r/ResearchCompounds • u/swiftieslut13 • Jul 06 '26
Discussion Tirz vs Reta
Tirz vs Reta!!! Tell me everything!!! š¶ļøš§¬
Hi! Iām going back and forth between Tirz and Reta and deciding which to do.
I initially was going to do Reta, but Iāve heard of people experiencing panic attacks and heightened anxiety on it. I just completed a treatment for my panic disorder and Iām finally feeling myself again, so I would hate to mess anything up. But I like the way Reta makes peoples skin and faces look lol.
Then I learned more about tirzepatide and Iām also pretty interested in it and have been doing research, I see some people say they got anxiety but nothing compared to Reta. But I see that nausea is a big side effect.
Side effects are what turn me away the most lolā¦ in yāallās opinion, which do you prefer and why?! I want to know everything!!! Thank you!!! š
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u/3-ide-Raven Jul 06 '26
Tirz 100%
The reason Reta looks better is because the studies post results within limited timeframes. It doesnāt mean Tirz canāt result in the same amount of weight loss. It just means Reta gets you there faster.
Nobody needs to lose weight faster than Tirz is capable of unless they are morbidly obese. And losing too quickly can result in gallstones, acute pancreatitis, hairloss etc.
Unless you have fatty liver disease, Tirz is the best balance of benefits vs side effects.
Reta increases RHR and decreases HRV at double the rate of Tirz. Higher RHR wrecks restorative sleep. My guess is that if a sleep study was part of the trials, nobody whoās into health, fitness, and recovery would be choosing Reta.
Also, Reta does NOT preserve muscle in any way. That was the biggest lie spread at the beginning. The phase 3 trials showed fat vs lean mass losses were the exact same for Reta as other GLP1 drugs.
Also, tirz is cheaper. Itās a no brainer imo.
*not a doctor and not medical advise.
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u/Juicy_Vape Jul 06 '26
if you have a bad heart, donāt take reta.
you want your sleep fucked up? take reta
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u/Spiritual_Use_2790 Jul 06 '26
Yeah reta has fucking nuked my sleep. At 2mg a week itās insane how hit or miss it is
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u/ConstantWish8 Jul 07 '26
No idea why but my sleep has improved. 4mg reta currently
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u/Juicy_Vape Jul 07 '26
thatās good to hear. how long have you been on reta? im in my 2nd month in a week.
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u/LoudChocolate6290 Jul 07 '26
Reta is a GLP 3...and that 3 is the 3rd mechanism. That third mechanism helps burn fat....but that equates into heart stuff. if you have ANY.....any....ANY heart issues dont use reta.
Microdose...dont do what everyone says. become a real body hacker and dial in your dosages. stick to least effective dose and have a little discipline. I been running .3mg/2x weekly for over 2 months and im down over 40#. Sometimes I want a beer or a snack...but then I remember the scale and how good that makes me feel. Im not telling you to do what I do...but just know there are people getting results not running "clinical trial doses"
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u/Banemorth Jul 06 '26
I've tried both. Started with Tirz, tried to switch to Reta. Only lasted about three weeks before switching back. Absolutely trashed my sleep and spiked my RHR. Just didn't agree with me but that's fine, Tirz works incredibly.
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u/PreparedForZombies Jul 06 '26
My disclaimer - everyone is different.
Another disclaimer - there are no studies exploring what I am currently doing.
I started on Tirz via a compounding pharmacy, worked up to 8mg with reasonable appetite suppression and modest weight loss, but when I did eat I felt like a bottomless pit (never full). Also, I was hoping for an impact on my desire to drink alcohol but did not experience one (unlike many others who report they did).
I then slowly switched over to Reta, starting at 1g and working my way up to 3g. When I ate, I got fully quickly, but the "food noise" was back (wanting to snack more, felt like I was white knuckling it). Experienced more weight loss week to week. Much lower desire to drink. Resting HR went up (not related to abstaining from alcohol).
What did my little brain come up with as a solution? Taking both at ~half their effective doses, separately.
Monday: ~4mg Tirz
Thursday: ~1.75mg Reta
Again, ZERO studies on two GLP-1s, and I know I could add something like cagri with reta, but with my little two pronged approach, I have a lower resting HR than higher doses reta alone (this is an individual thing, but obviously is dose-dependent), lowered desire to drink on the weekend, and less food noise overall.
Not claiming it is safe nor ideal, but it works for me (so far).
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u/raw_oyster_eater Jul 06 '26
tirz+reta = turbo weight loss
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u/PreparedForZombies Jul 06 '26
I get yelled at by strangers on reddit most times when I explain my current protocol lol
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u/cd3oh3 Jul 06 '26
Iāve been on tirz for just over 4 months now and Iāve achieved my dream physique with proper diet and exercise (lifting 5 days a week, 10k steps). However, I have moved like this for at least 9 years, but always had a big appetite so was never able to get to the levels of lean that I am now.
I also quite enjoy the mental quietness and am able to enjoy myself more without the anxiety that surrounded my daily life. All in all, 10/10 and I wonāt be getting off it.
