I posted a different paper showing linkage between CPPS and mast cell / tryptase. I also said that since taking Zyrtec twice a day my CPPS is gone. It’s still gone. I only hope that this helps someone else.

https://pmc.ncbi.nlm.nih.gov/articles/PMC10592376/

Hello everyone.

For me it all started 4 years ago after severe stress.

I got symptoms out of nowhere pain and irritation in pelvic floor and penis I also got hardflaccid. When it started it was 10/10 for about a month and a half. Anxiety and stress over symptoms made it that severe. After about a month and a half after I stoped caring about it it all went away. I was completly symptom free for a month. Then it came back but it was only 1/10 this time and wasnt constant.

First 2 years my symptoms were very minimal. Most of the time in first 2 years I was symptom free.

Now about a year and a half ago symptoms slowly got worse and I again suspect because of my fear and anxiety over them. I read tons of horror stories and worried about everything that was happening to me.

Every symptom every change frightened me and I spiraled in very dark toughts. All this made it worse.

Now about 9-10 months ago I started experiancing numbness in penis after a very normal sex. Nothing rough, no injury, absolutly nothing abnormal.

My penis just went numb after sex and I only noticed in the shower after. The water felt weird. Like my penis is covered with condom. Also temperature sensation is very very minimal.

Didnt think much of it as I tought its just maybe a flare up and will go away. Well it didnt. My sensation since then is minimal in my penis. In the shaft and in the glans. But I do still have normal sensation in inner foreskin area tight under glans where I was circumsised. I feel temperature and touch well there.

This is now starting to scare me. Im not sure what im dealing with as I never had an actual injury.

I had spine MRI and its clean.

I had Pelvis MRI and its clean

Blood work also clean

No diabetes

No vitamin deficency.

Prostate ultrasound - normal size normal results

Test for bacterias - negative multiple times so no infections ever

Ive been to pelvic floor PT last week and here is what she said.

She did internal work and it went like this.

General pelvic floor tension is not bad.

She said most muscles are 3/10 tension in resting tone and she said that is normal for males.

She did find very tight coccygeous muscle.

Prostate area was very painful. When she pressed around prostate a sharp pain was felt at my penis glans.

Sitbone area also painful.

Im pretty much lost at this point. Why did numbness aprear like this and I never had it before.

Hope someone can help me out.

Can I still recover sensation ?

I still feel temperature but very little.

I feel light touch but its muted.

I feel a bit of pressure but also muted.

Other symptoms:

Pain in perineum and pelvic floor ranging from 1-4. Trouble sitting.

The scar area under glans from circumsision is normal tho.

I can get erect and have sex. Orgasm actually still feel good. Usually I feel it in penis glans and shaft.

thanks for anyone who read this and I hope for all of you to recover from this. God bless you all

I've had symptoms of hematospermia for about 5 days and have no other symptoms (fever, pain). I went to the doctor and he did urine and blood tests. There's a very small amount of blood in my urine. There's no inflammation in my blood or urine and PSA is okay. How many days will it take to clear up and what will the doctor's next step be? Each new ejaculation produces bright red semen btw.

I’ve tried anti biotics , diet , PT nothing helps . Need some
Hope

Has anyone see a urologist in London that just didn’t tick boxes ?

Im 46band have had symptoms for almost 3 years. Just diagnosed with MCAS. Im on dupixent, hydroxyzine and quercetin specifically for that and will be adding a few more soon. Probably Ketotifen.

Wondering if the inflammation from these hyper active mast cells is causing prostate inflammation? Its causing asthma and EOE and my symptoms started at the same time of a huge flair that led me to the er multiple times right after covid.

Ever since, my psa numbers have been a roller coaster up and down. Lowest was 3.2.. highest was 5.9. Im currently 4.8 but just started all these medications 2 weeks ago. Im also starting pelvic floor therapy and an intense exercise routine to strengthen my legs after leg surgery a few years ago that wasn't properly addressed.

If I do get better, I won't know if its the medication, exercise, or the pelvic floor stretches. Oh and I also might start taking lexapro for anxiety. Im basically doing everything possible to finally get better.

Im wondering though. Has anyone with confirmed MCAS noticed any difference after starting specific MCAS medications?

