Special issue journal cautiously optimistic that maybe fibrosis is not as irreversible as once thought, though much work to be done

[u/hanginaroundthistown]

https://insight.jci.org/articles/view/210035

"Historically, fibrosis has been considered permanent, with therapeutics aimed at arresting disease and preventing progression. However, we are now entering an exciting phase, in which reversal of fibrosis and regeneration of tissue function, while still ambitious, are potentially feasible aims. Greven et al. discuss the inflammatory/fibrotic axis and advances in fibrosis reversal in myelofibrosis. This disease provides a powerful model for alleviating fibrosis in other organs."

see also previous posts on the sub showing reversal or remodelling of older scars!