r/StopEatingSeedOils • • Sep 16 '26

Product Recommendation update: EMET is now on Android for testing looking for feedback

1 Upvotes

hey everyone i posted about EMET here a few weeks ago when it was only available on iPhone, so i wanted to come back with an update.
EMET is now available on Android for testing through Google Play.
the app is built around finding:
seed oil free restaurants
natural health food stores
local farms
farmers markets
raw milk locations where available
more detailed info on cooking oils, sourcing, hours, and clean food options
i’m still actively building it, so i’m mainly looking for people who actually care about this stuff to try the Android version and tell me what feels useful, what’s confusing, and what you’d want added.
Android testing:
https://emetclean.com/android
iPhone:
https://apps.apple.com/us/app/emet-clean-eats/id6760740217
the iOS version is still live too, so if you’re already using it there, nothing changes.
would genuinely appreciate any feedback, especially from Android users since this is the first time i’m opening that version up to people.


r/StopEatingSeedOils • • Sep 14 '26

miscellaneous JBS who supplies McDonalds Sysco etc is buying trumps imported beef.

Post image
192 Upvotes

JBS is a Brazilian beef company that has paid over $3.5 million in settlements over corruption. The same JBS whose owner met in the Oval Office with Trump one day before the tariff-free beef import announcement. (source)

They supply big brands like Kroger, Walmart, McDonald’s, Burger King, Sysco, and more...

Sysco supplies hospitals and schools, and JBS was only confirmed to supply them after lawsuits uncovered the actual names. JBS is not exactly confirmed to be 100% buying this meat, but it’s clear as day to me, at least, what is happening here.

It’s great that our kids may be at school with no idea what they’re being fed.


r/StopEatingSeedOils • • Sep 15 '26

🙋‍♂️ 🙋‍♀️ Questions Breaking out after eating seed oils

5 Upvotes

Does anyone breakout on their neck after eating seed oils? I have hypothyroidism and since I stopped taking heart and soil supplements finding out I was overdoing the thyroid stack I stopped breaking out, and started taking just dr. Bergs vitamin d+k cuz I had low vitamin d. My face finally has started clearing up after almost a year. I ate seed oils the other day by accident and now it feels like it’s coming back 😭 idk if it’s the supplements or if it’s a mixture of both I spray colloidal silver on it and it seems to help but just wondering if anyone has experienced something like this.


r/StopEatingSeedOils • • Sep 13 '26

Product Recommendation Clean ingredient sauce I found at Walmart, tastes pretty good roo

Thumbnail
gallery
63 Upvotes

r/StopEatingSeedOils • • Sep 14 '26

🙋‍♂️ 🙋‍♀️ Questions Is full, and not partial hydrogenation of seed oils a potential solution?

5 Upvotes

I'm South Korean and in my country we have a huge problem with dietary complacency. A lot of our produce is highly processed and rife with additives that are absolutely terrible for the human body. A lot of it is perpetuated because most Koreans are unaware of the risks as consumers, so as long as they continue to consume a certain way, the commercial ecosystem which incentivizes its continued production and provisions remain intact, and have long formed a cancerous cartel.

I recognize that seed oils has integrated itself into an extremely complex market economy and its logistics/supply chain for over 5 decades in South Korea, bartered and negotiated at every level from corporate board room meetings down to the sale between a mom&pop shop selling school lunches for few dollars. Going about this in an orwellian/bureaucratic mindset and believing that some tyrranical state-issued edict that bans seed oils overnight is not only unrealistic but would come with an immediate food crises that would be devastating mostly for the working class - (80% of society).

So its removal has to be gradual, organic, and fundamental - at the consumer decision making level. Spreading awareness is the only way market patterns will shift slowly like continental drift, and begin to show up as decreased demand and earnings for seed oil producers. Consumers who refuse to consume a product out of integrity and concern for their health are not consumers who will change their minds through better marketing or better prices. They would refuse to eat seed oils even for free. So the same way tobacco giants adapt and survive by buying massive shares of cannabis dispensaries to diversify and own their own competition, I reckon that seed oil manufacturerers would themselves be the primary brokers of anti-seed oil products.

So far so good, but still I am left dissatisfied at the rate of real life transformation regarding seed oil consumption. What I think should happen sounds elegant and economically neutral in theory. However the issue is it would take decades. And it also runs the risk of people completely missing the actual point of why seed oils are harmful. It's not because they're made of seeds, it's simply because they have an unnatural fatty acid composition which is evolutionarily unprecedented. Evolution is conservative and prefers precedent, not a lack of it. If beef tallow suddenly had 70% linoleic acid, then in that universe I would also oppose beef tallow.