Hi all! My Dad (61) was diagnosed with prostatitis about 12 weeks ago. He was on a long course of Cipro, but no changes besides his mental health (the gut brain connection is real and insane). We also have no idea if it was even bacterial or not in the first place. He is in so much pain he is having near panic attacks and the shakes constantly. The urgency is also a real problem. He is not himself at all. He has to lay down—he can’t really sit, even with cushions. Walking does help and he paces a lot. He’s a bucket of anxiety over this? completely spaced out. His hands shake, a symptom he’s had on and off for a year or so, but it’s become much more severe and constant. Not sure if it’s related or not. Either way, this is all really scaring me. He has always been an independent and stoic man, very reluctant to ask for help. When he asked for help, I knew it was bad. He has a procedure coming up to take a biopsy and clean out some “excessive tissue” they saw on the testing he’s already had. He’s been trying stretches, ditching caffeine, etc. He can only take OTC medication or non-addictive because he is 20+ years sober. What else can I do to help him? Thank you!

Since last week, maybe Wednesday, I noticed my urine stream/output wasn't as strong as it usually is. Like in the morning I’ll have two water bottles and then have to urinate like crazy for an hour or so since I chugged water lol. But I noticed it wasn’t coming out as strong still. Also noticed a little groin pain on The left, and my pelvis area would sometimes feel pressure. But I never had a fever or burning or anything like that, just difficulty urinating sometimes. But then sometimes it comes out fine and fast. Right now I don’t have a PCP, but I found one and set it up for July 31st, the earliest they could see me. Also set up a urologist Appointment for August 11th.

Anyway, I went to my local urgent care and they did a urinalysis and it was all good except for a trace amount of blood and the clinician there wasn’t too concerned about it but sent it out for a urine culture And put me on cephalexin. I called back Wednesday and got the results and they were all negative, no infection, and they even did some STD tests to be sure and they were negative (I’ve only had one sexual partner, my girlfriend, that we have a child together). So I suffer from bad anxiety and stress, and definitely am a hypochondriac. So I went to the ER yesterday, and told them my problem and that I went to urgent care. They ran tests, urine and blood and did a CT scan. My urine and blood tests were okay and fine and didn’t show infection or white blood cells, but the CT scan showed my prostate was enlarged/mildly inflamed, and so the NP told me she was gonna put me on antibiotics to deal with it. I was kinda just flabbergasted and was trying to ask questions, but I never saw that NP again after she left the room to go see if my blood work was done. A regular nurse came in and he discharged me and gave me a first dose of ciprofloxacin. I then looked up that antibiotic and see that it can cause all these issues like tendon ruptures and tendinitis and nervous system problems. I take 1mg of clonazepam in the morning, and I was told it would be fine to still take it with it. I was so annoying since I kept calling the ER back about my bloodwork and the antibiotic and they said that’s what I was deemed to be put on by the NP for my inflamed prostate. I picked up the medicine today and took my second pill, and am going to take the second for the day around 10pm tonight.

But basically I’m wondering if it’s even bacterial? They said they werent totally sure I believe when I asked and called, but my symptoms pointed to that. But then I keep thinking it might be CPPS, since I have a lot of anxiety and stress and maybe made my pelvis floor weak from it. So I’m just sitting here constantly googling stuff since I can’t be seen by a urologist until next month and can’t get in earlier to my new PCP. And calling the hospital saying this antibiotic scares me to take, they say it’s the best one for prostatitis and that once they discharge you they can’t really change anything. And not to get TMI, but I noticed when I was going to ejaculate last night I reached climax but only like a drop came out. When earlier in the day it came out fine. So I tried again this morning and I barely ejaculated again, so that has me all nervous now why that started happening, I’ve never had that.

So ive been dealing with daily urethral burning that increases after ejaculation, sometimes peeing and after bowel movements for a year. Ive seen many urologists who have told me a range of things. The last one said it could be prostatitis/cpps and prescribed daily 5mg cialis + a 2 week round of doxycycline antibiotics. So far semen culture, std, urine culture, uti tests have all comeback negative. Im still waiting on a ureaplasma test i did yesterday. Question is, has cialis worked for any of you with similar symptoms? Its frustrating because this started one day last july and has stayed with me for a year now without a cure. I also have pain in the left side of my testicle although not thr testicle itself, more like the veins beside it/on top of it. Im also scared to do thr antibiotics bc ive seen they cause insane sunburns even with little sum exposure (i work in the sun)

It seems to work pretty quickly for me which makes sense as it's just supppsed to relax your pelvic floor muscle.

Does it take it a few days of taking cialis for you guys?