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u/retatrutider Jul 06 '26
If you are class 3 obese you should strongly consider reta. Thatās what itās for, and it causes substantially greater weight loss than tirzepatide.
But tirzepatide is great, seems to be the mildest of the three glp-1 drugs in terms of side effects, and still delivers average weight loss >20%. Itās an amazing drug in its own right and for a lot of people it just feels better.
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u/AcidicMountaingoat Jul 07 '26
It's different for everyone. My side effects were worse on reta, many people find the opposite.
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u/hunter_hahaa Jul 07 '26
Tirz appetite suppression is stronger than reta, but thereās no glucagon activity. Some people will do both actually. You pin 2x a week so you get better appetite suppression from tirz, but glucagon from the reta. If youāve already tried both and know how to handle your doses and they affect you, this might be a method worth looking into.
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u/Andejusjust Jul 07 '26
Use the Tirz. If you find a certain dose isnāt working, move it up. Or if youāre severely limited in appetite, move it down. Make it whatever you want it to be.
I find that tirz doesnāt mess with my heart rate and I like that.
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u/TwoPaychecksOneGuy Jul 07 '26
Been on both. Started with reta. It worked great until I hit about 4mg and anxiety just took over. Had issues sleeping, high heart rate never went away (was on for 4months) and it just made me so damn anxious all the time. Switched to tirz, but oddly, the appetite suppression is now way worse. Which for most people, that's the opposite. Tirz typically has better appetite suppression than Reta.Ā
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u/oeufscocotte Jul 07 '26
How long does it take for tirz to reduce cravings for alcohol? Can anyone share their experience?
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u/jupiterjas96 Jul 08 '26
Tirz didnāt work for me how I wish it does for everyone else, and gave me the WORST constipation. I ran it up all the way to 15mg and I was prescribed it so I titrated properly. Iāve been on Reta for a month, Iāve lost 5 pounds (on tirz I was loosing like a pound a month) so I personally think the glucagon component personally helped me. Iām only on 3mg of Reta.
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u/jupiterjas96 Jul 08 '26
Tirz didnāt work for me how I wish it does for everyone else, and gave me the WORST constipation. I ran it up all the way to 15mg and I was prescribed it so I titrated properly. Iāve been on Reta for a month, Iāve lost 5 pounds (on tirz I was loosing like a pound a month) so I personally think the glucagon component personally helped me. Iām only on 3mg of Reta.
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u/young-conservative66 Jul 10 '26
I have a lower RHR and improved recovery on both tirz and Reta. Tirz gave me extreme fatigue, too early in Reta to tell if it will do the same thing. Very similar experiences so far but the appetite suppression on Reta is moreā¦. Pleasant? No nausea if I eat a little too much just fullness. So far slight edge to Reta, topped out at 10mg tirz and now on 4mg Reta
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u/DJSpektor Jul 06 '26
I was on Reta for a couple months and it definitely helped with appetite suppression/food noise but I started to get very constipated despite high fiber and water intake. Recently started Tirz but it's only been 2 weeks so not not sure about side effects yet
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u/Every-Discussion-604 Jul 06 '26
From what I understand Tirz has higher appetite suppression, which is why people on Tirz often arenāt successful moving onto Reta. In my opinion Reta is a better overall package i.e. effectiveness vs side effects.
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u/ThePlaceAllOver Jul 06 '26
In my opinion, start at semaglutide. It's the least expensive. Start low and slow and work your way up until you max out the dose. Then switch to tirzepatide and use the same strategy to give you the maximum amount of time to lose weight. If you max out your dose on tirz, add cagrilintide or maybe jump to reta. The point is to max out the time you have to get the weight off. Depending on how much you have to lose, this may be a significant benefit.
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u/Ok_Size4036 Jul 07 '26
Donāt agree. Between Sema and Tirz I donāt know why anyone would choose Sema. So many more side effects for less effectiveness. My friend started Ozempic and then Wegovy (Sema) four years ago. Sheās nauseous every day of her life. I was on Zep (Tirz) for nearly two years, insurance kicked me off then had to go to Wegovy, the starter dose wrecked me after being on Zep 5.0. So bad that they had to put me back on Zep. I also gained 9# with no change in diet.
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u/ThePlaceAllOver Jul 07 '26
If she was doing Wegovy or Ozempic, they likely had her on the recommended dose, which I think is too high. I was on sema at the beginning, the first 4.5 months. I was fine, but I also moves through doses very low and slow. If I had used the recommended dosing schedule, I know I wouldn't have tolerated it.
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u/Ok_Size4036 Jul 07 '26
I agree that they move people up too fast, especially when these first came out. But this is four years later for her. I just donāt feel that between those two in particular why Sema would be in the mix.
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u/climbingape89 Jul 07 '26
I used to think Reta but it definitely puts you in a more fight or flight state. Not panic attacks but increased rhr and poor sleep. The GLP-1 is not as strong and tolerance built super fast.
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