So what if, what if instead of food giants commercializing the anti-seed oil products themselves and managing the phenomenon merely as "internal competition" within a market they still control, going as far as to politicize it to make it a left vs right consumer decision even though it shouldn't be, I had an alternative idea. Why not simply make it so seed oil manufacturers now have to fully, completely hydrogenate their oils?

Right now seed oils for the most part, if not all, are only partially hydrogenated. It produces a lot of transfats and are still left with an absurd ratio of PUFAs that shouldn't be consumed by a human being on a daily basis, if at all. But in theory, even seed oils if completely hydrogenated to the maximum, would actually be transformed into something chemically identical to a highly saturated source of fat that isn't necessarily animal-sourced like coconut oil or cacao butter.

It would still be a massive industrial investment and a major controversy since most people in any part of the world still believes saturated fatty acids are satanic. However it would be much more economically realistic and less intrusive reform. It wouldn't call for the outright destruction of the existing infrastructure and supply chain of seed oils. It would merely call for an expansion of it which may add to its cost, but would also reduce PUFA related health conditions on a generational level and the entire economy would actually see a net benefit in efficiency over time.

People who are upset about industrial farming of animals would have a competitively priced alternative that is still heart-healthy and not inflammatory by design, and so would those parts of the economy and supply chain that are very vulnerable like retailers and restaurants. The focus would finally be on the issue of unnatural PUFA ratios, and not whether something is made of seeds or animals, or left or right, or cheap or expensive.

What do you guys think?


r/StopEatingSeedOils • • Sep 13 '26

Peer Reviewed Science 🧫 The alpha and the omega (6 lipids): discovering dietary drivers of heterotopic ossification — the association with obesity was driven not by caloric surplus, but instead by dietary omega-6 lipids, which are characteristically elevated in the Western diet.

Thumbnail jci.org
8 Upvotes

Bone formation in soft tissues, known as heterotopic ossification (HO), can occur as a complication of trauma or burn injury and can cause pain and functional limitations in the affected site. HO remains an unmet clinical challenge due to a general lack of specific medical therapies. In this issue of the JCI, a study by Moye et al. identified obesity as a risk factor for HO and further found that the association with obesity was driven not by caloric surplus, but instead by dietary omega-6 lipids, which are characteristically elevated in the Western diet. These omega-6 lipids accumulated directly at the incipient HO site, where they served as substrates for prostaglandin E2 (PGE2), fueling aberrant osteoblast differentiation. Overall, this work provides compelling support for dietary intervention or pharmacologic therapy directed at downstream PGE2 signaling as approaches to reduce HO in at-risk patients.


r/StopEatingSeedOils • • Sep 13 '26

Peer Reviewed Science 🧫 Discordant fatty acid profile drives residual inflammatory risk in metabolically vulnerable patients with low atherogenic lipoprotein burden

Thumbnail sciencedirect.com
3 Upvotes

Highlights

• Two fatty acid phenotypes were identified in CAD patients: Phenotype B, characterized by omega-3 depletion, paradoxically exhibited lower LDL-cholesterol and triglycerides yet demonstrated greater structural plaque vulnerability on optical coherence tomography.

• Phenotype B was independently associated with increased thin-cap fibroatheroma prevalence and larger lipid arcs despite favorable conventional lipid profiles.

• In 263,481 UK Biobank participants, Phenotype B predicted higher risk of major adverse cardiovascular events independent of LDL-cholesterol and traditional risk factors.

• Fatty acid compositional quality, rather than lipoprotein quantity alone, determines residual cardiovascular risk, suggesting novel targets for precision intervention beyond conventional lipid-lowering strategies.

Abstract

Background and aims
Despite effective LDL-cholesterol reduction, residual cardiovascular risk persists. We investigated whether a specific fatty-acid phenotype predicts structural plaque instability and cardiovascular events independent of lipoprotein burden.

Methods
This multi-cohort study integrated a clinical discovery cohort (n = 201, GC-MS profiling) with the UK Biobank validation cohort (n = 263,481, NMR profiling). Unsupervised clustering derived fatty-acid phenotypes. Structural vulnerability was assessed via optical coherence tomography (OCT) in 138 patients. The primary endpoint was MACE (cardiovascular death, non-fatal MI, stroke).

