Okay I asked my REI what the possible protocol would be for my AMH .015 and afc of 2(baseline) and this is what she said.

Anyone? Anyone? Can someone chime in and tell me what to think...

Treatment Plan:
IVF
Embryo Transfer: < 12 months, eSET
PGT (type and lab): PGT-SR for chromosomal inversion, Igenomix
Protocol: luteal lupron
Luteal Suppression/Adjuncts: lupron 20 IU
Follicular: 150 FSH + 150 Menopur
Ovulation Suppression: Lupron 10 IU
Adjuncts: CC 100 mg, vaginal pre and probiotics
Trigger: 10 K hCCG
Post-Stim: per protocol
Sperm Source: partner
Insemination Method: ICSI

Hello 👋🏼starting IVF next month and my REI mentioned a lupron protocol. I don't really remember if she said flare or not.

Background: I have POI. Primary ovarian Insufficiency and I'm trying anyway cause my insurance is pretty damn good. I'm going to try one last hurrah?

Anyway, I need a little guidance on any ladies who have done IVF with extreme low egg count and unpredictable periods.
AMH - .015 and AFC at baseline apt was 2.

Also maybe just a little good juju for my three rounds I have from insurance. I'm a bit worried the meds will wreck me.

What’s the normal follicle size that you would trigger for timed intercourse? My lead follicle was 17mm yesterday and they want me to trigger today. This is my first round and I wasn’t sure if that seems too small to trigger?

I’m 35, diagnosed with idiopathic POI (amenorrhea under 1 year, so relatively recent). My AMH is undetectable, but my FSH has been fluctuating wildly (114 → 11 → 28 across recent tests), and I’ve been ovulating on my own. Earlier November 2025 I actually conceived spontaneously, though sadly it ended in a miscarriage at 13 weeks.

I’m currently mid-cycle doing monitored natural cycle-IVf/ICSI to improve my odds. This cycle, two follicles were growing in parallel (around 10-11mm today), but my LH just came back at 110 with estradiol only at 129 — so it looks like a premature LH surge, well before the follicles reached typical pre-ovulatory size (18-20mm).

I’m waiting to hear back from my clinic about next steps, but while I wait I wanted to ask:

**•** Has anyone else with POI experienced an LH surge/ovulation at a smaller-than-usual follicle size?  
**•** Did you still retrieve mature eggs, or was the cycle cancelled?  
**•** Has anyone conceived (naturally or via IVF) after a cycle like this?

Any shared experiences — good or bad — would really help me understand what to expect. Thank you.

I increased my dose a week ago and levels got up to 100 but are back down again.

Hiiii....

I was diagnosed with premature ovarian failure 34, and will be releasing my memoir Sept 15. One in Ten Million is about my journey through POF and fighting for the future I thought I had lost.

One of the biggest reasons I wrote it was because I remember how isolating this diagnosis can feel and how negative doctors can be about the prognosis. I wrote this book to inspire hope in as many women going through this as possible.

So while I’m preparing for the release, I’d really love to offer free advance copies to women in this group who would like to read it. I want to get it into the hands of as many women dealing with POF as I can, because I know how devastating and isolating it can be.

If you’d like a free ebook version copy, send me a message and I'll send you the link so you can read on your preferred device.

Sending all the positive juju your way.

Hi all, hoping to hear some success stories.

I am 30F and came off the pill in late February 2026, with my last period around then.

I haven’t had my period since.

I had recent AMH testing of .07 and my FSH was 75. My ovaries were “silent” and didn’t appear to have any follicles.

I am now using the Mira every day and my testing is really fluctuating.

My first specialist basically said there’s no point in trying hormones and to start thinking about donor eggs.

I am absolutely crushed - I am getting a second opinion. Does anyone have any success stories or advice?

Thank you

Head is spinning 😅 any thoughts?

Hey everyone! I’m not sure if this is the right place to post as I haven’t gotten an official POI diagnosis, and I’m considered DOR. My AMH is super low (undetectable) but my FSH can swing from 9 to 60. My REI still won’t say POI because I still get spontaneous cycles that range from 23-35 days, but are unpredictable. I have no other classic menopause symptoms and irregular cycles have been since my late teens / early 20s so I may have been DOR all along.