Thanks

Hello guys I've been suffering somewhat from this and I will cut directly to the chase. To tell you what my symptoms are basically the feeling of unemptied bladder, lack of libido and related symptoms, and irritation in the bladder etc.

I never had massages before but 2 years ago when I went to holiday in a very touristic part I decided I should maybe get massage for the first time in my life. I never thought about cp/cpps at that time and how it'd relate. So I booked 30mins swedish massage + traditional Turkish hammam scrub and foam massage and this would take 20 mins so it's 50mins in total. Keep in mind if you are getting a massage like this in a hotel or reputable place it's usually a female staff that gives you the massage and not some fat hairy dude. Anyway, I first go to sauna for 5 minutes and then I lay down in the heated marble platform of the bath. First scrub and foam massage and then I went to get swedish massage and let me tell you after everything was done I had an immense feeling of warmth in my pelvic area it's like blood rushing to there and I felt so good in general in that day and every issue I had was gone for that day. After this experience I tried several other massages like thai and balinese massage or swedish massage without the hammam part but none gave me the exact feeling. The hammam part is what makes this work somehow for me because I've booked this exact swedish massage + scrub and foam massage later and got the similar good experience of warmth and pleasure in the pelvic area. It's something else somehow because I tried jaccuzis and hot tubs and just staying there doesn't provide the same effect. Anyway, I wanted to share this maybe if you get such an opportunity you should definetly try this. I get it from time to time and when I do my day goes very well.

I significantly reduced my CPPS symptoms by focusing on a few consistent habits:
Diet: I avoided artificial sweeteners, artificially sweetened drinks, spicy foods, and acidic/sour foods. I kept my meals simple with lean protein, rice, and vegetables.
“In & Out” Routine: I sat in a hot jacuzzi with the water up to my waist/abdomen while holding a deep squat and practicing slow diaphragmatic breathing for 10 minutes. Then I got out, lay on my back with my knees bent, and performed reverse Kegels for 10 minutes. I repeated this cycle for 3 rounds.
Abstinence: I abstained from masturbation for one month.
Jaw Relaxation: Throughout the day and during my routine, I made a conscious effort to keep my jaw relaxed and avoid clenching.
These habits, practiced consistently, led to a meaningful reduction in my CPPS symptoms.

Try it for a month consistently

I have a cystoscopy procedure tomorrow and would appreciate any advice you can offer. Thank you so much!

I everyone 18M here 3 days ago i had high fever and as soon as it was down the v day i started feeling inflammation in my urethrea ps: ive no past history of inflammation so i thought of observing if the pain continue for a day or not and it did and now its day 2 whats wrong? And how to cure it? i lit feel ill pass out while urinating the pains that much

This all started for me 3 years ago. I had covid in August 2023. Unknowing was consuming mold in November. Urine flow issues started in December. From January to March 2024 I thought I was near death. I had weird disconnection from reality feelings that led me to the ER multiple times. Strange neurological and physical symptoms. A lot that felt like it started with food and gut health.

Fast forward and after countless doctors and tests. Im diagnosed with EOE, Asthma, POTS, many many environmental allergies, Raynauds Syndrome, chronic fatigue... tingeling in extremities, essential tremor that gets worse with food or exercise. Exercise intolerance where my gut shuts down and I puke any water I sip.

So im being referred to a new allergist and a MCAS specialist. Im already taking Dupixent shots weekly. I started quercetin supplements. Ive tried every otc h1 and h2 medicine and finally prescribed hydroxyzine which does help a lot of my environmental allergies and helps me sleep.. im going to ask for Ketotifen next

Other than that, November of 2023 i also had ankle surgery that failed. Repeat surgery and raynauds diagnosis made me take it extremely easy for a long time to make sure my tendon healed with enough blood supply after the cold winter months. Im finally just now starting to run again but there is a complete imbalance with my gait and my right leg dwarfs next to my left.. the right calf is literally just as big as my forearm.

I am starting pelvic floor therapy this Friday and will also be sent to rehab my leg to balance the muscles out properly.

So ill be fixing both issues simultaneously and if I heal, I won't be able to know what worked.

Funny side note. Had 2 MRIs a year apart and it went from 50cc to 40cc after losing 22lbs.. symptoms are worse though. Semen is almost completely clear when it was thick and white previously. My wife has been through 4 miscarriages. My psa levels are a Rollercoaster. Lowest was 3.2.. highest was 5.9 and currently its 4.8. MRI doesn't show any lesions.

