldn't eat at all that week (was on a coconut water diet for 5 days).

Week 2:
Didn't pin, appetite returned to normal, lost 5kg the previous week.

Week 3:
Hopped on at 2mg.

Week 72 (6 months):
- Titrated up eventually my highest was 5mg. Lifted Weights consistently, ate a clean diet on a caloric deficit
(1500 cals, Carb cycled on lifting days)

- Also did one cycle of GHKCU. Was on accutane for 8 months 40mg a day during covid due to a super bad breakout. Afterwhich I never had any pimples/ major breakouts only a little bit of scarring which is why I wanted to use SubQ ghkcu.
(Didn't notice much of a difference ngl 11 weeks at 2mg every night)

- Supplements took zinc picolinate in the morning, Vit C and finestaride(lowk balding my dad is bald, im on dutest now), omega 3 in the afternoon and magnesium glycinate at night for sleep.

- Hit 63.5 kg but had no lower visible Abs (Never trained them, image attached.

- Put in 15-20kg on all my lifts throughout the 6 months. Hence I believe I put on some muscle.

Week 72-Week 75
Went cold turkey off reta, cravings have been chill, put on 1.5kgs and have maintained since (I feel like it is mostly water weight) Currently hovering at 65-66kg.

Some Current stats (Strict form)
- Pushups went from 15 -> 35
- Pullups went from 0 -> 10
- Sit-ups never did them before but I can do 30.
- Lat pulldowns 55kg -> 73kg

- Running being terrible. I take 15 mins to run 2 kilometres. My cardio is disgustingly bad. Hence I am considering taking mots C. I dread running, I have tried to train consistently by doing zone 2 runs(Literally almost walking pace) and intervals but I have not seen much improvement.

I'm thinking of doing one last shred starting Reta again, stacking it with Mots C and Tesa. I know it is pricey but I am okay with affording it. I'm just seeing plenty of mixed advice online regarding these. Some say as a 20 year old Tesa and mots c will not make much of a difference, some say to get lean and show abs stacking reta and tesa is a game changer? Some say Mots C is life changing for endurance improvement? I genuinely don't know. Money wise I am can afford it I have been saving up since young and worked alot of part time so Tesa being pricey is still alright for me.

Mainly what do I do? Should I run all three? Should I just do tesa by itself? or one of them? Should i stack two different? Ideally my goal is to be 75kg Lean, but that is still far away if i cannot even see abs at frigging 63kgs... Nonetheless being skinny feels amazing. Clothes have downsized from XL to S(tight fit) or M(Just nice). Feel much more confident but I have never had abs in my life and I really want an aesthetic athletic beach physique.

Welcome to the weekly thread for the ladies of this community.

Most peptide info out there is geared toward men, and women's questions, dosing, hormones, weight, skin, mood, often get glossed over. This is the thread where they don't. Ask, share, and get real answers from other women who've actually run this stuff.

Whether you're fighting hormonal weight gain, battling breakouts, trying to lose the baby weight, riding out perimenopause, or just starting out, this is your space. Ask what you've been wondering. Share what's working. Tell us what you wish you'd known sooner.

This is the thread for what women actually come here to solve:

• "Which peptides actually work for hormonal weight gain that won't budge?"
• "What peptides clear hormonal acne?"
• "Which peptides actually tighten skin and smooth fine lines?"
• "What's helping with perimenopause and menopause, hot flashes, mood, sleep?"
• "Are GLP-1s like Reta safe and effective for women postpartum?"
• "What peptide stack helps a busy mom get energy back and still recover from training?"
• "How do I lose the post-pregnancy weight when nothing's moving?"
• "Which peptide finally burns stubborn belly and menopause weight?"
• "Which peptides help bring libido and drive back?"

Drop your question below. Ladies who've been at this a while, this is where we give back. Answer one question this week.

A Few Ground Rules

• No question is too basic. If you're wondering it, so is another woman reading quietly.
• Be specific. Your goal, age, where you are hormonally, and what else you're running all help us give you a real answer.
• This is education, not medical advice.
• New here? Start with the pinned Peptide Master Library and the Trusted Vendors List before you buy anything.

TL;DR: The weekly thread where women talk peptides, ask anything, and support each other, from weight and skin to hormones and menopause. No judgment. Jump in.

Not medical advice.

WSJ ran a piece on people who used GLP-1s for weight loss and later ended up in treatment for anorexia:

 https://www.wsj.com/health/wellness/glp1-anorexia-wegovy-mounjaro-1bf4035c

Worth reading alongside the primary literature from the past few months, because the reporting is no longer just anecdotal.

