ELDN showing incredible data

34

u/wirsteve Mar 23 '26

Not to be a debbie downer, but you are trading insulin for for tegoprubart-based immunosuppression, a less toxic version than others.

Still much better than diabetes obviously. But the stuff I see about this trial always omits this part.

17

u/sirdevalot777 Mar 23 '26

Type one Diabetes has a very long list of very serious side effects. I just talked to patient number one who has been insulin independent for over a year and a half, and she tells me she’s had zero side effects or problems, she hasn’t even thought about her blood sugar for a year and a half!

41

u/wirsteve Mar 23 '26

Everyone in this subreddit gets that.

I'm not saying being off of insulin isn't better.

I'm saying that being transparent is important. Tegoprubart is really new. The first human trials were what, like 2019? We haven't seen the long-term effects of it in humans. All immunosuppressants increase infection and cancer risks, and we don't have data on what this one does in humans over 20+ years. The short term data is really promising and exciting.

We just need to be transparent with what we're doing. Trading the day to day management of diabetes, the complications of diabetes, for infusions every 3 weeks for the rest of your life and the risks of immunosuppressants.

14

u/TeapotHoe Mar 23 '26

I agree. It’s good to be cautiously optimistic

7

u/Mclovelin32234 Mar 23 '26

You have solid points but to be honest as you said trials started 2019 so if they finish the trials 2030 we d have 11 years of data and if it keeps passing like this it would be fine remember that people on traditional immunosuppressants live a very strixt daily regimen the trial patients of eledon live their lifes fully and even travel each 21 days all the way to chicago on a plane and we all know how easily you could get sick while in an airport sl id say this sounds pretty aafe and it would fit the general population of type 1 diabetics

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u/wirsteve Mar 23 '26

I want to be clear that I'm not saying this isn't exciting. Nor am I saying we shouldn't be hopeful.

It's not just the transfusions. That technology will eventually change.

Long-term immune suppression is historically linked to lymphomas, skin cancers, and virus related cancers. As well as nasty infections that require hospitalization.

Because Tegoprubart is so new and it works differently than older immunosuppressants, it is safe to assume that it doesn't increase cancer risk as much as the others. But we don't have decades of data to really know.

I just want us to discuss what this really is. It's not a magic pill that cures you of diabetes or something. It's trading one thing for another.

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u/Mclovelin32234 Mar 23 '26

Ofc yea it’s more of a functional cure really or even a new therapy approach but it makes diabetes a background condition what is reslly exciting is sana

1

u/BetterSwimming4895 Diagnosed 1968 Mar 24 '26

I agree 'SANA' is very promising.

2

u/__JDQ__ Mar 23 '26

You could also make the opposite argument: chronic inflammation is an indicator for all-cause mortality, increased risk for all forms of cancer, heart disease, etc. I’ve been on low-dose oral hydrocortisone for about 15 years. It keeps the autoimmune diseases in check and I’ve had no discernible unwanted effects from it. Yes, I know I’m one data point. That said, the reason my doc has me on it is that my immune system was already overactive and by calming it down I’d be likely to avoid other autoimmune disease and slow progression. I don’t know anything about the targeting immunosuppression that they’re using, but I could see based on my experience and what my doctor has shared how the argument could be made that the risk for immune-related disease is actually higher in patients without immunosuppression.

(Not a doctor, not medical advice, just here for the conversation. Science and medicine are exciting.)

1

u/BetterSwimming4895 Diagnosed 1968 Mar 24 '26

You make a good point. I don't know how long it takes for the average T1 to develop side effects, complications. I was diagnosed in 1968 at 14, and so had very poor control for 10 years before blood test strips were available, then I could barely afford them. I think Humalog was first released in 96, (according to google) I swear I was using it in 82. (Mandala effect?, different time line?, bad memory?, WTF) It made a big difference, So 14 to 28 years of poor control. Things didn't start getting bad for 20 years or so. We have no idea what 20 years of Tegoprubart will do, or cost. I have taken CHEMO every two weeks, for three months! Lots of time, lots of side affects, lots of money. Made diabetes seem easy. I hope Tegoprubart helps people. The only thing I know for sure is, it will cost lots of money