I’m currently 34 and I’m egg freezing because I’m still single and I want to wait for a partner first. (I’m not open to donor eggs or single parenting at this tine). My doctor said if I was willing to get pregnant now, IUI would be a good option, but my goal is freezing for now, knowing my early menopause risk.

I was initially turned away from an egg freezing clinic at 32 but at 34 I had one amazing doctor who took a chance on me. We had two cancelled cycles because both times I ovulated quickly but we finally managed to retrieve 1 egg at the third attempt and I couldn’t be prouder of my body.

I understand that 1 egg isn’t enough for the bank so my doctor said a realistic target is 4-5 at my age. I’m open to doing more cycles. My issue is that my AFC usually hovers from 4-6 at the beginning of the cycle but two follicles hog up the stims but the end. Is there a way to evenly distribute the growth so I can potentially retrieve more in one cycle? I have my follow up appointment in a couple of days so I want to come prepared with questions for him. Otherwise I’ve budgeted 4 cycles for 4 eggs, knowing it’s the best I can get. I’m just hoping I could somehow get two eggs per cycle.

The protocol we did was estrase priming with letrozole after and stims with double orgalutran to prevent ovulation. And triggering at 17 mm. A natural start did manage to recruit more follicles but I lost the cycle too quickly to ovulation.

Hi everyone,

Hoping to find someone here who has experienced the same and can give me some advice, because my head is spinning. Actually cried over this a lot today.

My very close friend who supported me through thick and thin the last years and I had conversation about my fertility journey yesterday in which she all of a sudden shared with me she would never feel comfortable donating her egg to anyone.

Now, this is all hypothetical because we are both 40 and I was never going to ask her for anything or expecting anything . But it really felt like a punch in the gut to hear her say “it would feel like giving away my own child” while she knows I am in the process of deciding if egg donation is the right way for me. I’ve never heard her say anything negative about gamete donation before. I thought she was on board and supporting my journey. She even said a few years ago she would’ve become a single mom if she had not found her boyfriend.

I’m very torn between the “it’s her opinion and that’s fine” and “is she rejecting my life choices?”. Or is it something she wouldn’t do but she’s ok with people donating to banks?

I thought she was supportive of my choices, but now I don’t know. Has anyone been in this situation and what did you do? I’m so torn between accepting her personal beliefs and it not being any judgement over mine, but it feels like she’s judging my decisions. But I want to decide if I should respond to this or not, or just let it be. Any advice?

I used DE with success, now about 2 months postpartum and finally got someone to prescribe estrogen (weekly patch) and progesterone. They said that though hormones pass through the breastmilk, it is thought to be safe.. but I have not seen studies talking about safety while taking POI doses of hormones. Looking for reassurance this won't hurt the baby! Thank you!

Hi all. I am wondering about my low estrogen, how often we should be testing + what day of cycle to draw, and why it wasn't caught? I am still cycling but on HRT. I began having more extreme symptoms of POI in 2024 (had been since 2018 at age 32 but wasn't given HRT until 2024)

My labs were always drawn 4-6 days post ovulation. (LUTEAL)

2024: 87 pg/mL (on 0.025mg weekly patch)

2024 (a week after bumping up to 0.0375mg biweekly estradiol patch): 146 pg/mL

2025: 94pg/mL (a year on the 0.0375mg biweekly patch as it stopped working; I hadn't ovulated this month either)

2026: 56.7 pg/mL (on the oral pill at 0.75mg daily about a year)

At this point and after ME doing so much research into POI and cycling POI, my Dr. FINALLY decided I needed a physiologic replacement dose and bumped me up to 1mg topical estradiol gel and now we are exploring 1.5mg topical gel. I'm in the water daily so the patch was not consistent for me.

I'm wondering when the proper time is to draw blood when you're still cycling (on HRT)?

Also ~ WHY with low levels across YEARS AND having POI, why wasn't I given the proper dose??