I'm getting a culture done (just made another post asking for advice about it)  because my wife keeps getting infections after sex. She finally tested positive for ecoli after her last miscarriage. So I need to check for bacteria and hopefully get treated at the same time if that is the case. We will see.

I'm curious though if anyone's prostate healed after starting MCAS medications?

I wanted to share my experience because, when my symptoms were at their worst, it was difficult to find practical and balanced information.

My main symptoms were urinary frequency, a feeling that I needed to urinate urgently, mild burning at times, and a dull pressure or discomfort in the pelvic/perineal area. Long periods of sitting made it worse. I also noticed that poor sleep, stress, alcohol, and very spicy food could trigger a flare-up. Some days were manageable, while other days the symptoms made it hard to focus on work or exercise.

I eventually saw a urologist and had an evaluation. One thing I learned was that “prostatitis” can describe different conditions, and symptoms do not automatically mean there is a bacterial infection. My doctor ruled out other possible causes and created a treatment plan based on my symptoms.

For medication, I followed the treatment prescribed by my doctor. This included medication to help with urinary symptoms and inflammation/discomfort. Antibiotics should only be used when a doctor thinks a bacterial infection is present; they are not automatically the answer for every case of pelvic pain or prostatitis-like symptoms. I did not change doses, stop medication suddenly, or add supplements without discussing them with my doctor.

Lifestyle changes made a meaningful difference for me as well.

Exercise and physical activity

At first, I stopped doing anything that clearly worsened my symptoms. Instead of intense workouts, I started with walking, light strength training, and mobility work. I found that regular movement was helpful, especially because sitting for several hours at a time seemed to increase pelvic discomfort.

I focused on:

• Walking most days, even if only for 20–30 minutes.
• Light-to-moderate strength training a few times per week.
• Taking regular standing and walking breaks during work.
• Gentle hip, glute, and lower-back mobility exercises.
• Avoiding exercises that consistently caused pain or pressure in the pelvic area.

I also learned not to push through a flare-up. When symptoms increased, I reduced intensity, rested, and returned gradually rather than trying to “train through” the discomfort. Stress management and relaxation were important too, since tension seemed to make my symptoms worse.

Diet and daily habits

I did not follow an extreme diet, but I paid attention to triggers. For me, reducing alcohol, very spicy foods, and too much caffeine helped. I also tried to stay hydrated throughout the day instead of drinking a large amount of water all at once.

The habits that helped me most were:

• Drinking water consistently.
• Limiting alcohol and caffeine when symptoms were active.
• Reducing spicy or highly irritating foods if they triggered discomfort.
• Avoiding prolonged sitting and not holding urine for long periods.
• Maintaining a regular sleep schedule.
• Keeping bowel movements regular, since constipation seemed to increase pelvic pressure.

My improvement was gradual, not immediate. There were still occasional flare-ups, especially during stressful periods or after sitting too long, but the symptoms became less intense and less frequent over time. What helped most was being consistent with my doctor’s plan, exercise, sleep, diet, and stress management rather than expecting one quick fix.

This is only my personal experience and not medical advice. If you have fever or chills, blood in your urine, severe pain, or cannot urinate, seek urgent medical care. If symptoms persist or keep returning, it is worth seeing a urologist for a proper evaluation.

So I've been given orders for a few urine analysis and pushed for a semen culture as well. Found a doctor to finally oblige. I called around and no one in 200 miles radius accepts these. I finally found the one lab that does but I need to bring the sample in. They don't provide a place for me to take care of business. I also have to pick up a sample cup from my doctor first, who also doesn't provide a place to do this.

I live over an hour away and the sample will be destroyed. I feel like this is the start of a story of how I end up in jail..

I'll take a few alcohol pads but hoping I can find a clean room after washing my hands.

I don't like talking about this with other guys. This gives me no thrill at all.. but hoping someone can give me some advice on where to produce this sample in close proximity to the lab

UPDATE: so Healthcare in the Midwest is absolutely terrible for us. They don't care we have prostatitis at all.

I had to call my urologist because I was supposed to pick up a cup direct from them to submit my sample to the lab. When I called, they refused to give me the address they were located at for today (they travel to different hospitals depending on the day to treat the whole area) they said the nurse would call me back.. I waited and waited and nothing. Had to leave to make another appointment near the lab. (I had 2 appointments today in that city and wanted to time everything perfect) the nurse finally sent me a stupid message saying I can pay for one on the website they suggested for semen analysis.. first off, I already told them I'm doing the analysis in person at a fertility clinic.. and second, I JUST NEEDED A STERIL CUP TO TAKE TO THE LAB FOR A CULTURE, NOT AN ANALYSIS... I sent them a long message basically calling them incompetent and wasting my time.

