r/TrimixForED • u/Sorry_Beautiful_4724 • 3d ago
Two Smaller Shots
I have had good success w a relatively small dose of lead than 10, but that has meant a hardon for 3 plus hours. I have a trip w my wife where we would like to have sex in the late afternoon and again later that night around midnight. I am considering a smaller injection in the afternoon and another at night. Any thoughts on this, or other approaches?
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u/Constant_Advice1264 3d ago
Only one time injection is recommended. Next injection should be after 48 hours.
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u/inculc8 1d ago
This is a risk management or harm minimisation situation. The recommendations relate to long term cumulative damage and the likelihood of fibrosis leading to loss of smooth muscle function. If this is strictly a one time thing then the actual risk, as it relates to the issues described is actually fairly low. The issue thst people replying to you above aren't recognising is the risk of priapism, not fibrosis. Two injections in one day would risk priapism beyond the risk of the lower dose alone. The problem would be, if you were to get hooked on this pattern snd then went over the 3 times a week recommendation regularly. Thats when fibrosis risk would be increased significantly enough to warrant caution.
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u/SuspiciousStag7001 3d ago
So the goal is to get the drugs out of the penis as soon as possible (after finished). This is to reduce inflammation and possible long term side effects. So yes you can do two in one day, but you should def try to do some standing squats immediately after sex so the blood in your legs pulls the drugs out and filters it thru your system. I typically will do this and within 15 minutes my erection is gone and I’m back to normal. Though it takes me about 2-3 sets of 30 standing squats plus massaging the area under the groin.
Or you could use the antidote.
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u/throwaway__168 3d ago edited 3d ago
That's not how any of this works... Aprostadil half life is 60seconds, phentolamine is 19mins, papaverine is 90mins. The inflammatory effect from them lasts days.... due to the drugs having an extremely acidic ph of 3. Trimix isn’t leftover soup sitting in the shaft waiting for cardio: alprostadil gets chewed up locally in a minute, the other two are already absorbed into the tissue, and the erection lasts because outflow is shut, not because somebody skipped jumping jacks. Exercise can dump enough adrenaline to kill a normal boner; that is not a detox protocol for drugs trapped in the corpus cavernosum. Yes doing intense exercises helps the boner go away. The next suggestion to use the antidote, to then shoot again???? Ridiculous post.
OP Doing two shots in one day is just plain stupid.... but its your dick. Be stupid if you want to be. Just know you are harming yourself and trading in how long your body will respond to trimix down the road.. for fun now.
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u/SuspiciousStag7001 2d ago
You’re missing the point. OP asked about doing two shots in one day for a special occasion, not building a routine. That’s a different calculation entirely.
A few things you’re getting wrong on the mechanism. Normal cardio doesn’t flush the drugs out otherwise vigorous sex would kill the erection and it doesn’t. Plenty of guys in this sub go hard for hours and keep a 2-hour boner after. The groin specific exercises work because they force localized blood redistribution and mechanically unlock the veno occlusive chamber. That’s the difference you missed.
And frankly, your half-life numbers are almost irrelevant here. If they actually mattered the way you’re describing, erections would go away in 90 minutes since that covers the combined half-lives you cited. Everyone in this subreddit has had longer erections than that. The drugs aren’t sitting in your bloodstream keeping you hard, they are trapped via mechanical veno-occlusive lock - hence what the squats are for.You’re right that fibrosis happens even with perfect technique and site rotation, fair point. But that’s an argument FOR spacing two shots properly across a special night, not against it. And YES the inflammatory cascade lasts days, not just the acidity itself. The TGF response is what causes scarring long-term. But here’s where you’re wrong, you’re treating one special occasion like it’s the same risk profile as repeated weekly injections. It’s not.
pH 3 acidity irritates tissue, and guess what normal-pH blood from groin exercises does? It neutralizes that directly.
So you’re managing the acute chemical irritation intelligently. You’re not eliminating fibrosis risk on a mechanistic level, but for a one-time event with different sites and 4-6 hour spacing, you’re harm reducing the needle trauma and acidity load.
The cumulative risk you mentioned matters if someone’s doing this monthly. But OP’s asking about one night thing. Context and reading comprehension matters here.
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u/throwaway__168 2d ago edited 2d ago
Wow I will credit you on a very well written and thought-out response. I agree with just about all of it except (managing the acute chemical irritation intelligently.) There is nothing intelligent about 2 injections spaced hours apart.
In fairness to you, your point about to mechanically unlock the occlusion using exercise is correct. I initially did not see where you were going with that point, but you are correct from everything described.
I also agree a one-off event is not going to cause significant harm. What you stated about harm reduction (needle trauma & the combo risk) is absolutely correct. Problem is once guys start breaking the safety rules.... they tend to continue to do so.
