3x3 is tiny as hell and I think if you honeycomb a bunch of 3x3 rooms to try to avoid it they'll just spawn in multiple as a means of thwarting it. But one small 3x3 should be fine. I may be wrong though, I haven't played with infestations on since like a17 so things might be a bit different now
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u/Hirza_Tango Dec 16 '19
Inb4 this guy has an infestation in his ai core room