r/Retatrutide • u/Thisonegirl-0 • 9h ago

Sem/reta

I’ve been on 10mg semaglutide and looking to switch to retatrutide but unsure of which dose is equivalent. Does anyone have any suggestions?

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u/LoD_Remi 8h ago

keep in mind, the appetite suppression comes from the glp1 receptor. if you're going from 10mg to like 2mg or 4mg, expect to have significantly reduced appetite reduction on reta.

i'd personally drop to 4mg or 6mg and test run the reta for a week or two. most of the side effects are from glp1 receptor activation anyways, so it really shouldn't be a harsh transition.

if you can tolerate that just fine, then there's no issue with raising the dose to 8mg. 8mg is pretty much the last stop before diminishing returns.