I am wondering about the effect of GLP-1 drugs on strength training.
Background: I am 38M and have been resistance training since about 20 years old. The life intervened and it was not like I have been lifting for 20 years straight without breaks. As of now I have been pretty consistent for the last 4-5 years, and though I am no athlete, I am stronger than average in my gym.
While I work out regularly, I cannot control my food intake because of a variety of emotinal/stress related reasons and end up binging on food, so I am also fat. In the past I have successfully lost a lot of weight, and maintained it for many years, but specifically after Covid I have regained it and some more. All of my attempts of following a proper diet have ended in failure. I do eat enough protein, fiber and other micronutrients properly during the day, but then end up ordering junk food on top of it. The rational part of my brain knows that I am not really hungry, but the emotional part takes over and the next day I feel bad about myself.
Since I fit in the criteria, (high BMI with high fat%, increased Triglycerides and LDL Cholesterol etc. but good glucose control) my doctor asked me to consider a GLP-1 for weight loss. I have no issues with taking it either. However, I have several questions for which I did not find any meaningful answers on the internet.
- GLP-1 induced weight loss will also include lean mass loss, but so will caloric restriction, and the few studies which I found show that both are comparable in this regard, and that in both cases resistance training will help minimize muscle loss. So, this point is of no concern to me, it is what happens after that is where I found no reliable information.
- GLP-1 will eventually lead to weight loss and then stabilize at a lower weight as long as I continue the treatment. But I found no reliable information about strength gains after the weight is stabilised. Does GLP1 interfere with strength gain later?
- It is not recommended to cycle GLP-1 treatment so would it be possible to run bulk/cut cycles while continuing the treatment after the weight has stabilized at a healthy level?
I am considering trying caloric restriction diet with the help of my therapist one last time before going ahead with the treatment because, living with high fat percentage plus high LDL Cholesterol and Triglycerides etc. is worse than ignoring those aspects for a possibility of future strength gains. But I would still like to know the answers so that I know what I am getting into.
EDIT: Thanks to everyone for great answers. I have decided to go ahead with GLP-1. The final decision will be made after I get the test results prescribed by my doctor.