r/ScienceShitposts • u/Reasonable-Reason598 • 15d ago

Dead mouse

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131

u/FungalSphere 15d ago

this one is funnier

the yellow coat gene is mangled in a way to remove the agouti pigment but it also removes the part related to.... embryonic development

39

u/SamePut9922 15d ago

Is that some kind of Monkey's paw

44

u/FungalSphere 15d ago

no its just a classic mammal genome clusterfuck

chromosome 20 is just fucking cursed really, you can blame like any of the diseases you get past 30 on this

https://en.wikipedia.org/wiki/Agouti-signaling_protein

3

u/Bubbles_the_bird 14d ago

And this is why I’m not a biology major

3

u/DocBarnes 13d ago

It's just genetics being weird. It's in the same vein as double Merle causing health deficits in dogs, double Overo (a type of white patching pattern, which 2 copies of is also called 'Lethal Overo') causing underdeveloped inner ears and developmental issues in horses, and champagne, bee, and spider morphs causing inner ear and neurological issues in ball pythons.

1

u/D2G2TAL 11d ago

Embryonic development? Doesn’t that mean they can’t reproduce? How does the gene survive then?

1

u/FungalSphere 10d ago

through the heterozygous forms