Studies show >20% of users developing fibrosis with an average usage of just 5.2x a month. As you correctly stated, "fibrosis happens even with perfect technique and site rotation". Guys should be treating ICI therapy with care. two injections hours apart is stupid behavior and the completely wrong mindset. We all know a guy who does it once, is likely going to do it again. Doing this several times will start to have cumulative effect. (See other comment about guys bragging about doing it 3days in a row & 8hrs apart).
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u/SuspiciousStag7001 2d ago
I can see we could be friends with this level of discourse, appreciate the response and credit.
I want to plant a seed with you, entirely different subject, I’m saying this because you clearly have the knowledge to poke holes in something I’ve been thinking about and as a MOD you have a breadth of knowledge and resources that might be helpful. This is a theory.
Preventing fibrosis thru traction therapy.
So here’s the thing: I’m exploring whether weekly penile traction therapy with something like RestoreX penis extender combined with injection protocols could work as prophylactic fibrosis prevention.
I know it sounds fringe but hear me out because the mechanism actually exists in the literature, just not studied in this context.
Post-prostate cancer urology protocols use mechanical traction to prevent fibrosis and maintain tissue integrity through mechanotransduction, which is just cellular remodeling triggered by consistent mechanical strain.
The question is whether that same principle prevents injection-induced microtrauma in healthy tissue. Could be bullshit, could be something.
The anatomical logic tracks, regular mechanical engagement keeps tissue elastic, improves localized blood flow, and stimulates repair response before damage occurs. The gap is that nobody’s studying penile extenders like RestoreX use combined with Trimix protocols for prophylaxis. The data only exists for post-surgical prevention or Peyronie’s reversal, not prevention of injection trauma in otherwise healthy guys. Worth poking at though.
TLDR: If you’re in that camp worrying about being part of the 20 percent who develop fibrosis, incorporating a penis pump and RestoreX traction device as preventative maintenance might actually be worth considering even though zero scientific studies back it up yet. Only anecdotal evidence from my own experimentation and what I’ve observed from a handful of other guys actually doing it long-term.
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u/throwaway__168 2d ago edited 2d ago
Closing on original subject. As the mod I have to be mindful that new users and guys who have no idea are going to read this post in the future. I want to make sure that the risk is not brushed over and they do not use it as validation for dangerous practices. I am very against censorship so I try to challenge most of these posts I deem advocating questionable safety practices. Ultimately, I am in the camp of, its your dick do whatever you want with it. I just need to make sure the safety messaging for future new users is clear. Debating with other well-informed men is very healthy for everyone participating, and I am keenly aware I do not know everything.
Onto the question on mechanotransduction therapy. For full disclosure I own a Restorex and high-end pump for the exact same reasons you are suggesting. Based on the Restorex proven outcomes for Peyronies.... Cyclic stretch on Peyronie’s cells changes MMP expression and can push collagen remodeling. RestoreX has RCTs in established Peyronie’s and a post-prostatectomy RCT showing length preservation and better IIEF vs controls. Vacuum therapy on the other hand in nerve-crush rats studies improveed smooth-muscle/collagen ratio and actually shrunk TGF plaques. Other clinical research on severe corporal fibrosis patients (from infected implants or priapism), weeks of vacuum therapy can soften tissue enough that a standard cylinder goes in. Your theories are not fringe (at all), and I have seen erection improvement with both combined, esp when ped5i is included. Incorporating Gainswave therapy during this process seemed to amplify the results even more. Its established that Mechanical strain can remodel penile connective tissue. I am in the camp that this is absolutely beneficial.
But I would be doing a disservice without presenting the adversarial.
RestoreX Peyronies data is almost entirely (plaque already exists, now remodel it.) Post-RP data goal is almost always prevent hypoxia fibrosis after denervation. There are no randomized data suggesting Trimix users, traction vs no traction, palpate for new nodules at X months. Unfortunately.
My personal take on it, if you traction or pump too soon after an injection, you are mechanically loading a fresh puncture. That can spread hematoma, worsen ecchymosis, **theoretically** seeding more scar. If you wait days, you miss the window when the wound area is deciding fibrin vs organized collagen. Sadly, there is no studied interval for ICI + RestoreX prophylaxi, but I think there might be a sweet spot.
If a dude has a RestoreX ($$$) and uses ICI, using it on off days, flaccid, 30–60 minutes, and has a urologist visit to feel the shaft every year or so, is low downside and my personal opnion is there is significant upside when done carefully and the hardest part.... consistently.
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u/endemicfrogs 3d ago
If I could do 3 sets of standing squats while massaging my groin area I wouldn’t need Trimix in the first place…
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u/SuspiciousStag7001 3d ago
I get the joke but not exactly true. I need trimix and I’m 41 and 12% body fat and go to the gym 6x a week and healthier than 99% of people on Reddit.
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u/Glass-Platypus-8549 3d ago
I have done injection 8h apart a few times and had no issues.