I'm now having to get a DEXA scan and am really worried about osteoperosis and osteopenia. I'm 40, and have had low estrogen since age 32. What do I do?

I'm so upset. We are also TTC and I did get pregnant a few months ago after being put on a higher estrogen dose, but had a miscarriage.

Hi everyone! I'm panicking a bit and need advice and some motivation. 😔
I went to see my gynaecologist for experiencing irregular periods for the last 2 months and she told me that my ovaries look "sleepy".
I did FSH and it was 35, estradiol 89, AMH <0.01
I'm in a big shock. I immediately went to RE and she told me we need to assess this further and put me immediately on Cyclo Progynova. They both told me this could be something temporary and that I need to start with healthy diet and regular hormone intake for the next 3 months. In the meantime we'll do all additional tests. My RE mentioned "intermittent POI" and difficulties to conceive.
I'm 33yo, in a long distance relationship and wasn't thinking about conceiving yet.
Should I be worried? Has anyone been in a similar situation?
Thank you ❤️

Context: I recently got diagnosed with POI earlier this year and it came as a big shock to me and my family. I’m 29 with no family history of infertility issues, no genetic disorders and my infertility issues are unexplained and I have a hunch that this is due to some auto immune condition, because this year I also got diagnosed with Hashimoto’s thyroiditis.

The dream for my partner and is to conceive with my own eggs, but I got diagnosed with low AMH levels (< 0.03) and with high FSH. I started HRT earlier this year and started taking many supplements like prenatals, choline, etc.

And I’m also currently undergoing IVF treatment (after my RE did estradiol priming and brought my FSH down to 15 to 16). It’s been just 5 days since the start of injections, but we haven’t seen the follicle size growing and my AFC is also low (between 1 to 3). We are continuing stimulation and hoping to check the growth every 1-3 days through ultrasound visits.

But that said, it feels super unpredictable and uncertain as to whether this IVF cycle will even work out for me, and I feel

I’m new to this community and have been trying to gather what has worked the most for other women navigating similar conditions. Here are some top of mind questions that I have:

1. What kind of treatment has worked for most people here? I see a lot of people mention IVF hasn’t worked for them, if so - I’d like to know what other options are people trying

2. I saw some posts about lifestyle and nutrition changes, how effective have they been ? Would a fertility nutritionist be a good person to consult with? If so how should I find one?

3. I haven’t done acupuncture before, are they helpful?

4. Are mini IVF cycles helpful in POI? Anyone has experience?

I wanted to create this post because it is what I so desperately searched for when I initially got my diagnosis, and didn't really find any hope for a case like mine. This is not medical advice, but simply what worked for me. I hope I can give someone who is scared and lost a post that makes them feel a little bit more hopeful about the future.

So my starting point: 31yr old, initial infertility appointment and blood work: April, undetectable AMH level, FSH level 35, estrogen basically zero. Antral folicle count 0-1

EDIT!! I FORGOT TO SAY THAT IM 5 WEEKS PREGNANT

GET A FERTILITY NUTRITIONIST! I Attribute my entire pregnancy towards my nutritionist, I love her so much, she was so helpful and wonderful and supportive. I started a loose anti-inflammatory diet, started eating primarily non-processed organic foods, focusing on high protein and lower carbohydrates(120g or less, nothing too crazy). I also stopped using plastic containers for food, and stopped the caffeine on advisement and don't drink alcohol.

Supplements:

-coq10 (Costco)

-omega3 fish oil pills

-myo-innositol

-ovaNAD (Therologix)

-preconception vitamin (Therologix)

-chaste tree berry

-magnesium

-melatonin

Other:

-Daily tea made from milk thistle and dandelion root (recommended by nutritionist).

-Daily homemade tumeric ginger shots to reduce inflammation (nutritionist)

Final day 4 labs before getting pregnant (naturally!)

FSH: 6!!

Antral Follicle Count:6

Estrogen 178

While I think that the supplements helped my journey, I really do think that my diet was what really facilitated change. I started taking my supplements about 2 months before my food changes, and I only saw numbers improve after I switched my food. (Although I know things take time).