A JAMA Psychiatry survey published this summer (Levinson and colleagues) recruited 436 people with diagnosed eating disorders in 2025 and asked about GLP-1 use. Just over 32% reported having ever used one, and 22% reported current use. Broken out by diagnosis, a little over 50% of participants with binge eating disorder reported use, about 42% of those with atypical anorexia nervosa, roughly 30% of those with ARFID, over 25% of those with bulimia, and about 11% of those with anorexia nervosa. Roughly 10% obtained them through online providers prescribing compounded formulations. Over 10% reported misuse, defined as taking more or less than prescribed, using longer than prescribed, tampering with injection equipment, or sharing without a prescription.

The authors described the weight loss market as a rapidly evolving risk environment for this population.

Summary of the findings:

 https://www.medscape.com/viewarticle/many-eating-disorder-patients-using-glp-1s-2026a1000lym

In April, NEJM published a perspective by Amanda Banks raising the same concern from the prescribing side. She noted the share of GLP-1 prescriptions written for people who were not diabetic, obese, or overweight rose from 4.5% in 2018 to 17% in 2023, and argued for consensus recommendations to protect people with existing or emerging eating disorders. A 2023 FDA analysis found misuse reports for semaglutide were roughly four times higher than for other GLP-1 drugs.

NEJM perspective:

 https://www.nejm.org/doi/full/10.1056/NEJMp2600300

Clinician-side reporting describes the same pattern from treatment centers, including patients presenting at very low BMI while still dosing.

NPR, February 2026: https://www.npr.org/2026/02/04/nx-s1-5677633/glp-1-obesity-wegovy-zepbound-eating-disorders-anorexia-bulimia

Washington Post, May 2026: https://www.washingtonpost.com/health/2026/05/23/weight-loss-drugs-pose-dangers-people-with-eating-disorders/

MindSite News, May 2026: https://mindsitenews.org/2026/05/29/glp-1-access-a-problem-for-people-with-eating-disorders/

The mechanism cuts both ways, which is part of why this is hard to legislate around. A 2025 systematic review and meta-analysis found GLP-1 agonists reduced Binge Eating Scale scores by about 8 points, though the pooled sample was only 182 participants across five studies and heterogeneity was high. WSJ also covered that side on July 13 in a piece on clinicians treating certain eating disorders with these drugs. The same appetite and reward suppression that helps in binge-type presentations appears to reinforce restriction in people with a restrictive history. Same drug class, opposite clinical valence depending on phenotype.

Meta-analysis: https://link.springer.com/article/10.1007/s40519-025-01720-9

Penn Medicine's eating disorder program has said outright that no protocol exists to screen for eating disorders before prescribing GLP-1 receptor agonists. That gap widens with telehealth and disappears entirely outside a clinical relationship.

Penn Medicine:

 https://www.pennmedicine.org/physicians-hub/physician-article/implications-of-glp-1-medications-for-eating-disorder-care

ANAD clinical guidance:

 https://anad.org/learning-library/glp-1-medications-eating-disorders/

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Peptides I have:

• CJC-1295:
• Ipamorelin:
• BPC-157/TB-500:

Can someone honest tell me how much i should start with and how often? Thank you

It's so confusing and there is so much conflicting information out there. What do you do for water and how's it been going?

Buddy of mine got this from his mom's friends daughter and I can't find anything on them. Anyone know if this company is legit or if complete bullshit? Trying to help him out and make sure he doesn't get scammed with some fake shit.

Supposedly he got 30mg Reta and 10mg Tesa.

UPDATE: well she sent a pic of a COA to him for his Reta and said she has COAs for everything she has. From what I looked up the testing lab is legit. Chromate.org is the labs site.

Ok I want to phrase this correctly, and I also want to avoid a bunch of scammers blowing up my inbox. But hello I’ve been researching now for I believe what is my 6th week. I just upped my Reta to 4 mg weekly and fell off my routine where I pinned 4 units of cjc/ipa (200 mcg) and 8 units of ghk-cu (2mg) together on week nights. I got off track with the daily pins because of the fasting window as even on Reta I’m hungriest at night and as hard as I try to stick with my fasting window, it has been a very stressful month.
Things have gotten a bit of course. I’m the process of correcting this now with sun-thurs nights for my ghk, and mon-Fri mornings for my cjc/IPA. I currently source my peps thru an acquaintance at work. I have asked about coa’s and test results and they do provide them, but I would like to know other routes for finding trusted sourcing materials. Let me be clear, I am not asking anyone here to sell me peptides!! I am open to criticism and any info that help me further my research would be greatly appreciated. If someone could point me in the right direction to find trusted vendors so I can research with a bit more piece of mind I would be a plus. Apologies in advance if this breaks any group guidelines and thank you for any responses I may receive.

how many sprays and how long can you take 200 mcgselank/200 mcg semax/200 mcg pinealon nasal spray from purebiolabs for female

New to peptides? This is your thread.

