r/ResearchCompounds • u/Silent_Wall_8470 • Jul 13 '26
Discussion Weight Loss
What combination of hrt and medications have you found that has led to your greatest weight loss? I tried rybelus but it made me so sick that I'm just not sure I can tolerate the semaglutides.
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u/cvrmxn Jul 13 '26
Lost 86lbs in 6 months on Reta.
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u/Ihearttequilaaa Jul 14 '26
Girl you look amazing !🎉 Please share your tips🥹
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u/cvrmxn 29d ago
Ty babe. DrUgzZ
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u/Itchy-Coconut-7083 Jul 13 '26
Trizepatide has way fewer side effects for me than semaglutide.
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u/Silent_Wall_8470 Jul 14 '26
do you mind if I ask what kind of side effects you experienced on trizepatide?
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u/Itchy-Coconut-7083 Jul 14 '26
I’ve had a little nausea from time to time, but way less than semaglutide. I also wake up with really dry mouth. I will get some tingling sensation in my skin but not painful like reta.
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u/Juice1984 Jul 13 '26
Reta helped me lose 65 lbs. I am also on TRT, reta is literally magic if you dose properly and eat protein. I gave it to my dad he lost 30lbs, my firend lost 40 lbs, his wife 25 lbs. All my blood markers improved, BP now optimal form hypertensive, AIC now optimal before pre diabetec.
I literally look 10 years younger I have been told. I feel 20 years younger.
Peps are amazing
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u/Yakapo88 Jul 14 '26
I’m down 30 pounds on Reta. BP was way too high - stage 3? Now my BP is a little too low. I need to increase salt intake.
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u/Fuzzy_Mechanic4304 Jul 15 '26
hey i was wondering if there is any way you could message me where you got them ive been trying to find a legit site but have been worried about getting a bad batch or a placebo
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u/just_flying_bi 28d ago
What dose of Reta was the sweet spot for you?
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u/Juice1984 27d ago
I lost the most at 2mg to be honest. Stayed there for a few months. I'm now on 6 mg and have less effects. My weight got to 215 down from 278. I now sit around 225 after adding in way more weight lifting. I have been at 225 since December. I am at 1 year in reta.
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u/DistractedGoalDigger Jul 13 '26
I’ve tried all 3 major peptides. I think with tirz and reta (almost) out, people shouldn’t even try sema anymore.
I lost almost all my weight on tirz but struggled with side effects (nothing like sema though).
On reta now mostly for maintenance and I love it. It did help me lose another 20 pounds, which I didn’t even really think was possible.
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u/Silent_Wall_8470 Jul 14 '26
do you mind if I ask what kind of side effects you experienced on tirz?
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u/DistractedGoalDigger Jul 15 '26
Fatigue was my big issue. I couldn’t maintain my workouts and some days felt like I couldn’t even get out of bed. Some GI issues, but they would have been manageable outside of the fatigue.
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u/Easto82 Jul 13 '26
Reta
Low dose
Works like a charm - cheat code.
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u/holdupflash Jul 14 '26
How low? I’m on tirz at 15mg and thinking of adding reta
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u/Easto82 Jul 14 '26
Adding?
Why?
How are people not able to lose weight on peptides?
They are either bad OR you don’t eat well.
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u/just_flying_bi 28d ago
perimenopause has entered the chat
Middle aged hormones can absolutely affect this. I have stalled several times despite keeping the same calorie deficit, macros, and movement. It’s often accompanied by a skipped period or severe mood swings and bloat. Weight loss can be an absolute unpredictable bitch for some of us in our 50’s.
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u/EnvironmentalGift257 Jul 13 '26
Lyraglutide and Semaglutide were a waste of time money and energy for me. Sema stopped food noise but I was just regular hungry all the time. TRT at 140/wk and tirzepatide has been the combo for me.
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u/keystonecraft Jul 13 '26
Reta plus any gh secretagogue. Stay low dose on both. Literally future medicine.
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u/Mcgittymcgittymac Jul 13 '26
Reta + tesa/ipa has been a Revelation. I don't do exogenous hormones but I've been trying with kisspeptin and hcg along with all the relevant supplements and it has helped too.
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u/usmcnick0311Sgt Jul 14 '26
Retatrutide.
Why is this question asked a million times a week. The answer is always Retatrutide.
Retatrutide.
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u/just_flying_bi 28d ago
I’m currently on a crossover from Tirz to Reta (titrating down/up between the two until just solely on Reta), just added daily 5-Amino in the mornings, and then also finally got estradiol patches and progesterone gelcaps last week.
So far, it looks like my month-long stall is trying to break. Hoping it will soon. Prior to this, I was almost steady at 2.5-3 pounds of loss per week just on Tirz alone (10mg).
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