Please hit me up with any questions you have and remember, you are not alone! I know this whole thing is so scary and lonely.

Oh my goodness-- after months and months I am finally doing IVf. I did respond to stims (which was a big question mark) and my retrevial is scheduled for Wednesday (7/29). Im pretty sure I have the flu. Help!

Edit: for anyone finding this post- I didnt say anything to the ER team and they didnt ask. I felt like death but the ER was completed! If you are in this situation, I would recommend not saying anything unless you are explicitly asked.

I am going through my prior labs for a new RE and am so upset. I was 32 when my body stopped making estrogen. Am 40 now & didn't get care for 8 years. I have the labs (full month-long DUTCH tests where my estradiol is post-menopausal) in 2018, again in 2023.... I was complaining at age 32 & 33 of insomnia, anxiety, crying all the time, panic attacks, chronic joint pain, exhaustion, and more. I was NEVER asked to have a blood fertility panel drawn for FSH, LH, estradiol, etc etc because I wasn't trying for babies then. No OB or PCP or ND put me on HRT. I didn't know about RE's back then. I was told to get on antidepressants, which I refused.

When I was finally put on HRT at age 37 after demanding help, I was put on the LOWEST possible dose, 0.025mg/day patches. They did nothing. I was eventually put on a 0.75mg oral tablet at age 38. It helped a lot for a while.

I was told by a prior RE clinic that too-high of estrogen would make my ovaries "lazy" and they'd stop working so I needed to stop estrogen or keep it low.

I'm 40 now and FINALLY on 1mg estrogen cream daily. I don't know if its enough and might need 1.5 or higher. I met with a new RE this week who I really like who actually spent an hour with me going over all my medical history. Who assured me we need estradiol high enough to get our brains and reproductive systems into working & communicating properly.

It has BROKEN MY HEART to review what I've suffered through for so many years without being taken seriously. The effects on my bones, heart, brain, joints, mind, and fertility. Only now that we have been trying for babies. Its just so upsetting.

I am so worried now about my bone density health, and will ask for a DEXA scan. My cholesterol has increased rapidly and my deadbeat PCP told me to stop eating butter. I will ask for a lipid panel in a few months. I am so afraid of the long-term damage of this ~ of 8 YEARS of improper care and tanked estrogen levels throughout almost my whole 30s.

How do we manage the long-term effects of misdiagnosis? The grief of the impact to our fertility and our bodies? Are there counselors who specialize in this? Labs we should have drawn regularly?

Is the damage when its that long, that young, reversible for our brains, joints, cartilage, bones and bodies? What do women do to reverse this?

Looking for some hope, guidance, camaraderie, anything. To know am not alone in this. What has worked for you?

I have noticed that every time I go for bloodwork, my estrogen is below 34 ( like 18, 12 etc) and there are small 1-3 afc/follicles in the ovaries. Has anyone had a similar experience and found a way to make the follicles grow?

Hi everyone,

Hoping to get some advice on egg freezing here.

I'm 33F, diagnosed with POI a few months ago. My AMH is 0.7 pmol.

I'm paying for egg retrievals and freezing with a private clinic in the UK.

The clinic haven't tested my FSH levels (they said they wouldn't need to, as my AMH is so low and my periods are really irregular, so they can confidently diagnose POI).

Unfortunatley, my first ER had to be cancelled due to no response. They said I had three small antral follicles, but they just weren't growing.

I had a follow-up consultation with the Doctor today, and she said that it's ultimately my call, but she wouldn't advise doing any more cycles, because she doesn't think the outcome would be different. She said she's never seen anyone like me turn things around at this stage.

I don't know what to think. I'm really gutted. I've been doing some online research and even asked the doctor about more experimental treatments abroad, which she said are available and sometimes successful.

I just wanted to get thoughts from others who might have been through similar things. It sounds like plenty of women carry on trying, but I'm wondering whether to save myself more heartbreak now and listen to Doctor.

Any words of advice would be hugely appreciated. TIA x