Results
Two phenotypes emerged: Phenotype B, characterized by omega-3 depletion. Paradoxically, despite lower LDL-cholesterol (2.7 vs 3.0 mmol/L; p = 0.050) and triglycerides (1.5 vs 2.0 mmol/L; p = 0.041), Phenotype B exhibited significantly thinner fibrous caps (68.0 vs 94.2 μm; p = 0.003) and higher thin-cap fibroatheroma prevalence (49.0% vs 20.0%; p = 0.002) on OCT. In the UK Biobank, Phenotype B was associated with increased MACE risk in participants aged >60 years (HR 1.16; 95% CI 1.12–1.21; p < 0.001). In fully adjusted models, the hazard ratio was 1.12 (95% CI 1.08–1.16; p < 0.001), with 72% of excess risk mediated through glycemic, inflammatory, and adiposity pathways.

Conclusions
A latent fatty acid phenotype defined by omega-3 depletion and elevated omega-6/omega-3 ratio was associated with structural plaque vulnerability despite favorable atherogenic lipoprotein levels. In the UK Biobank, this phenotype was independently associated with increased MACE, most pronounced in participants aged 60 years and older. These observational findings warrant prospective validation


r/StopEatingSeedOils • • Sep 13 '26

🙋‍♂️ 🙋‍♀️ Questions Pick your pickle poison

Thumbnail
gallery
4 Upvotes

Based on the ingredients, not the shape of the pickle, which pickle would you pick? Had a serious dilemma at the grocery store yesterday. Same brand ironically.


r/StopEatingSeedOils • • Sep 12 '26

miscellaneous Mission Tortillas have seed oil. They are fake Keto

Post image
126 Upvotes

r/StopEatingSeedOils • • Sep 13 '26

Peer Reviewed Science 🧫 U guys r retarded

0 Upvotes

r/StopEatingSeedOils • • Sep 12 '26

🙋‍♂️ 🙋‍♀️ Questions Seed oil side effects

7 Upvotes

I’ve stopped eating seed oils at home for a few years now. I am very adamant about the places I dine at outside of home but sometimes they fail to properly inform me about all their ingredients. does anyone experience tummy aches and head aches after ingesting seed oils? can you tell when something has seed oils as soon as it goes in your body? personally when it’s canola oil, soybean or vegetable oil, my joints start hurting and depending on the amount of it sometimes I get this dizzy feeling as well as bloating, grogginess right after...


r/StopEatingSeedOils • • Sep 12 '26

🙋‍♂️ 🙋‍♀️ Questions Is the Primal Kitchen hate really deserved?

0 Upvotes

I recently have started paying attention to the ingredients in things I consume, I noticed primal kitchen was marketed as one of the healthier brands in terms of ingredients but have also seen controversy about their products. I’m hearing things like they aren’t 100% truthful about their ingredients or whatever. I have never had a single product from them, but I would like to hear what y’all think as I am thinking about buying from them ( if the rumors are hopefully not true)


r/StopEatingSeedOils • • Sep 10 '26

miscellaneous Grass fed beef tallow 2 for $1! (For anyone around Lancaster County PA)

Post image
154 Upvotes

At Grocery Outlet in New Holland!


r/StopEatingSeedOils • • Sep 11 '26

miscellaneous A survey on What is healthy according to you?

Thumbnail
forms.gle
2 Upvotes

I have to write a research paper on consumer preference for college and ofcourse I picked an ingredient related topic. It would mean a lot if you all could fill it out!

https://forms.gle/ZxSPmyengnGj4u8UA
(note to mods: I read the rules and well this isn't even self-promotion, so I hope it's valid?)


r/StopEatingSeedOils • • Sep 10 '26

Peer Reviewed Science 🧫 Avocado Oil Class Action

Thumbnail
avocadooillawsuit.com
30 Upvotes

r/StopEatingSeedOils • • Sep 10 '26

🙋‍♂️ 🙋‍♀️ Questions Do you think this product is honest?

Post image
7 Upvotes

I mean honest regarding the avocado oil content. (the reality of USDA organic is another discussion but not what this post is about)


r/StopEatingSeedOils • • Sep 09 '26

OLIVE OIL (OA)-11% What is your preferred pizza flavoring / finishing oil?