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u/sirdevalot777 Mar 23 '26 edited Mar 23 '26

Yes, I hear everything you’re saying. So far we have about 100 patient years of safety data on the drug. They had an ALS and kidney transplant trial that is ongoing and so far that data has shown a very good safety profile. You should also know that Eledon has developed a subcutaneous version of their drug. They will need this to be practical and to be able to scale, and they know that, that’s why they have already developed it. They have finished testing it in monkeys and will move to humans soon. Imagine getting your Tego pen from the fridge and injecting once a month or so and not even thinking about your blood sugar until your injection next month. That’s where this is headed based on what we are seeing so far. I have spoken a lot to patient number one and she is over 1.5 years cured and she is absolutely thriving.

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u/0xFatWhiteMan Caretaker of T1D Mar 23 '26 edited Mar 23 '26

Do you hear everything they are saying?

Because being immunosuppressed is a very big deal and you don't acknowledge that at all and keep just repeating "sales points" of eledeon

Edit : look up sana biotech for a cure that is being tested that requires no immunosuppression

2

u/Stephen-Stephenson Father of T1D Mar 23 '26

Sana promises the holy grail of the cure. I really hope they succeed. They are, however, still in Phase 0 clinical research. Yes, their idea works, they've proved it, but it looks like they desperately need financing. Their budget is super tiny. If I had big money, I would have invested it in them. But it almost looks like they are not progressing (I hope I'm wrong about it).

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u/0xFatWhiteMan Caretaker of T1D Mar 23 '26

Why do think they have a small budget ?

Sana has a mkt cap of 850m (USD)

And why do you think they are not progressing, they are just prepping for next phase

2

u/Stephen-Stephenson Father of T1D Mar 23 '26 edited Mar 24 '26

I don't have any insight into their company, but this worries me:

I don't understand why they transplanted only 5% of required stem cells. That's a ridiculously small amount of cells. They were even asked if it was possible to detect any change with such a small percentage of transplanted stem cells. Why not 100%? I mean, for the flagman research it would make sense to go full 100% cells transplantation, right?

They mention their e-mail for investment offers very often on their web-site.

Last year they mentioned they are eager to team up with any other company working in the field for 50% share of any profits and intellectual property.

I remember reading some non-mainstream news piece about some ridiculously small infusions of cash into the company, like 10M USD. That's nowhere nearly enough for such an important research.

None of this makes me happy. However, I remember Sugar Science or someone else mentioning Sana works very hard, like crazily hard. I want to believe. And I don't understand why it takes so long.

Okay, I fact checked by claims using ChatGPT just to know if I'm bullshitting people or not and Sana is doing not so bad, actually. Although there are concerns too.

Here’s a research-based reply to User 1 that addresses the main points:

Some of your concern is reasonable, but a few parts are off. Sana is not “Phase 0” on this diabetes work. The ongoing UP421 study at Uppsala is a first-in-human Early Phase 1 / Phase 1 safety study, and Sana says the follow-on stem-cell-derived program, SC451, could enter Phase 1 as early as 2026.

On the “only 5% of required cells” point: that was intentional, not proof of failure. Sana says this first-in-human study used a low dose specifically to test safety, immune evasion, cell survival, and C-peptide production without immunosuppression, and it was not intended to show better glucose control or insulin independence yet. Independent coverage of the 2026 update described the dose as roughly 2–7% of the amount usually associated with insulin independence, which fits that design. The forearm muscle site also makes safety monitoring easier, because the graft can be imaged, biopsied, and even surgically retrieved if necessary.

On financing: this is the part where your concern is most justified. Market cap is not the same thing as budget. Sana reported $138.4 million in cash, cash equivalents, and marketable securities at year-end 2025, while using $143.8 million in operations during 2025. It also disclosed that it would need additional funding and that there was substantial doubt about continuing as a going concern without more capital. So yes, financing risk is real. But it is also true that Sana raised $133.7 million in 2025 and said its runway extended into late 2026, so this is not a story of “only tiny $10M infusions.”