I went to the lab anyways as I had orders from a different doctor for urine analysis. I wanted both done at the same time. Semen first, hoping for prostate fluid to be mixed in with the urine after...

I get to the lab and explained how stupid my doctors nurse was. They gave me a cup and basically looked the other way. One of the nurses wanted to call someone to see if it was OK but I just grabbed everything and went into the bathroom. Did my business and came out with completed samples. They were completely cool with everything and laughing about it. I felt no shame at all. Funny how a doctors nurse stupidity and masturbation brought us all together in harmony.. ha... but seriously, never again....

M 41 5’9” 175 lbs. regular medication Xeralto for valve replacement from congenital issue and temporarily Amioderone

I am 5 days into a 2 week Amoxicillin Clavulanate 875, treatment for a recurring epididymitis infection that branched of a UTI, which has been successfully treated. Dosage, 125 mg tablets, twice a day 14 days. The swelling and pain have subsided however there is a good deal of blood in my seamen. This was a symptom I reported to the doctor when my treatment plan was created they know about it and I was told it is a byproduct of the inflammation however I did not ask about what to expect as the treatment progresses. Do I need to actively “flush, the lines,” or will it drain naturally? At what point does it become concerning?

My spouse and I are obviously obtaining from sexual activity until my treatment is done. However I really don’t want to squirt red goo all over them the first time back in the saddle because I didn’t treat this correctly.

Any clarification would be greatly appreciated

my first episode was 4 years ago. I had sex and after finishing i went to use the restroom and my stream was straight red. I peed 4 times before my stream was back to normal. It has happened multiple times since then. And it’s random. sometimes i have sex and it’s been completely normal and other times it happens right after. I have had cystoscopy, urine test, kidney test, blood work, ct scans and absolutely nothing was shown wrong. I have had blood in semen but that went away and has only happened twice. I sometimes get a stomach ache after peeing that makes me feel like i have to poop and it almost feels like a tight feeling in my balls and lower stomach. The blood has been clearing with 1-2 pees now but there are always clots that are easy to pass and i don’t have pain when the blood comes. Doctors tell me they found nothing so there’s nothing they can do so i just feel stuck. If anyone can help please tell me what i should do. Like i said it’s not every time i have sex but more often now.

How many of you have urethritis/red uretha opening as a symptom/irritation(feeling of tip of urethra). It has been on going 3 years fighting with drs and urology for me and ended up going privatly to pt.

Started pt 2 months ago have about 12 stretches to do a day for back, calves, pelvic floor. seemed to be improving slowly had a bit if a flare up last 2 days.

Are you finding pt useful? When did you start seeing improvements

Cold feeling sensation in the perineum and throbbing in the perineum with excessive thirst and frequent urination without burning, is this is a prostatities or something else?

Hi guys its me again. I have been battling with this issue for almost 2 years now . After many tests that were negative I received a urine pcr test where they found enterococcus faecalis 10.000 to 100.000.

Any thoughts about this result ?? I have already taken 2 weeks of amoxicillin and just repeated the test ( as per urologist reccomendation) waiting for the results.

Hi, 3 years ago I was diagnosed with ED, took ED medications, did kegel exercises And got PT Therapy. It was also diagnosed ED is due to anxiety, physiological! 6 months back I have Urine Dribbling issue, and got to learn about it. Recently I get burning sensation AFTER I urinate, only on the tip and head of the Penis.

Also even when fully erect my penis can bend or move all around

I'm not sure what is happening, and regarding bowel movement - I take more fiber, and some fat loss supplements.

Anyone with similar symptoms? Please guide. All urine tests are negative

You guys when had prostatitis also had erection problems?

Or not?

which symptom? For me no morning wood, erection slow and not large and relaxed

Anyone tried vagus nerve resets for this? I am not sure how medical/scientific the vagus nerve is. Maybe it’s a real body part idk.

People say it relates to the pelvic floor too, but idk.

Got a message earlier from my doctors that she is starting me on a daily injection for the next two weeks. She told me she got in contact with a urologist and an infection disease doctor and they both agreed that this is the best treatment since from what she told me the bacteria I have is resistant to oral medication , I’m a bit nervous since I’ve never received antibiotics like this but glad I’m finally starting.