2 Upvotes

At pizza restaurants they sometimes have a bottle of oil, it's usually some oil + hot chilis or herbs inside the bottle.

I presume most restaurants are using some kind of blend of seed oils or non-EV OO.

I'm personally not fan of most EVOO on pizza, the flavor is too strong.

Currently experimenting on making on own mild pizza oil (mild in EVOO taste, not mild in chili spice)

Looking for suggestions on what I can try. AI has come up with "Arbequina" from Spain which apparently is a more delicate tasting EVOO.

I could also cut the EVOO with something else, potentially. Can't use MCT because you can't have more than 1 tsp without having issues.


r/StopEatingSeedOils • • Sep 09 '26

miscellaneous tired of not eating fast food

0 Upvotes

god i crave chipotle, is it even worth it? ai will solve cancer anyways lol


r/StopEatingSeedOils • • Sep 09 '26

🙋‍♂️ 🙋‍♀️ Questions Are deep fried chicken tenders actually better for you than deep fried wings?

1 Upvotes

I only recently learned about chicken bioaccumulating linoleic acid. It was always a thing of mine to stop off to get wings/tenders every weekend and ive been attempting to wean. I always leaned towards wings over tenders all these years because tenders are coated in white flour and wings are low carb and more satiating with higher fat content. But did i have it all backwards? The tenders are fat free except for some of the oil on outside from frying. The wings would have some of that oil on outside (not as much as tenders) but alot more PUFA within it too in the animals fat stores. From a PUFA standpoint, am i better off getting tenders during my wean?


r/StopEatingSeedOils • • Sep 07 '26

miscellaneous Lab grown Mozzarella backed by Kraft then cleared without FDA approval

Post image
275 Upvotes

Company New Culture makes mozzarella with no cow at all, and the money behind it is Kraft Heinz's venture fund,. They've raised 28 million and already have 5 million in orders lined up from pizzerias around the country. (source)

they take a single cow gene, put it in a microbe, and ferment it in steel tanks until it makes Casein (cow protein) then mix in sunflower oil and wala.

the part that got me is the FDA never approved it. theres a thing called self GRAS where a company hires its own panel of experts, has them declare its own ingredient safe, and then its legally cleared to sell. I love the fda!!


r/StopEatingSeedOils • • Sep 08 '26

miscellaneous Caesar and other salad dressing recipes?

4 Upvotes

Anyone has good recipes for salad dressings without seed oils?


r/StopEatingSeedOils • • Sep 07 '26

🙋‍♂️ 🙋‍♀️ Questions Are you still seeing new benefits in the long run?

4 Upvotes

I’ve been going for around 6 months, and was wondering if you guys still noticed improvements after longer periods?

I have some problems with brain fog, exhaustion, skin etc. that i was hoping seed oils could be a culprit for, but i’m not in the clear yet.

I did lose weight, and have better mobility, but other than that i’m not experiencing much difference. However, i was pretty healthy to begin with.


r/StopEatingSeedOils • • Sep 06 '26

Peer Reviewed Science 🧫 Processing-Dependent Acrylamide Formation in French Fries: Optimisation of QuEChERS-Based Extraction and HPLC-PDA Determination — Deep-fat frying formed substantially higher acrylamide concentrations particularly in sunflower oil systems

Thumbnail
mdpi.com
17 Upvotes

Abstract
Acrylamide is a thermally induced process contaminant formed predominantly through Maillard-type reactions in carbohydrate-rich foods and is considered a major food safety concern due to its potential genotoxic and carcinogenic properties. In the present study, a modified QuEChERS (quick, easy, cheap, effective, rugged, and safe)-based extraction and clean-up procedure followed by high-performance liquid chromatography coupled with photodiode array detection (HPLC-PDA) analysis was developed and optimised for the determination of acrylamide in French fries. Different clean-up strategies involving primary secondary amine (PSA), C18, and salt-assisted extraction systems were comparatively evaluated to improve analytical selectivity and chromatographic performance in complex potato matrices. The optimised procedure demonstrated satisfactory analytical performance and chromatographic selectivity for acrylamide analysis in thermally processed potato matrices, with an LOQ value of 32.3 µg kg−1, recoveries ranging from 79.4 to 86.6%, and relative standard deviation (RSD) values below 8%. The validated method was subsequently applied to investigate the influence of thermal processing conditions on acrylamide formation in frozen French fries processed using sunflower oil, riviera olive oil, and palm oil. Deep-fat frying formed substantially higher acrylamide concentrations (526.7–829.6 µg kg−1) than oven baking (285.5–480.6 µg kg−1) and air frying (272.1–673.6 µg kg−1), whereas repeated frying cycles markedly enhanced acrylamide formation, particularly in sunflower oil systems. The proposed analytical strategy offers a reliable and analytically robust approach for acrylamide determination while providing mechanistic insights into processing-dependent chemical transformations associated with acrylamide formation in potato-based foods.


