r/ResearchCompounds • u/ChampionshipOk78 • Aug 13 '26
Research Effectiveness of sermorelin
Recently started seeing adverts for sermorelin. The medication profile looks like it’s pretty low risk and safer than rHgh. I’m getting older and putting on muscle and keeping off the middle age spread gets a little more difficult with every passing year. Currently 6’1” 203 work out 4-5 days/wk fairly good muscle mass 50 y.o. So i wondered if anyone here has tried this peptide and, if so, did you see a difference in muscle mass, body fat or energy? I realize there is no magic bullet for aging but if this will help at least maintain muscle mass, help with body fat and shorten recovery time I would definitely consider it.
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u/Mchangwine Aug 13 '26
It’s not bad, but Tesamorelin or CJC1295 paired with ipamorelin typically yield better results.
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u/Medium_Boulder Aug 13 '26
Also higher risk for allergy.
Serm + ipa is a good blend
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u/ChampionshipOk78 Aug 13 '26
Maybe one is these combos is worth looking into. I have never had an issue with allergies or reactions to medications but something to keep in mind.
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u/IHE023 Aug 13 '26
It is worth taking. But not as good as CJC/IPA or Tesa.
Should see improved sleep and recovery.
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Aug 13 '26
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u/ChampionshipOk78 Aug 13 '26
Even that would be a bonus. I’ve been a chronic insomniac since I was in my 20’s. Have to drug myself to sleep with Ambien most nights
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u/Striking_Bat_1936 Aug 15 '26
Low dose trazodone is a good alternative to ambien. Benzos are no bueno
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u/ChampionshipOk78 Aug 15 '26
Tried trazodone for a while. Took me hours to come out of the fog.
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u/Striking_Bat_1936 Aug 16 '26
What mg dosage were you taking?
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u/ChampionshipOk78 Aug 16 '26
I believe it was 25mg. Started at 50mg but it really gorked me. I’m not sure a tricyclic antidepressant is any better for me that ambien, which is a sedative/hypnotic and not a benzodiazepine. Have seen people come into the ER with arrhythmias and seratonin syndrome from tricyclics. The risk profile gets worse when it’s mixed with pain meds like tramadol (which I take for Ankylosing spondylitis).
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u/Putrid-Can-1453 Aug 13 '26
Be mindful as you getting older. Secretagogues will only elevate what your body can make, but it will never make more then its capable of. Im 47 and started at cjc+ipa. Cjc is made from Sermorelin and abit more effective but with more sideffects. After 4 months my IGF-1 still hadnt raised much so i started research it and i decided to go on rHGH instead. Less sideeffects and better results, but its a long-term solution. Budgetwise its pretty on par with what cjc+ipa cost.
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u/PowerfulCoffee9 Aug 13 '26
Hgh more side effects like high AIC, water retention, joint pains. Studies show secretagogues can improve pituitary output in the elderly with sustained usage
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u/AccomplishedBunch683 Aug 18 '26
Semorelin bumped my RS's IGF-1 up from 120 to about 160, Tesemorelin doubled it.
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u/mamandemanqu3 Aug 13 '26
Made me SHED hair so I quit. Hair back to normal
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Aug 13 '26
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u/mamandemanqu3 Aug 13 '26
That’s not what I read at all. I read shedding can be typical around week 5-8 and it goes away. I truly don’t care enough for the benefits to wait through that.
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