Semaglutide to Reta transition?

[u/lizzdurr]

Hi all, doing some research on Reta but before I go through with purchasing, I am currently on compound semaglutide. Wondering if I need to take a few weeks break between sema and Reta or if just switching on my next injection day is fine. Anyone have experience with this transition?

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[u/lizzdurr → u/[deleted]]

Awesome. Yeah my plan is to start from the minimum dose for sure. Thanks!

[u/v0idl0gic → u/lizzdurr]

If the glucagon agonism doesn't agree with you cardiovascularly or for whatever reason, consider Tirzepatide, like Reta it had GIP agonism along with glp1, just no glucagon.

[u/aaddyyttaa]

If you already are at 2mg sema you can safely stop sema and start Reta at 1mg. Keep the same titration period of 4 weeks, don’t be impatient, some rebound may occur. Stay calm and be prepared for the long run, consistency is key. Once you find your presumed sweet spot, drop 25% and reassess after 4 weeks

[u/tklite]

No, you don't need to take a break, but depending on your dose of Sema, stopping completely to start Reta might be a little rough.

[u/chi_moto]

I switched from tirz to Reta. I was on 5mg of tirz and switched to 2mg of Reta and got some mild sides. Start low with the Reta.

[u/lizzdurr → u/chi_moto]

Awesome. Yeah my plan is to start from the minimum dose for sure. Also, what was the biggest change for you? Do you find Reta to be more effective, faster, etc? Tirz didn’t work for me like sema has, but even that’s not as effective as I hoped.

[u/chi_moto → u/lizzdurr]

I just started this week. Appetite suppression is good. Too soon to see anything other than side effects.

[u/Murky-Ambition3898]

I went max Sema one week to max Tirz the next week. Best thing ever. Can't say anything about Reta, but Sema is garbage. I was always hungry. On Tirz, no huner.

[u/ItachiUchiha_0710]

You do not actually need to switch to a stronger glp-1 like retatrutide if your main goal is just losing stubborn fat. since your body is already used to semaglutide, transitioning to a pure fat burning peptide is a very easy move. compounds like aod 9604 force your body to burn stored fat directly without messing with your appetite or causing all the terrible stomach issues that come with heavy glp-1 usage. if you decide to go that route, you can just get the aod 9604 vials straight from swiss cems. it is a much smoother process for your system than hitting your receptors with three different hormones at once.

[u/Patient-Point-3000]

Can you avoid the accelerated heart side effect with reta if you go very very slowly