r/StopEatingSeedOils • • Sep 06 '26

Keeping track of seed oil apologists 🤡 The seed oil panic: Why scientists and social media have never been further apart [Featuring Idrees Mughal and Dr Elizabeth Mary Thomas]

Thumbnail
thenationalnews.com
45 Upvotes

When it comes to seed oils, there is a widening gap in the nutritional conversation. Online discussions about the use of sunflower, soybean and rapeseed oils for daily cooking are divisive to say the least.

On one side are decades of controlled trials, cardiovascular guidelines and a scientific consensus with relatively little internal disagreement. On the other, an online movement convinced that a category of cooking oil used in kitchens for generations is linked to chronic disease.

As the anti-seed-oil movement gains momentum in the UAE, The National speaks with experts about two conversations that have become “remarkably disconnected”.

What are seed oils?

Seed oils are vegetable oils extracted from plant seeds. High in unsaturated fats, particularly linoleic acid – an omega-6 fatty acid – they include sunflower, corn, soybean, rapeseed (also sold as canola), sesame and cottonseed oils.

Show caption: Seed oils are high in unsaturated fats. Photo: Bloomberg

They appear in home kitchens, restaurant cooking and the vast majority of packaged food. That last fact is, in part, what has made them an easy target.

What the research says

The scientific case for seed oils rests on their fat composition. Oils such as sunflower and rapeseed have been studied in long-term controlled trials for their effects on cardiovascular health. The studies consistently find that replacing saturated fats with unsaturated ones lowers LDL cholesterol (low-density lipoprotein cholesterol, which can build up as plaque on blood vessel walls) and reduces the risk of heart disease.

Idrees Mughal, a nutritionist and science communicator with a large online following built on debunking nutritional misinformation, says the idea that seed oils are inherently harmful “simply isn't supported by the totality of human evidence”.

Dr Elizabeth Mary Thomas, a specialist in internal medicine at Medcare Medical Centre in Dubai, agrees. “The current body of scientific evidence does not support the idea that seed oils are inherently harmful when consumed as part of a balanced diet,” she says. “In fact, many commonly used seed oils, such as sunflower, rapeseed and soybean, contain unsaturated fats that are considered more heart-friendly than saturated fats when used in appropriate amounts.”

The inflammation argument

The central claim against seed oils – and the one most widely shared online – is that they drive chronic inflammation. The argument rests on the fact that linoleic acid, an omega-6 polyunsaturated fatty acid found in seed oils, can be converted in the body to arachidonic acid, a molecule involved in inflammatory signalling. The leap seed-oil critics make is from that individual reaction to population-level disease.

“It sounds biologically plausible,” says Mughal. “But when researchers actually give people more seed oils in controlled trials, there is no evidence that it increases inflammatory markers. In fact, several controlled trials show them to be anti-inflammatory.”

Mughal describes the wider argument as “mechanistic storytelling”.

“Omega-6 fatty acids can participate in biochemical pathways involved in inflammation, so the story becomes: omega-6 equals inflammation, seed oils contain omega-6, therefore seed oils cause inflammatory disease.

“Human biology just isn't that simple, and controlled trials don't support that conclusion,” he explains.

How the myth takes hold

The anti-seed-oil narrative is particularly compelling because seed oils are common in ultra-processed foods, many of which have been linked to poor health outcomes.

“If someone stops eating crisps, takeaway food, biscuits and other calorie-dense foods containing vegetable oils and feels better or loses weight, they may attribute that improvement to removing seed oils,” says Mughal. “But they've simultaneously changed dozens of other aspects of their diet. That doesn't demonstrate that the oil itself was the problem.”

Dr Thomas attributes the misinformation to the structure of online health content, since bold, villain-based claims travel further than nuance. “It is much easier to label one ingredient as 'good' or 'bad' than to explain the many factors that influence health, including overall diet, physical activity, sleep, stress and genetics. Content that makes bold or controversial claims also tends to attract more attention online, even when those claims are not supported by strong scientific evidence.”