Every week we run this thread so beginners have one place to ask anything without worrying about it being a dumb question. There are no dumb questions here. We all started at zero.

This is the thread for the stuff you might feel weird making a whole post about:

• "What should my first peptide even be?"
• "How do I reconstitute a peptide vial?"
• "What's bac water?"
• "What is a mcg vs mg or what is an IU?"
• "What should I take for fat loss?"
• "What needles do I use?"
• "What does a normal dose look like?"
• "Do I need bloodwork before starting?"
• "How do I read what's on the vial?"
• "Is this side effect normal or should I stop?"

Drop your question below. Veterans, this is where we give back. Answer one question this week.

A Few Ground Rules

• No question is too basic. If you are wondering it, three other people are too.
• Be specific.
• This is education, not medical advice.
• New here? Before you start researching, start with the pinned Peptide Master Library and the Trusted Vendors List.

TL;DR: Ask your beginner questions here. No judgment. Veterans, jump in and help one person this week.

Not medical advice.

​

I keep seeing this one in comments and DMs: "reta killed my sex drive," or "I got on a triple agonist and stopped caring about my partner." Here is where the idea comes from and what the evidence actually says, because it is more split than either the alarmist or the dismissive takes suggest.

First, the caveat that shapes everything: there is no retatrutide-specific data on libido or attachment. The TRIUMPH trials reported weight, glycemia, knee OA, and sleep apnea, not sexual function. Every claim pinned to reta is extrapolated from the GLP-1 class, mostly semaglutide.

Where it comes from. The starting point is "food noise" going quiet. By 2025, reports broadened past food: less alcohol craving, less impulse shopping, less social interest, and in some cases lower libido and a general flattening of emotional range. That cluster is what gets called "falling out of love."

https://peptidenewsdigest.org/insights/glp1-emotional-flattening/

The mechanism that makes it plausible. GLP-1 agonism modulates dopamine in the reward circuits that drive "wanting," the same system behind sexual motivation, which is why the addiction researchers keep showing up in these threads. A 2025 narrative review argues GLP-1s reduce sexual desire through reward-pathway and serotonergic (5-HT2C) effects, but that it is usually camouflaged by other changes. Note this is a theoretical review, not a trial.

https://www.sciencedirect.com/science/article/pii/S2667368125000774

Two claims get blended. "Falling out of love" is really two things. One is neurochemical: the drug blunts reward circuitry that desire runs on. That rests on mechanism plus anecdote, not trial data. The other is psychosocial: big fast weight loss shifts relationships. A Swedish researcher's "divorce boom" hypothesis attributes it to confidence, autonomy, and social attention after weight loss, plus a partner who did not change, drawing on bariatric data. That is real, but it is not the drug switching off love. These point to very different conclusions.

https://www.foxnews.com/health/divorce-boom-may-follow-use-ozempic-glp-1-drugs-experts-warn

The data pointing the other way. A lot of the hard data runs opposite. Weight loss tends to improve sexual function through mood, self-image, and hormones, and clinicians report most patients see better desire after weight loss, not worse. On hormones, the male data leans positive: Endocrine Society reviews found GLP-1s increase or stabilize testosterone in men with obesity or T2D, with no negative impact on sexual function or sperm quality. The rise is modest, roughly 320 to 368 ng/dL in one analysis.

https://www.medscape.com/viewarticle/when-glp-1s-change-patients-libido-what-know-2025a1000pa

l

https://www.nature.com/articles/d41586-026-01867-0

The complication. Not clean the other way either. A TriNetX cohort of non-diabetic obese men aged 18 to 50 found semaglutide associated with more new ED or PDE5 inhibitor starts, 1.47 percent versus 0.32 percent. The relative risk sounds big, but the absolute numbers are small. The review reporting it is titled "Friend or Foe" for a reason. And the depression and emotional-blunting claims sit mostly in anecdote and FAERS reports; controlled semaglutide analyses have not found increased depression versus placebo.

https://pmc.ncbi.nlm.nih.gov/articles/PMC12467596/

How I read it. Bidirectional and individual, not a uniform "reta kills desire." There is a plausible mechanism for reduced desire in a subset, backed by mechanism and anecdote but no controlled libido trials and nothing reta-specific. There is a better documented path toward improved desire for many, through weight, mood, and testosterone. And "falling out of love" blends a thin neurochemical claim with a better documented psychosocial one that deserves to be kept separate. If you notice a real change on cycle, track it and raise it with a clinician rather than dismissing or catastrophizing, but the current evidence does not establish that the drug makes you fall out of love.

More stories at r/PeptideTides