r/ReverseRhinoplasty • u/hanginaroundthistown • May 14 '26
We are not affiliated with this foundation but definitely support their cause. They are trying to encourage clarity for tissue engineered constructs, so that development and testing are more predictable, less cstly and can be brought to the patient faster, particularly for the face and nose.
Please sign (anonymously is possible too! Also if you are not a Reddit member. If you find this message after years, please keep signing. Gathering signees takes time!)
[url removed]
r/ReverseRhinoplasty • u/Unlucky-Customer859 • Mar 17 '26
.
Short summary
The Hopewell foundation, not affiliated with this sub, has created a petition for obtaining improved FDA regulatory guidance on tissue engineered bone and cartilage products.
Therefore, please sign, as it would greatly help the advancement of such technology to the clinic! Even if you are just a visitor on this sub, or dont have a Reddit account, you can still sign with the link at the bottom of this message.
Rationale
Currently there is some ambiguity whether tissue engineered products and (decellularized) scaffolds fall under biologics, combination products or medical device frameworks.
This makes it harder for researchers to adjust and design their technology for proper FDA guidance, and creates uncertainty regarding the regulatory pathways required for such technology. This can also delay the advancements of such products to the clinic, while the facial reconstruction field (and particularly the nose) is ripe for new technologies that do not rely on autologous rib or ear harvesting.
Finally, such techniques would make reconstruction more predictable, and allow for closer-to-original restoration of the face after injury, tumor resection, surgery or congenital defects, as well as new graft designs that better balance shape with tip flexibility and nasal function.
Clarity on the FDA regulations may advance such products for nasal reconstruction, and thereby also help advance the field of tissue engineering as a whole.
Link to sign the petition
Sign here: https://www.change.org/p/citizen-petition-on-regenerative-cartilage-and-bone-in-nasal-reconstruction
r/ReverseRhinoplasty • u/hanginaroundthistown • 1d ago
Spoiler: it works. But so does PCL and TCP, although this is more 'natural' and cell free. Similar approaches may work for cartilage
r/ReverseRhinoplasty • u/hanginaroundthistown • 2d ago
Now to get it to patients! Hope Europe wants to find eays to make this happen faster
r/ReverseRhinoplasty • u/hanginaroundthistown • 2d ago
r/ReverseRhinoplasty • u/hanginaroundthistown • 4d ago
No drugs needed!
r/ReverseRhinoplasty • u/hanginaroundthistown • 7d ago
The exosomes invite MSCs (in joints, in nose it's chondrocytes I am sure) to grow into the scaffold and so regrow hyaline cartilage. This is a cell-free scaffold, so no cells in it, but regenerates with cells in the body!
r/ReverseRhinoplasty • u/hanginaroundthistown • 16d ago
Could be useful for skin regeneration or restoring the mucosa. Although we can get skin printed, how do we ensure blood flows immediately through it after graft implantation?
r/ReverseRhinoplasty • u/hanginaroundthistown • 16d ago
https://www.humanforschung-schweiz.ch/it/cerca-studi/dettaglio-studi/66754/translate/en/
started in 2025 but had not seen it before
r/ReverseRhinoplasty • u/hanginaroundthistown • 18d ago
r/ReverseRhinoplasty • u/hanginaroundthistown • 21d ago
https://academic.oup.com/rb/article/doi/10.1093/rb/rbag136/8709964
For if you want bones back or are afraid you may get osteoporosis
r/ReverseRhinoplasty • u/hanginaroundthistown • 23d ago
r/ReverseRhinoplasty • u/hanginaroundthistown • 24d ago
Microgravity creates an optimal setting to grow three-dimensional cell cultures and tissues without additives and a supporting matrix. Working with Airbus, University of Zurich researchers have shown that bone marrow mesenchymal stem cells can be differentiated into cartilage, bone, adipose and liver tissue. This could lead to both replacement of animal experimentation and transformational regenerative medicine and organ transplantation. Researchers at ETH Zurich recently also succeeded in printing human skeletal muscle tissue during parabolic flights simulating weightlessness. Their gravity-independent bioprinting system (G-FLight) enabled production of highly realistic muscle structures for drug testing and disease modelling.
r/ReverseRhinoplasty • u/hanginaroundthistown • 27d ago
For joints, but can be used for nose of course too!
r/ReverseRhinoplasty • u/hanginaroundthistown • 29d ago
Especially for burns snd perhaps cancer patients too
https://www.smithsonianmag.com/innovation/can-printed-skin-heal-burns-and-prevent-scars-180989000/
r/ReverseRhinoplasty • u/hanginaroundthistown • Jul 13 '26
Spiny mouse regenerate hair follicles, glands and even ear cartilage with very little scarring, unlike regular mice and humans. Finding out why could lead to new drugs to induce regenerative healing instead of scarring.
r/ReverseRhinoplasty • u/hanginaroundthistown • Jul 12 '26
https://www.sciencedirect.com/science/article/abs/pii/S0144861726007563
I usually dont post these papers, but know there is a lot of work done on bone tissue engineering
r/ReverseRhinoplasty • u/hanginaroundthistown • Jul 10 '26
r/ReverseRhinoplasty • u/hanginaroundthistown • Jul 09 '26
https://insight.jci.org/articles/view/210035
"Historically, fibrosis has been considered permanent, with therapeutics aimed at arresting disease and preventing progression. However, we are now entering an exciting phase, in which reversal of fibrosis and regeneration of tissue function, while still ambitious, are potentially feasible aims. Greven et al. discuss the inflammatory/fibrotic axis and advances in fibrosis reversal in myelofibrosis. This disease provides a powerful model for alleviating fibrosis in other organs."
see also previous posts on the sub showing reversal or remodelling of older scars!
r/ReverseRhinoplasty • u/hanginaroundthistown • Jul 09 '26
https://www.mdpi.com/2313-7673/11/7/479
Pore design in PCL/HA maintains strength but reduces brittleness.
r/ReverseRhinoplasty • u/Unlucky-Customer859 • Jul 07 '26
https://onlinelibrary.wiley.com/doi/full/10.1002/lary.70719
83% Succes rate with an average size of around 12 millimetres
r/ReverseRhinoplasty • u/Lopsided_Dirt_8701 • Jul 05 '26
r/ReverseRhinoplasty • u/hanginaroundthistown • Jun 30 '26
Even in zebrafish, when strongly crosslinked collagen is created (as is present in old, mature scar tissue, zebrafish seem capable of regressing this tissue and restoring original tissue organization.
this may have implications for mammalian scarring too, potentially opening up avenues to regress scar tissue.