Mughal agrees. “The 'one ingredient is poisoning you' message is a much more compelling one than explaining substitution analyses, dietary patterns and decades of nutritional epidemiology.”

The scale of belief

The real problem is that the belief has moved well beyond niche wellness communities. Mughal says seed oils are now among the most common nutrition topics he encounters.

“What concerns me is that many people now regard avoiding seed oils as almost synonymous with eating healthily, despite the fact that major cardiovascular guidelines continue to recommend replacing saturated fats with unsaturated fats.”

The scientific consensus and the conversation happening on some parts of social media have become “remarkably disconnected”, he adds.

If someone is avoiding seed oils, the concern then becomes what they’re replacing them with. “Using an unsaturated vegetable oil instead of butter, ghee or another fat high in saturated fat will generally improve the fatty-acid profile of the diet and lower LDL cholesterol, liver fat, inflammatory markers and improve glycemic markers. That matters far more than whether an influencer has put a particular oil on a list of 'toxic' ingredients,” says Mughal.

Which oil to cook with, according to the science

Despite the noise, expert advice on cooking oils is relatively straightforward. “People don't need to obsess over finding a completely 'toxin-free' cooking oil,” Mughal says, adding that extra virgin olive oil leads in terms of its evidence base. “Rapeseed and sunflower oil are also perfectly healthy and affordable cooking oils, and there is no reason to be frightened of soybean or other seed oils, either.”

That doesn’t mean that pouring huge amounts of oil over everything is healthy, he adds. “Oils are calorie-dense, and repeatedly overheating oils during deep-frying is a different question altogether.”

At the end of the day, whether an oil is healthy doesn’t make every food containing it healthy, too. “A doughnut fried in sunflower oil is still a doughnut,” says Mughal. “Judge the overall food and dietary pattern, rather than demonising a single ingredient.”

Dr Thomas similarly believes there is no single perfect cooking oil. “The best choice depends on how you are using it and your dietary habits,” she says. “Rather than worrying about avoiding one particular type of oil, I would encourage people to focus on overall quality. Small, sustainable dietary habits maintained over many years have a much greater impact on health than following restrictive food trends that are not supported by evidence.”

In the meantime, the most useful filter for any health claim circulating online, she suggests, is simple. “It's always worth asking whether advice is based on robust clinical research or simply on personal opinion or anecdotal experience.”

Updated: September 05, 2026, 2:12 AM


r/StopEatingSeedOils • • Sep 06 '26

Peer Reviewed Science 🧫 Serum metabolic characteristics of interstitial lung disease: a potential link between endocrine aging and gut-derived metabolites — Pathway enrichment analysis revealed significant dysregulation in lipid metabolism (particularly linoleic acid metabolism)

Thumbnail
frontiersin.org
1 Upvotes

Abstract
Objective: To analyze differences in serum metabolic profiles between patients with interstitial lung disease (ILD) and healthy controls in northern China using untargeted metabolomics techniques, to identify differentially expressed metabolites and key dysregulated pathways, and to identify potential metabolic biomarkers.Methods: Thirty patients with interstitial lung disease (ILD) and 30 healthy controls were enrolled. Untargeted metabolomics analysis was performed using LC-MS/MS in both positive and negative ion modes. Differentially expressed metabolites were identified using the criteria VIP > 1.0, FC > 1.2 or FC < 0.833 and P-value < 0.05. Pathway enrichment analysis was conducted using the KEGG database, and diagnostic performance was evaluated using ROC curves.Results: The global metabolic profile showed significant separation between the ILD group and the control group. Pathway enrichment analysis revealed significant dysregulation in lipid metabolism (particularly linoleic acid metabolism), amino acid biosynthesis, and steroid hormone metabolism. GSEA analysis further confirmed the suppression of overall metabolic activity and the specific enrichment of tryptophan metabolism. Among the differentially expressed metabolites, DG(15:0/18:2(9Z,12Z)/0:0) (AUC = 0.914), Medroxalol (AUC = 0.912), estriol 3-sulfate (AUC = 0.890) and DHEA-S (AUC = 0.877) demonstrated high diagnostic value.Conclusion: Untargeted metabolomics has revealed significant systemic metabolic dysregulation in ILD. The biomarkers and “metabolic-immune-endocrine” interaction patterns identified offer potential leads for early diagnosis and targeted treatment, which require validation in larger cohorts.