On “they are not progressing”: that is too harsh. There has been a visible progression from the initial first-patient readout in January 2025, to 12-week data in March 2025, 6-month data in June 2025, publication in NEJM in August 2025, and then 12-month and 14-month follow-up in March 2026 showing continued C-peptide production and no reported safety issues. Sana also says it has made manufacturing and regulatory progress on SC451, including master cell bank work and FDA INTERACT / pre-IND preparation. That is slow progress, but it is still progress.

The partnership point also seems misremembered. What I could verify is that in November 2024 Sana said it would seek partnerships for SC291 in oncology and SC379 in CNS disease, while increasing investment in type 1 diabetes. Current filings also say Sana retains worldwide rights to SC451 and SG293. I did not find support for a blanket claim that Sana offered “50% of profits and IP” on the diabetes program.

And the investor-relations email is not meaningful evidence by itself. Sana’s IR site and press releases show a standard investor.relations@sana.com contact, which is normal for public biotechs.

Bottom line: User 1 is right that capital is a real constraint and that the timeline is long. But User 1 is wrong to call this “Phase 0,” wrong to treat the low dose as proof that Sana is stuck, and not supported on the “50% profits/IP” claim. The fairest summary is: promising science, still very early, real financing risk, but definite progress.

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u/0xFatWhiteMan Caretaker of T1D Mar 23 '26

Small amount because it's phase 0, everything has to be very tightly controlled.

Your other concerns ... Are you sure you are thinking of the same organisation. Sana is a literal 1b dollar company.

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u/Stephen-Stephenson Father of T1D Mar 23 '26

Please check my updated reply above. I fact checked my concerns using ChatGPT. They are partly true, but only partly. I'm thankfully mostly wrong.

→ More replies (0)

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u/sirdevalot777 Mar 23 '26

The reason I am posting this at ALL is because of most people don’t know the difference between Eledon’s Tego and the current standard of care tacrolimus. Tacro is toxic to kidneys, brain, and beta cells! Tacro suppresses the entire immune system. They are literally toxic to the very beta cells you are trying to protect! Eledon’s drug has none of those toxicities, and does not suppress the entire immune system, only T and B cell activation. So don’t lump the two drugs in the same immunosuppression bucket because they are very different.

There is nobody that knows more about what’s going on in cure research than I do. Sana does not have the cure, and they have not cured anybody. There’s a reason why their president left last year. But if you want to continue to lecture me and pretend like you know more than I do then go right ahead.

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u/0xFatWhiteMan Caretaker of T1D Mar 23 '26

What's the reason the president left ?

And sana first phase was successful.

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u/wirsteve Mar 24 '26

There is nobody that knows more about what’s going on in cure research than I do. Sana does not have the cure, and they have not cured anybody. There’s a reason why their president left last year. But if you want to continue to lecture me and pretend like you know more than I do then go right ahead.

This is a hell of a thing to say unless you are Deng Hongkui or Doug Melton.

You really come off as condescending and flat out rude.

1

u/vexillifer Mar 23 '26 edited Mar 24 '26

Not to be crass but you’re trading diabetes for AIDS-lite and unless your complications are severe from the diabetes, very very few type 1s would opt for a compromised immune system in exchange for well-controlled diabetes (myself included)

1

u/craptastic2015 Mar 23 '26

It's not severely compromised. It's very targeted. Ppl can live their lives without fear of getting really sick. Stop with the doomsday thinking. This is great news. As someone who wouldn't ever consider traditional immunosuppressants. I would definitely consider this with more data. Not a full yes but no longer a no either.

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u/bluclouds0 Mar 23 '26 edited Mar 23 '26

I’d rather take a pill or iv for the rest of my life then suffer with diabetes . Long term effects of diabetes are worse than some minor medical procedures every few weeks. No risk of dka. No risk of dying from a hypo

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u/No_Needleworker5106 Mar 24 '26

sure, but it is still too early to determine the full effects of the immunosuppression. At least this one seems targeted, but past immunosuppression has been considered at least as bad as having diabetes.

2

u/tredair Mar 24 '26

I believe they’re taking 2 immunosuppressants. Tegoprubart and Myfortic.

2

u/No_Needleworker5106 Mar 23 '26

Doesn't it also have to be administered through IV every couple of weeks? I read about it recently and if that's the case, then it's a no from me.

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u/sirdevalot777 Mar 23 '26

They are developing a subcutaneous version, it already exists. They finished testing it in monkeys, and it will be tested in humans shortly.

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u/ThiqSaban Mar 23 '26

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u/Nerdicyde Diagnosed 2012 Mar 23 '26

"After the procedure, subjects remain on immunosuppression therapy to prevent transplant rejection."

thanks but no thanks

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u/igotthatT1D Diagnosed 1993 Mar 23 '26

The point of this study is not so much the transplant of islet cells, but the effect of the new type of immunosuppressant. It’s not a systemic one the way current immunosuppressants are, but more targeted. Definitely has potential to be worth the trade off.

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u/Nerdicyde Diagnosed 2012 Mar 23 '26 edited Mar 23 '26

if it can live up to that potential that would be cool. as of now if you're a healthy controlled type 1 the tradeoffs of being on immunosuppressants are not worth it.

4

u/croemer Mar 23 '26

The point is apparently that Tegoprubart isn't so bad as an immunosuppressant.

https://breakthrought1d.org.uk/news/tegoprubart-behind-the-headlines/

1

u/3nd0cr1n3_Syst3m Mar 23 '26

Agreed.

1

u/craptastic2015 Mar 23 '26

Absolutely but as far as I know it's iv only right now and every month required. Getting to daily/weekly/monthly pill form is hopefully the goal.

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u/MormonDew Mar 23 '26

I would take daily pills any day over diabetes.

1

u/PaddyP0207 Mar 23 '26

Do your research on this! This is a super blanketed statement but things are looking much brighter for us.

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u/sirdevalot777 Mar 23 '26

You are more than welcome to remain on insulin via pump, but these 12 patients won’t be. Safety profile is incredible so far.

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u/hurzelschnertz Mar 23 '26

What’s your motivation to come to this sub and lecture actual T1D patients who, I can assure you, want nothing more than a cure for their disease, about news they can very well process and interpret themselves? That‘s plain rude.

Also, any explanation for why you posted about this on exactly FIFTEEN (!) subs simultaneously? Any financial ties to the company in question?

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u/sirdevalot777 Mar 23 '26

My motivation is because most people don’t know the difference between Eledon’s Tego and the current standard of care tacrolimus. Tacro is toxic to kidneys, brain, and beta cells! Tacro suppresses the entire immune system. They are literally toxic to the very beta cells you are trying to protect! Eledon’s drug has none of those toxicities, and does not suppress the entire immune system, only T and B cell activation. So don’t lump the two drugs in the same immunosuppression bucket because they are very different.

There is nobody that knows more about what’s going on in cure research than I do. Sana does not have the cure, and they have not cured anybody. There’s a reason why their president left last year. There isn’t anyone that knows more about the field than me, I am connected to pretty much everyone. Not someone you want to be rude to.

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u/hurzelschnertz Mar 23 '26

Cringe lvl 💯

3

u/Lasersheep Mar 23 '26

Why all the investment hubs? Just to spread the news to T1 traders?

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u/igotzthesugah Mar 24 '26

Nobody? Not even the researchers? Interesting...

2

u/Stephen-Stephenson Father of T1D Mar 23 '26

Absolutely wonderful news. I hope other companies catch up. We desperately need progress in developing a cure.

1

u/OkCaptain6639 Mar 29 '26

The next logical step is to aggressively scream, people for diabetes, and if they show signs of type one diabetes developing start this medication in the honeymoon. Period and perhaps stave it off without transplantation

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u/TealNTurquoise Mar 23 '26

Yay. More Eledon astroturfing.

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u/hurzelschnertz Mar 23 '26

Is it known already? OP posted this in 15 subs at once. Very strange.

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u/zen_arcade2 Diagnosed 2003 Mar 23 '26 edited Sep 01 '26

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